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Application filed by Uniwersytet Przyrodniczy we WrocławiufiledCriticalUniwersytet Przyrodniczy we Wrocławiu
Priority to PL417198ApriorityCriticalpatent/PL232297B1/en
Publication of PL417198A1publicationCriticalpatent/PL417198A1/en
Publication of PL232297B1publicationCriticalpatent/PL232297B1/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Steroid Compounds
(AREA)
Abstract
Zgłoszenie dotyczy sposobu wytwarzania 3ß,11?-dihydroksyandrost-5-en-7,17-dionu o wzorze 2. W wyniku działania układu enzymatycznego zawartego w komórkach szczepu Beauveria caledonica KCh J3.4 o sekwencji 1, następuje hydroksylacja przy atomie węgla C-7, utlenienie grupy hydroksylowej usytuowanej przy tym węglu do grupy karbonylowej oraz stereoselektywna hydroksylacja przy atomie węgla C-11. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (chloroform).The application relates to a method for producing 3ß, 11'-dihydroxyandrost-5-ene-7,17-dione of formula 2. As a result of the enzyme system contained in the cells of the strain Beauveria caledonica KCh J3.4 with sequence 1, hydroxylation at the carbon C- 7, oxidation of the hydroxyl group located at this carbon to the carbonyl group and stereoselective hydroxylation at the C-11 carbon atom. The product thus obtained is separated from the aqueous culture of the microorganism in a known manner by extraction with a water-immiscible organic solvent (chloroform).
PL417198A2016-05-132016-05-133β, 11α-dihydroxyandrost-5-en-7,17-dione and method for producing new 3β, 11α-dihydroxyandrost-5-en-7,17-dione
PL232297B1
(en)
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