PL426024A1 - 3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one - Google Patents
3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-oneInfo
- Publication number
- PL426024A1 PL426024A1 PL426024A PL42602418A PL426024A1 PL 426024 A1 PL426024 A1 PL 426024A1 PL 426024 A PL426024 A PL 426024A PL 42602418 A PL42602418 A PL 42602418A PL 426024 A1 PL426024 A1 PL 426024A1
- Authority
- PL
- Poland
- Prior art keywords
- dihydroxy
- chloro
- oxidoandrostan
- preparation
- oxidoandrostane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
- C12P33/08—Hydroxylating at 11 position
- C12P33/10—Hydroxylating at 11 position at 11 alpha-position
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Zgłoszenie dotyczy związku o nazwie 3β,11α-dihydroksy-5α-chloro-6,19-oksidoandrostan-17-onu o wzorze 2 i sposób jego wytwarzania. Powyższy sposób polega na tym, że wyniku działania układu enzymatycznego zawartego w komórkach szczepu Isaria farinosa KCh KW1.1, następuje hydroliza grupy acetylowej przy C-3 i regioselektywna hydroksylacja w pozycji 11α substratu. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (chloroform).The application relates to the compound named 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostane-17-one of the formula 2 and the method of its preparation. The above method is based on the fact that as a result of the activity of the enzyme system contained in the cells of the Isaria farinosa KCh KW1.1 strain, the acetyl group at C-3 is hydrolysed and regioselective hydroxylation in the 11α position of the substrate occurs. The product thus obtained is isolated from the aqueous culture of the micro-organism in a known manner by extraction with a water-immiscible organic solvent (chloroform).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL426024A PL237134B1 (en) | 2018-06-22 | 2018-06-22 | 3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL426024A PL237134B1 (en) | 2018-06-22 | 2018-06-22 | 3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one |
Publications (2)
Publication Number | Publication Date |
---|---|
PL426024A1 true PL426024A1 (en) | 2020-01-02 |
PL237134B1 PL237134B1 (en) | 2021-03-22 |
Family
ID=69160758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL426024A PL237134B1 (en) | 2018-06-22 | 2018-06-22 | 3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one |
Country Status (1)
Country | Link |
---|---|
PL (1) | PL237134B1 (en) |
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2018
- 2018-06-22 PL PL426024A patent/PL237134B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL237134B1 (en) | 2021-03-22 |
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