PL434504A1 - Biosensor do oznaczania interleukiny 6 (IL-6) techniką powierzchniowego rezonansu plazmonów w wersji Imaging - Google Patents
Biosensor do oznaczania interleukiny 6 (IL-6) techniką powierzchniowego rezonansu plazmonów w wersji ImagingInfo
- Publication number
- PL434504A1 PL434504A1 PL434504A PL43450420A PL434504A1 PL 434504 A1 PL434504 A1 PL 434504A1 PL 434504 A PL434504 A PL 434504A PL 43450420 A PL43450420 A PL 43450420A PL 434504 A1 PL434504 A1 PL 434504A1
- Authority
- PL
- Poland
- Prior art keywords
- biosensor
- surface plasmon
- plasmon resonance
- interleukin
- determination
- Prior art date
Links
- 102000004889 Interleukin-6 Human genes 0.000 title abstract 3
- 108090001005 Interleukin-6 Proteins 0.000 title abstract 3
- 229940100601 interleukin-6 Drugs 0.000 title abstract 3
- 238000003384 imaging method Methods 0.000 title abstract 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 title abstract 2
- 239000011521 glass Substances 0.000 abstract 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract 2
- 239000010931 gold Substances 0.000 abstract 2
- 229910052737 gold Inorganic materials 0.000 abstract 2
- QJAOYSPHSNGHNC-UHFFFAOYSA-N octadecane-1-thiol Chemical compound CCCCCCCCCCCCCCCCCCS QJAOYSPHSNGHNC-UHFFFAOYSA-N 0.000 abstract 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 abstract 1
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 abstract 1
- 229940124790 IL-6 inhibitor Drugs 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 229910052804 chromium Inorganic materials 0.000 abstract 1
- 239000011651 chromium Substances 0.000 abstract 1
- 229940116886 human interleukin-6 Drugs 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Przedmiotem wynalazku jest biosensor do specyficznego oznaczania stężenia ludzkiego interleukiny 6 (IL-6) w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging, który zawiera płytkę szklaną pokrytą warstwą złota oraz siatkę polimeru tworzącą pęk miejsc aktywnych zawierających warstwę receptorową, którą stanowi galiellakton jako inhibitor IL-6 (5) połączony poprzez oddziaływania hydrofobowe z linkerem (4), w postaci 1-oktadekanotiolu, łączącym receptor z warstwą złota (3) na podłożu z chromu (2) pokrywającą płytkę szklaną (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL434504A PL241900B1 (pl) | 2020-06-30 | 2020-06-30 | Biosensor do oznaczania interleukiny 6 (IL-6) techniką powierzchniowego rezonansu plazmonów w wersji Imaging |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL434504A PL241900B1 (pl) | 2020-06-30 | 2020-06-30 | Biosensor do oznaczania interleukiny 6 (IL-6) techniką powierzchniowego rezonansu plazmonów w wersji Imaging |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL434504A1 true PL434504A1 (pl) | 2022-01-03 |
| PL241900B1 PL241900B1 (pl) | 2022-12-19 |
Family
ID=80001127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL434504A PL241900B1 (pl) | 2020-06-30 | 2020-06-30 | Biosensor do oznaczania interleukiny 6 (IL-6) techniką powierzchniowego rezonansu plazmonów w wersji Imaging |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL241900B1 (pl) |
-
2020
- 2020-06-30 PL PL434504A patent/PL241900B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL241900B1 (pl) | 2022-12-19 |
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