PL426024A1 - 3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one - Google Patents

3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one

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Publication number
PL426024A1
PL426024A1 PL426024A PL42602418A PL426024A1 PL 426024 A1 PL426024 A1 PL 426024A1 PL 426024 A PL426024 A PL 426024A PL 42602418 A PL42602418 A PL 42602418A PL 426024 A1 PL426024 A1 PL 426024A1
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PL
Poland
Prior art keywords
dihydroxy
chloro
oxidoandrostan
preparation
oxidoandrostane
Prior art date
Application number
PL426024A
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Polish (pl)
Other versions
PL237134B1 (en
Inventor
Ewa Kozłowska
Jordan Sycz
Patryk Kownacki
Edyta Kostrzewa-Susłow
Tomasz Janeczko
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Uniwersytet Przyrodniczy we Wrocławiu
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Application filed by Uniwersytet Przyrodniczy we Wrocławiu filed Critical Uniwersytet Przyrodniczy we Wrocławiu
Priority to PL426024A priority Critical patent/PL237134B1/en
Publication of PL426024A1 publication Critical patent/PL426024A1/en
Publication of PL237134B1 publication Critical patent/PL237134B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Zgłoszenie dotyczy związku o nazwie 3β,11α-dihydroksy-5α-chloro-6,19-oksidoandrostan-17-onu o wzorze 2 i sposób jego wytwarzania. Powyższy sposób polega na tym, że wyniku działania układu enzymatycznego zawartego w komórkach szczepu Isaria farinosa KCh KW1.1, następuje hydroliza grupy acetylowej przy C-3 i regioselektywna hydroksylacja w pozycji 11α substratu. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (chloroform).The application relates to the compound named 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostane-17-one of the formula 2 and the method of its preparation. The above method is based on the fact that as a result of the activity of the enzyme system contained in the cells of the Isaria farinosa KCh KW1.1 strain, the acetyl group at C-3 is hydrolysed and regioselective hydroxylation in the 11α position of the substrate occurs. The product thus obtained is isolated from the aqueous culture of the micro-organism in a known manner by extraction with a water-immiscible organic solvent (chloroform).

PL426024A 2018-06-22 2018-06-22 3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one PL237134B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL426024A PL237134B1 (en) 2018-06-22 2018-06-22 3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL426024A PL237134B1 (en) 2018-06-22 2018-06-22 3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one

Publications (2)

Publication Number Publication Date
PL426024A1 true PL426024A1 (en) 2020-01-02
PL237134B1 PL237134B1 (en) 2021-03-22

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PL426024A PL237134B1 (en) 2018-06-22 2018-06-22 3β,11α-Dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one and method of preparation of 3β,11α-dihydroxy-5α-chloro-6,19-oxidoandrostan-17-one

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Also Published As

Publication number Publication date
PL237134B1 (en) 2021-03-22

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