PL408053A1 - Lipide nanoparticles and method for producing them - Google Patents
Lipide nanoparticles and method for producing themInfo
- Publication number
- PL408053A1 PL408053A1 PL40805314A PL40805314A PL408053A1 PL 408053 A1 PL408053 A1 PL 408053A1 PL 40805314 A PL40805314 A PL 40805314A PL 40805314 A PL40805314 A PL 40805314A PL 408053 A1 PL408053 A1 PL 408053A1
- Authority
- PL
- Poland
- Prior art keywords
- lipid
- lipid nanoparticles
- general formula
- concentration
- carriers
- Prior art date
Links
- 239000002105 nanoparticle Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000002632 lipids Chemical class 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 3
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 239000000969 carrier Substances 0.000 abstract 2
- 239000012071 phase Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002047 solid lipid nanoparticle Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Colloid Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Wynalazek ujawnia lipidowe nanocząstki stabilizowane niejonowymi surfaktantami o wzorze ogólnym 1, przy czym długość prostego nasyconego łańcucha węglowodorowego R wynosi od 9 do 15 atomów węgla, znajdującymi zastosowanie w formulacjach farmaceutycznych i kosmetycznych jako nośniki hydrofobowych substancji aktywnych. Przedmiotem wynalazku jest także sposób wytwarzania lipidowych nanocząstek charakteryzujący się tym, że w pierwszym etapie przygotowuje się fazę wodną stanowiącą mieszaninę surfaktantu o wzorze ogólnym 1 w ilości 0.5 do 5% wag. z wodą, po czym całość podgrzewa się do temperatury w zakresie 65-75°C, i przygotowuje się fazę olejową stanowiącą ciekły lipid w stężeniu od 0 do 7% i stopiony stały lipid o stężeniu od 4 do 14% wagowych całości mieszaniny. W drugim etapie miesza się fazę wodną z fazą olejową, a następnie poddaje działaniu ultradźwięków i otrzymuje opalizującą lub mleczną, termodynamicznie stabilną zawiesinę stałych nanocząstek lipidowych lub nanostrukturalnych nośników lipidowych.The invention discloses lipid nanoparticles stabilized by nonionic surfactants of general formula 1, wherein the straight saturated hydrocarbon chain length R is from 9 to 15 carbon atoms, which are used in pharmaceutical and cosmetic formulations as carriers of hydrophobic active substances. The invention also relates to a process for producing lipid nanoparticles characterized in that in the first stage an aqueous phase is prepared consisting of a surfactant mixture of general formula 1 in an amount of 0.5 to 5 wt. with water, then the whole is heated to a temperature in the range of 65-75 ° C, and an oil phase consisting of a liquid lipid at a concentration of 0 to 7% and a molten solid lipid at a concentration of 4 to 14% by weight of the total mixture are prepared. In the second stage, the aqueous phase is mixed with the oil phase and then subjected to ultrasound to obtain an opalescent or milky, thermodynamically stable suspension of solid lipid nanoparticles or nanostructured lipid carriers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL408053A PL229225B1 (en) | 2014-04-29 | 2014-04-29 | Lipide nanoparticles and method for producing them |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL408053A PL229225B1 (en) | 2014-04-29 | 2014-04-29 | Lipide nanoparticles and method for producing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL408053A1 true PL408053A1 (en) | 2015-04-13 |
| PL229225B1 PL229225B1 (en) | 2018-06-29 |
Family
ID=52781999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL408053A PL229225B1 (en) | 2014-04-29 | 2014-04-29 | Lipide nanoparticles and method for producing them |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL229225B1 (en) |
-
2014
- 2014-04-29 PL PL408053A patent/PL229225B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL229225B1 (en) | 2018-06-29 |
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