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Priority to PL420187ApriorityCriticalpatent/PL235399B1/en
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Publication of PL235399B1publicationCriticalpatent/PL235399B1/en
Preparation Of Compounds By Using Micro-Organisms
(AREA)
Steroid Compounds
(AREA)
Abstract
Zgłoszenie dotyczy sposobu wytwarzania 17a-oxa-D-homo-androst-4-en-17-onu o wzorze 2. W wyniku działania układu enzymatycznego zawartego w komórkach szczepu Penicillium chrysogenum KCh S4, następuje regioselektywna laktonizacja pierścienia D, poprzedzona utlenieniem grupy hydroksylowej przy trzecim atomie węgla i izomeryzacją wiązania podwójnego z 5-en do 4-en. Uzyskany w ten sposób produkt wydziela się z wodnej kultury mikroorganizmu, znanym sposobem, przez ekstrakcję rozpuszczalnikiem organicznym niemieszającym się z wodą (chloroform).The application relates to a method for producing 17a-oxa-D-homo-androst-4-en-17-one of formula 2. As a result of the enzymatic system contained in the cells of the Penicillium chrysogenum KCh S4 strain, there is regioselective lactation of the D ring preceded by oxidation of the hydroxyl group at third carbon atom and isomerization of the double bond from 5-ene to 4-ene. The product thus obtained is separated from the aqueous culture of the microorganism in a known manner by extraction with a water-immiscible organic solvent (chloroform).
PL420187A2017-01-132017-01-13Method for producing 17a-oxa-D-homo-androst-4-en-17-one
PL235399B1
(en)
3β-Hydroxy-5α-chloro-17a-oxa-D-homo-6,19-oxidoandrostan-17-one and method of preparation of 3β-hydroxy-5α-chloro-17a-oxa-D-homo-6,19-oxidoandrostane-17-one
3β-Hydroxy-5α-chloro-17a-oxa-D-homo-6,19-oxidoandrostan-17-one and method of preparation of 3β-hydroxy-5α-chloro-17a-oxa-D-homo-6,19-oxidoandrostane-17-one
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2'-O-β-D-(4"-O-Methylglucopyranosyl)-5'-methoxyflavone and method of preparing 2'-O-β-D-(4"-O-methylglucopyranosyl)-5'-methoxyflavone