PL439848A1 - Biosensor do specyficznego oznaczania stężenia receptora VEGF-R2 w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging - Google Patents

Biosensor do specyficznego oznaczania stężenia receptora VEGF-R2 w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging

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Publication number
PL439848A1
PL439848A1 PL439848A PL43984821A PL439848A1 PL 439848 A1 PL439848 A1 PL 439848A1 PL 439848 A PL439848 A PL 439848A PL 43984821 A PL43984821 A PL 43984821A PL 439848 A1 PL439848 A1 PL 439848A1
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Poland
Prior art keywords
vegf
biosensor
receptor
surface plasmon
body fluids
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PL439848A
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English (en)
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PL249084B1 (pl
Inventor
Ewa Gorodkiewicz
Łukasz Ołdak
Bogdan Wyrwas
Zenon Łukaszewski
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Politechnika Poznańska
Uniwersytet W Białymstoku
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Priority to PL439848A priority Critical patent/PL249084B1/pl
Publication of PL439848A1 publication Critical patent/PL439848A1/pl
Publication of PL249084B1 publication Critical patent/PL249084B1/pl

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G01N21/553—Attenuated total reflection and using surface plasmons
    • G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Przedmiotem zgłoszenia jest Biosensor do specyficznego oznaczania stężenia receptora VEGF-R2 w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging, który zawiera płytkę szklaną (1) pokrytą warstwą złota (3) oraz siatkę (4) polimeru, tworzącą pęk miejsc aktywnych zawierających warstwę receptorową, w której warstwę receptorową stanowi monoklonalne królicze przeciwciało specyficzne na VEGF-R2 (6) połączone kowalencyjnie z linkerem (5), w postaci cysteaminy, łączącym receptor z warstwą złota (3), na podłożu z tytanu (2), pokrywającą płytkę szklaną (1).
PL439848A 2021-12-15 2021-12-15 Biosensor do specyficznego oznaczania stężenia receptora VEGF-R2 w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging PL249084B1 (pl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL439848A PL249084B1 (pl) 2021-12-15 2021-12-15 Biosensor do specyficznego oznaczania stężenia receptora VEGF-R2 w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL439848A PL249084B1 (pl) 2021-12-15 2021-12-15 Biosensor do specyficznego oznaczania stężenia receptora VEGF-R2 w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging

Publications (2)

Publication Number Publication Date
PL439848A1 true PL439848A1 (pl) 2023-06-19
PL249084B1 PL249084B1 (pl) 2026-02-23

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PL439848A PL249084B1 (pl) 2021-12-15 2021-12-15 Biosensor do specyficznego oznaczania stężenia receptora VEGF-R2 w płynach ustrojowych i homogenatach tkankowych techniką powierzchniowego rezonansu plazmonów w wersji Imaging

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PL249084B1 (pl) 2026-02-23

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