PL424555A1 - Sposób oczyszczania i/lub rozdzielania surfaktantów lipopeptydowych pochodzenia naturalnego z wykorzystaniem Chromatografii Przeciwprądowej - Google Patents

Sposób oczyszczania i/lub rozdzielania surfaktantów lipopeptydowych pochodzenia naturalnego z wykorzystaniem Chromatografii Przeciwprądowej

Info

Publication number
PL424555A1
PL424555A1 PL424555A PL42455518A PL424555A1 PL 424555 A1 PL424555 A1 PL 424555A1 PL 424555 A PL424555 A PL 424555A PL 42455518 A PL42455518 A PL 42455518A PL 424555 A1 PL424555 A1 PL 424555A1
Authority
PL
Poland
Prior art keywords
purification
separation
surfactants
range
counter
Prior art date
Application number
PL424555A
Other languages
English (en)
Other versions
PL237299B1 (pl
Inventor
Paweł HODUREK
Paweł JAJOR
Marcin ŁUKASZEWICZ
Original Assignee
Boruta-Zachem Biochemia Spółka Z Ograniczoną Odpowiedzialnością
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boruta-Zachem Biochemia Spółka Z Ograniczoną Odpowiedzialnością filed Critical Boruta-Zachem Biochemia Spółka Z Ograniczoną Odpowiedzialnością
Priority to PL424555A priority Critical patent/PL237299B1/pl
Priority to EP19714780.4A priority patent/EP3749429B1/en
Priority to PCT/IB2019/051017 priority patent/WO2019155411A1/en
Publication of PL424555A1 publication Critical patent/PL424555A1/pl
Publication of PL237299B1 publication Critical patent/PL237299B1/pl

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1892—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns the sorbent material moving as a whole, e.g. continuous annular chromatography, true moving beds or centrifugal chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/42—Flow patterns using counter-current
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/381—Flow patterns centrifugal chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Zgłoszenie dotyczy sposobu oczyszczania i/lub rozdzielania surfaktantów lipopeptydowych pochodzenia naturalnego z wykorzystaniem Chromatografii Przeciwprądowej (ang. Countercurrent Chromatography, CCC) charakteryzującego się tym, że: oczyszczanie odbywa się w systemie dwóch częściowo mieszających się faz rozpuszczalnikowych sporządzonych z rozpuszczalników wybranych z grupy wodnych roztworów buforowych, ciekłych alkoholi alifatycznych i ciekłych węglowodorów alifatycznych, przy czym roztwory buforowe mają stabilizowane pH w granicach od 2 do 10 a stężenia jonów buforujących zawierają się w zakresie od 2 do 800 mM, węglowodory alifatyczne powinny mieć ilości węgli od 5 do 12, przy czym w tych układach rozpuszczalników, surfaktanty, o których mowa, wykazują współczynniki podziału w zakresie 0,1 do 10.
PL424555A 2018-02-09 2018-02-09 Sposób oczyszczania i/lub rozdzielania surfaktyny z wykorzystaniem Chromatografii Przeciwprądowej PL237299B1 (pl)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL424555A PL237299B1 (pl) 2018-02-09 2018-02-09 Sposób oczyszczania i/lub rozdzielania surfaktyny z wykorzystaniem Chromatografii Przeciwprądowej
EP19714780.4A EP3749429B1 (en) 2018-02-09 2019-02-08 Method of purifying and/or separating lipopeptide surfactants of natural origin using countercurrent chromatography
PCT/IB2019/051017 WO2019155411A1 (en) 2018-02-09 2019-02-08 Method of purifying and/or separating lipopeptide surfactants of natural origin using countercurrent chromatography

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL424555A PL237299B1 (pl) 2018-02-09 2018-02-09 Sposób oczyszczania i/lub rozdzielania surfaktyny z wykorzystaniem Chromatografii Przeciwprądowej

Publications (2)

Publication Number Publication Date
PL424555A1 true PL424555A1 (pl) 2019-08-12
PL237299B1 PL237299B1 (pl) 2021-04-06

Family

ID=65995792

Family Applications (1)

Application Number Title Priority Date Filing Date
PL424555A PL237299B1 (pl) 2018-02-09 2018-02-09 Sposób oczyszczania i/lub rozdzielania surfaktyny z wykorzystaniem Chromatografii Przeciwprądowej

Country Status (3)

Country Link
EP (1) EP3749429B1 (pl)
PL (1) PL237299B1 (pl)
WO (1) WO2019155411A1 (pl)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110119071A (ko) * 2010-04-26 2011-11-02 한국과학기술연구원 원심분리 분배 크로마토그래피를 사용하여 해조류에서 푸코잔틴을 분리하는 방법
CN105367615A (zh) * 2014-08-29 2016-03-02 上海医药工业研究院 一种大豆苷的分离纯化方法
WO2017072542A1 (en) * 2015-10-26 2017-05-04 Rotachrom Technológiai Kft. Method for the purification of cyclosporine a

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696412B1 (en) * 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110119071A (ko) * 2010-04-26 2011-11-02 한국과학기술연구원 원심분리 분배 크로마토그래피를 사용하여 해조류에서 푸코잔틴을 분리하는 방법
CN105367615A (zh) * 2014-08-29 2016-03-02 上海医药工业研究院 一种大豆苷的分离纯化方法
WO2017072542A1 (en) * 2015-10-26 2017-05-04 Rotachrom Technológiai Kft. Method for the purification of cyclosporine a

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ŁOMIŃSKA MARTA, BIOSURFAKTANTY LIPOPEPTYDOWE: PRODUKCJA 1-7 WŁAŚCIWOŚCI I ZASTOSOWANIE, 2017 *
PAWEŁ JAJOR, SURFACTIN ANALOGUES PRODUCED BY BACILLUS SUBTILIS 1-7 STRAINS GROWN ON RAPESEED CAKE, 2016 *

Also Published As

Publication number Publication date
EP3749429A1 (en) 2020-12-16
EP3749429B1 (en) 2025-03-12
EP3749429C0 (en) 2025-03-12
WO2019155411A1 (en) 2019-08-15
PL237299B1 (pl) 2021-04-06

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