PL436104A1 - Organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof - Google Patents
Organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereofInfo
- Publication number
- PL436104A1 PL436104A1 PL436104A PL43610420A PL436104A1 PL 436104 A1 PL436104 A1 PL 436104A1 PL 436104 A PL436104 A PL 436104A PL 43610420 A PL43610420 A PL 43610420A PL 436104 A1 PL436104 A1 PL 436104A1
- Authority
- PL
- Poland
- Prior art keywords
- mixture
- bivaluridine
- temperature
- inert gas
- hours
- Prior art date
Links
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
Przedmiotem zgłoszenia jest organiczny materiał o właściwościach porotwórczych, przeciwzapalnych i przeciwkrzepliwych oraz sposób jego otrzymywania polegający na tym, że do reaktora wprowadza się w atmosferze gazu inertnego rozpuszczalnik polarny oraz kwas wybrany spośród: kwas siarkowy VI, kwas chlorowodorowy lub kwas octowy, w proporcjach od 2 ÷ 0,002 do 7 ÷ 0,002, a następnie na 50 mL tak powstałej mieszaniny dodaje się 4-(difenyloamino)benzaldehyd w ilości od 0,2 g do 0,7 g oraz 1,3-indandion w ilości od 0,01 g do 0,08 g i miesza do uzyskania jednorodnej mieszaniny, po czym zawiesinę przemywa się gazem inertnym przez czas co najmniej 5 minut, podgrzewa doprowadzając do wrzenia pod chłodnicą zwrotną w atmosferze gazu inertnego i miesza intensywnie przy 100 - 1000 obr./min, w czasie co najmniej 18 godzin. Po procesie mieszania powstałą mieszaninę chłodzi się do temperatury od 20 do 35°C i poddaje chromatografii kolumnowej w złożu SiO2 i w fazie ruchomej mieszaniny heksanu i chlorku metylenu, w ilości heksanu od 0,5 do 2-krotności objętości mieszaniny, a chlorku metylenu od 0,5 do 2-krotności objętości mieszaniny reakcyjnej. Następnie suszy się próżniowo w czasie co najmniej 20 godzin do stałej masy, po czym rekrystalizuje się z chloroformu. Produkt po rekrystalizacji z chloroformu (rekrystalizat) umieszcza się w homogenizatorze i wprowadza bazę w postaci: polipropylenu (PP) lub poliuretanu (PU) lub poli(tereftalanu etylenu) (PET) lub poliwęglanu (PC) lub polioksymetylenu (POM) lub polisulfonu (PSU) lub silikonu lub polimeru fluorowego, korzystnie poli(tetrafluoroetylenu) (PTFE) lub polifluorku winylidenu (PVDF) lub kopolimeru tetrafluoroetylenu i heksafluoropropylenu (FEP), w proporcji bazarekrystalizat od 50 ÷ 2 do 5000 ÷ 2, a następnie miesza aż do uzyskania jednorodnej mieszaniny i suszy przez czas co najmniej 20 godzin w temperaturze 80 — 110°C, po czym materiał wytłacza się na głowicy liniowej w postaci struny, lub na głowicy krzyżowej w postaci rurki, lub na głowicy płaskiej w postaci folii, a w kolejnym etapie przeprowadza się proces immobilizacji biwalurydyny do struktury sterycznej tak otrzymanego materiału w sposób zapewniający jej zawartość w materiale w proporcji baza-biwalurydyna od 80 ÷ 1 do 1200 ÷ 1, w taki sposób, że po wstępnym ochłodzeniu w łaźni zawierającej przesycony wodny roztwór biwalurydyny do temperatury ±30°C od temperatury przejścia plastycznego, dokonuje się jego rozciągnięcia na kalandrach, tak aby otrzymać wydłużenie 5 ÷ 20-krotne, co skutkuje powstaniem mikroporów, w których immobilizuje się biwalurydyna.The subject of the application is an organic material with pore-forming, anti-inflammatory and anticoagulant properties and a method of its preparation consisting in introducing a polar solvent under an inert gas atmosphere and an acid selected from: sulfuric acid VI, hydrochloric acid or acetic acid, in proportions from 2 ÷ 0.002 to 7 ÷ 0.002, and then, 4- (diphenylamino) benzaldehyde in the amount from 0.2 g to 0.7 g and 1,3-indandione in the amount from 0.01 g to 0 are added to 50 mL of the mixture thus formed. , 08 g and stirred until a homogeneous mixture is obtained, then the suspension is flushed with inert gas for at least 5 minutes, heated to reflux under an inert gas atmosphere, and stirred intensively at 100 - 1000 rpm for at least 18 hours. After the mixing process, the resulting mixture is cooled to a temperature of 20 to 35 ° C and subjected to column chromatography in the SiO2 bed and in the mobile phase of a mixture of hexane and methylene chloride, in the amount of hexane from 0.5 to 2 times the volume of the mixture, and methylene chloride from 0 , 5 to 2 times the volume of the reaction mixture. It is then dried under vacuum for at least 20 hours to constant weight and then recrystallized from chloroform. The product after recrystallization from chloroform (recrystallization) is placed in a homogenizer and the base is in the form of: polypropylene (PP) or polyurethane (PU) or poly (ethylene terephthalate) (PET) or polycarbonate (PC) or polyoxymethylene (POM) or polysulfone (PSU) ) or silicone or fluoropolymer, preferably poly (tetrafluoroethylene) (PTFE) or polyvinylidene fluoride (PVDF) or a copolymer of tetrafluoroethylene and hexafluoropropylene (FEP), in the proportion of basarecrystalline from 50-2 to 5000-2, and then mixed until a homogeneous mixture is obtained and dried for at least 20 hours at a temperature of 80 - 110 ° C, after which the material is extruded on a linear head in the form of a string, or on a cross head in the form of a tube, or on a flat head in the form of a foil, and then the process is carried out immobilization of bivaluridine to the steric structure of the material thus obtained in such a way as to ensure its content in the material in the base-bivaluridine ratio from 80 ÷ 1 to 1200 ÷ 1, such the way that after initial cooling in a bath containing a supersaturated aqueous solution of bivaluridine to a temperature of ± 30 ° C from the plastic transition temperature, it is stretched on calenders so as to obtain an elongation of 5-20 times, which results in the formation of micropores in which it is immobilized bivaluridine.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL436104A PL243070B1 (en) | 2020-11-27 | 2020-11-27 | Organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof |
PCT/IB2021/061010 WO2022113015A1 (en) | 2020-11-27 | 2021-11-26 | Organic material with pore-forming, anti-inflammatory and anticoagulant properties and the method of its preparation |
EP21897295.8A EP4251695A1 (en) | 2020-11-27 | 2021-11-26 | Organic material with pore-forming, anti-inflammatory and anticoagulant properties and the method of its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL436104A PL243070B1 (en) | 2020-11-27 | 2020-11-27 | Organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
PL436104A1 true PL436104A1 (en) | 2021-07-05 |
PL243070B1 PL243070B1 (en) | 2023-06-12 |
Family
ID=76689695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL436104A PL243070B1 (en) | 2020-11-27 | 2020-11-27 | Organic material with pore-forming, anti-inflammatory and anticoagulant properties and method of preparation thereof |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL243070B1 (en) |
-
2020
- 2020-11-27 PL PL436104A patent/PL243070B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL243070B1 (en) | 2023-06-12 |
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