PL426027A1 - 3β-Hydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β-hydroxy-5α-chloro-6,19-oxidoandrostan-17-one - Google Patents

3β-Hydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β-hydroxy-5α-chloro-6,19-oxidoandrostan-17-one

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Publication number
PL426027A1
PL426027A1 PL426027A PL42602718A PL426027A1 PL 426027 A1 PL426027 A1 PL 426027A1 PL 426027 A PL426027 A PL 426027A PL 42602718 A PL42602718 A PL 42602718A PL 426027 A1 PL426027 A1 PL 426027A1
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PL
Poland
Prior art keywords
oxidoandrostan
chloro
hydroxy
preparation
kch
Prior art date
Application number
PL426027A
Other languages
Polish (pl)
Other versions
PL237711B1 (en
Inventor
Ewa Kozłowska
Agata Matera
Edyta Kostrzewa-Susłow
Tomasz Janeczko
Original Assignee
Uniwersytet Przyrodniczy we Wrocławiu
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Publication date
Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL426027A priority Critical patent/PL237711B1/en
Publication of PL426027A1 publication Critical patent/PL426027A1/en
Publication of PL237711B1 publication Critical patent/PL237711B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Przedmiotem zgłoszenia jest 3β-Hydroksy-5α-chloro-6,19-oksidoandrostan-17-onu i sposób wytwarzania 3β-hydroksy-5α-chloro-6,19-oksidoandrostan-17-onu o wzorze 2. Zgodnie z rozwiązaniem, w wyniku działania układu enzymatycznego zawartego w komórkach szczepu Trichoderma atroviride KCh TRW, następuje hydroliza grupy acetylowej przy C-3. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (chloroform).The subject of the application is 3β-Hydroxy-5α-chloro-6,19-oxidoandrostan-17-one and a method for producing 3β-hydroxy-5α-chloro-6,19-oxidoandrostan-17-one of formula 2. According to the solution, as a result operation of the enzymatic system contained in the cells of the Trichoderma atroviride KCh TRW strain, the hydrolysis of the acetyl group at C-3 occurs. The product obtained in this way is isolated from the aqueous culture of the microorganism in a known method, by extraction with an organic solvent immiscible with water (chloroform).

PL426027A 2018-06-22 2018-06-22 3β-Hydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β-hydroxy-5α-chloro-6,19-oxidoandrostan-17-one PL237711B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL426027A PL237711B1 (en) 2018-06-22 2018-06-22 3β-Hydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β-hydroxy-5α-chloro-6,19-oxidoandrostan-17-one

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL426027A PL237711B1 (en) 2018-06-22 2018-06-22 3β-Hydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β-hydroxy-5α-chloro-6,19-oxidoandrostan-17-one

Publications (2)

Publication Number Publication Date
PL426027A1 true PL426027A1 (en) 2020-01-02
PL237711B1 PL237711B1 (en) 2021-05-17

Family

ID=69160760

Family Applications (1)

Application Number Title Priority Date Filing Date
PL426027A PL237711B1 (en) 2018-06-22 2018-06-22 3β-Hydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β-hydroxy-5α-chloro-6,19-oxidoandrostan-17-one

Country Status (1)

Country Link
PL (1) PL237711B1 (en)

Also Published As

Publication number Publication date
PL237711B1 (en) 2021-05-17

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