PL413254A1 - Formulation of nanostructured lipid carriers and method for producing it - Google Patents
Formulation of nanostructured lipid carriers and method for producing itInfo
- Publication number
- PL413254A1 PL413254A1 PL413254A PL41325415A PL413254A1 PL 413254 A1 PL413254 A1 PL 413254A1 PL 413254 A PL413254 A PL 413254A PL 41325415 A PL41325415 A PL 41325415A PL 413254 A1 PL413254 A1 PL 413254A1
- Authority
- PL
- Poland
- Prior art keywords
- lipid
- formulation
- temperature
- weight
- solid
- Prior art date
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- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Przedmiotem zgłoszenia jest formulacja nanostrukturalnych nośników lipidowych, która zawiera: - od 1% wag. do 5% wag. oleju z pestek truskawki pozyskanego przez ekstrakcję pestek nadkrytycznym CO2; - od 5% wag. do 15% wag. modyfikowanego wosku pszczelego; - od 2% wag. do 5% wag. hydrofilowego niejonowego emulgatora z grupy alkilopoliglukozydów; - wodę dejonizowaną w uzupełnieniu do 100% wag. Formulację nanostrukturalnych nośników lipidowych wytwarza się sposobem, który obejmuje następujące etapy: a) podgrzanie fazy olejowej, zawierającej olej z pestek truskawki - ciekły lipid i modyfikowany wosk pszczeli - stały lipid, do temperatury o 5°C - 10°C wyższej od temperatury topnienia stałego lipidu; b) podgrzanie fazy wodnej, to jest mieszaniny emulgatora i wody do temperatury o 5°C - 10°C wyższej od temperatury topnienia stałego lipidu; c) wlanie fazy olejowej do fazy wodnej i zdyspergowanie mieszaniny; d) homogenizowanie uzyskanej w punkcie c) pre - emulsji; e) stopniowe chłodzenie uzyskanej formulacji do temperatury pokojowej. Korzystnie homogenizowanie uzyskanej w punkcie c) pre - emulsji prowadzi się metodą ultrasonifikacji.The subject of the application is the formulation of nanostructured lipid carriers, which contains: - from 1 wt. up to 5 wt. strawberry seed oil obtained by extraction with supercritical CO2; - from 5% by weight up to 15 wt. modified beeswax; - from 2% by weight up to 5 wt. a hydrophilic nonionic emulsifier from the group of alkyl polyglucosides; - deionized water in addition to 100% by weight The formulation of nanostructured lipid carriers is prepared by a method that includes the following steps: a) heating the oil phase containing strawberry seed oil - liquid lipid and modified beeswax - solid lipid, to a temperature 5 ° C - 10 ° C higher than the solid melting temperature lipid; b) heating the aqueous phase, i.e. the mixture of emulsifier and water to a temperature 5 ° C - 10 ° C higher than the melting point of the solid lipid; c) pouring the oil phase into the aqueous phase and dispersing the mixture; d) homogenizing the pre-emulsion obtained in c); e) gradual cooling of the resulting formulation to room temperature. Preferably, the homogenization of the pre-emulsion obtained in c) is carried out by ultrasonication.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL413254A PL232678B1 (en) | 2015-07-24 | 2015-07-24 | Formulation of nanostructured lipid carriers and method for producing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL413254A PL232678B1 (en) | 2015-07-24 | 2015-07-24 | Formulation of nanostructured lipid carriers and method for producing it |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL413254A1 true PL413254A1 (en) | 2017-01-30 |
| PL232678B1 PL232678B1 (en) | 2019-07-31 |
Family
ID=57867775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL413254A PL232678B1 (en) | 2015-07-24 | 2015-07-24 | Formulation of nanostructured lipid carriers and method for producing it |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL232678B1 (en) |
-
2015
- 2015-07-24 PL PL413254A patent/PL232678B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL232678B1 (en) | 2019-07-31 |
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