PL436113A1 - Membrane made of organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof - Google Patents

Membrane made of organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof

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Publication number
PL436113A1
PL436113A1 PL436113A PL43611320A PL436113A1 PL 436113 A1 PL436113 A1 PL 436113A1 PL 436113 A PL436113 A PL 436113A PL 43611320 A PL43611320 A PL 43611320A PL 436113 A1 PL436113 A1 PL 436113A1
Authority
PL
Poland
Prior art keywords
membrane
temperature
calenders
carried out
transition temperature
Prior art date
Application number
PL436113A
Other languages
Polish (pl)
Other versions
PL240235B1 (en
Inventor
Andrzej Swinarew
Jadwiga Gabor
Hubert Okła
Szymon Skoczyński
Ewa Trejnowska
Barbara Szpikowska-Sroka
Magdalena Popczyk
Arkadiusz Stanula
Original Assignee
Uniwersytet Śląski W Katowicach
Akademia Wychowania Fizycznego Im. Jerzego Kukuczki W Katowicach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Uniwersytet Śląski W Katowicach, Akademia Wychowania Fizycznego Im. Jerzego Kukuczki W Katowicach filed Critical Uniwersytet Śląski W Katowicach
Priority to PL436113A priority Critical patent/PL240235B1/en
Publication of PL436113A1 publication Critical patent/PL436113A1/en
Priority to PCT/IB2021/061016 priority patent/WO2022113019A1/en
Publication of PL240235B1 publication Critical patent/PL240235B1/en

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  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)

Abstract

Przedmiotem wynalazku jest membrana z organicznego materiału o właściwościach porotwórczych, przeciwzapalnych i przeciwkrzepliwych oraz sposób jej otrzymywania polegający na tym, że w pierwszym etapie wytwarza się materiał do budowy membrany, w taki sposób, że do reaktora wprowadza się w atmosferze gazu inertnego rozpuszczalnik polarny oraz kwas wybrany spośród: kwas siarkowy VI, kwas chlorowodorowy lub kwas octowy, w proporcjach od 2 ÷ 0,002 do 7 ÷ 0,002, a następnie na 50 mL tak powstałej mieszaniny dodaje się 4-(difenyloamino)benzaldehyd w ilości od 0,2 g do 0,7 g oraz 1,3-indandion w ilości od 0,01 g do 0,08 g i miesza do uzyskania jednorodnej mieszaniny, po czym zawiesinę przemywa się gazem inertnym, podgrzewa doprowadzając do wrzenia pod chłodnicą zwrotną w atmosferze gazu inertnego i miesza intensywnie przy 100 - 1000 obr./min, w czasie co najmniej 18 godzin, po procesie mieszania powstałą mieszaninę chłodzi się do temperatury od 20 do 35°C i poddaje chromatografii kolumnowej w złożu SiO2 i w fazie ruchomej mieszaniny heksanu i chlorku metylenu, następnie suszy się próżniowo w czasie co najmniej 20 godzin do stałej masy, po czym rekrystalizuje się z chloroformu, a rekrystalizat umieszcza się w homogenizatorze i wprowadza bazę w postaci: polipropylenu (PP) lub poliuretanu (PU) lub politereftalanu etylenu (PET) lub poliwęglanu (PC) lub polioksymetylenu (POM) lub polisulfonu (PSU) lub silikonu lub polimeru fluorowego, korzystnie poli(tetrafluoroetylenu) (PTFE) lub polifluorku winylidenu (PVDF) lub kopolimeru tetrafluoroetylenu i heksafluoropropylenu (FEP), w proporcji baza-rekrystalizat od 50 ÷ 2 do 5000 ÷ 2, a następnie miesza aż do uzyskania jednorodnej mieszaniny i suszy przez czas co najmniej 20 godzin w temperaturze 80 - 110°C, po czym materiał wytłacza się na głowicy liniowej w postaci struny lub na głowicy krzyżowej w postaci rurki lub na głowicy płaskiej w postaci folii, a w kolejnym etapie przeprowadza się proces immobilizacji albuminy do struktury sterycznej tak otrzymanego materiału w sposób zapewniający jej zawartość w materiale w proporcji baza - albumina od 80 ÷ 1 do 1200 ÷ 1, w taki sposób, że po wstępnym ochłodzeniu w łaźni zawierającej przesycony wodny roztwór albuminy do temperatury ±30°C od temperatury przejścia plastycznego, dokonuje się jego rozciągnięcia na kalandrach, następnie przeprowadza się drugi, finalny etap wytwarzania membrany, który realizuje się w trojaki sposób zależny od formy materiału otrzymanego w etapie pierwszym, to jest albo: - według wariantu a), w którym materiał otrzymany w pierwszym etapie w formie struny doprowadza się do temperatury ±30°C od temperatury przejścia plastycznego, po czym dokonuje się jej rozciągnięcia na kalandrach, tak aby otrzymać membranę w postaci płaskiej folii o grubości od 0,2 do 200 μm, albo - według wariantu b), w którym materiał otrzymany w pierwszym etapie w formie rurki doprowadza się do temperatury ±30°C od temperatury przejścia plastycznego, po czym dokonuje się jej rozciągnięcia na kalandrach, tak aby otrzymać membranę w postaci rurki o średnicy zewnętrznej od 30 do 600 μm, albo - według wariantu c), w którym materiał otrzymany w pierwszym etapie w formie folii doprowadza się do temperatury ±30°C od temperatury przejścia plastycznego, po czym dokonuje się jej rozciągnięcia na kalandrach, tak aby otrzymać membranę w postaci płaskiej folii o grubości od 0,2 do 200 μm.The subject of the invention is a membrane made of an organic material with pore-forming, anti-inflammatory and anticoagulant properties and a method of its preparation consisting in the first stage of producing a material for the construction of the membrane in such a way that a polar solvent and an acid are introduced into the reactor under an atmosphere of inert gas. selected from: sulfuric acid VI, hydrochloric acid or acetic acid, in proportions from 2 ÷ 0.002 to 7 ÷ 0.002, and then 4- (diphenylamino) benzaldehyde in the amount from 0.2 g to 0 is added to 50 mL of the mixture thus formed, 7 g and 1,3-indandion in an amount from 0.01 g to 0.08 g and stirred until a homogeneous mixture was obtained, then the suspension was washed with inert gas, heated to reflux under an inert gas atmosphere and stirred intensively at 100 - 1000 rpm for at least 18 hours, after the stirring process, the resulting mixture was cooled to 20 to 35 ° C and subjected to column chromatography in SiO2 bed and in the mobile phase of a mixture of hexane and methylene chloride, then vacuum dried for at least 20 hours to a constant mass, then recrystallized from chloroform, and the recrystallization product is placed in a homogenizer and the base is introduced in the form of: polypropylene (PP) or polyurethane (PU) or polyethylene terephthalate (PET) or polycarbonate (PC) or polyoxymethylene (POM) or polysulfone (PSU) or silicone or a fluoropolymer, preferably poly (tetrafluoroethylene) (PTFE) or polyvinylidene fluoride (PVDF) or a copolymer of tetrafluoroethylene and hexafluoroethylene FEP), in the base-recrystallization ratio from 50 ÷ 2 to 5000 ÷ 2, then mixed until a homogeneous mixture is obtained and dried for at least 20 hours at the temperature of 80 - 110 ° C, after which the material is extruded on a linear head at in the form of a string or on a cross head in the form of a tube or on a flat head in the form of a foil, and in the next stage the process of albumin immobilization to the rudder structure is carried out of the material thus obtained in a way that ensures its content in the material in the proportion base - albumin from 80 ÷ 1 to 1200 ÷ 1, in such a way that after initial cooling in a bath containing a supersaturated aqueous albumin solution to a temperature of ± 30 ° C from the plastic transition temperature , it is stretched on calenders, then the second, final step of membrane production is carried out, which is carried out in three ways depending on the form of the material obtained in the first step, that is either: - according to variant a), in which the material obtained in the first step in the form of a string, it is brought to a temperature of ± 30 ° C from the plastic transition temperature, and then it is stretched on calenders so as to obtain a membrane in the form of a flat foil with a thickness of 0.2 to 200 μm, or - according to variant b), in which the material obtained in the first stage in the form of a tube is brought to a temperature of ± 30 ° C from the plastic transition temperature, after which it is carried out pulls on calenders so as to obtain a membrane in the form of a tube with an external diameter of 30 to 600 μm, or - according to variant c), in which the material obtained in the first stage in the form of a film is brought to a temperature of ± 30 ° C from the plastic transition temperature, then it is stretched on calenders so as to obtain a membrane in the form of a flat foil with a thickness of 0.2 to 200 μm.

PL436113A 2020-11-27 2020-11-27 Membrane made of organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof PL240235B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PL436113A PL240235B1 (en) 2020-11-27 2020-11-27 Membrane made of organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof
PCT/IB2021/061016 WO2022113019A1 (en) 2020-11-27 2021-11-26 A membrane made of organic material with pore-forming, anti-inflammatory and anticoagulant properties and the method of obtaining it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL436113A PL240235B1 (en) 2020-11-27 2020-11-27 Membrane made of organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof

Publications (2)

Publication Number Publication Date
PL436113A1 true PL436113A1 (en) 2021-07-05
PL240235B1 PL240235B1 (en) 2022-03-07

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PL436113A PL240235B1 (en) 2020-11-27 2020-11-27 Membrane made of organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof

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PL240235B1 (en) 2022-03-07

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