PL407598A1 - Apha-hydroxy-methyl-phosphonic acids -- 2-azanor-bornane derivatives and a method for their preparation - Google Patents

Apha-hydroxy-methyl-phosphonic acids -- 2-azanor-bornane derivatives and a method for their preparation

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Publication number
PL407598A1
PL407598A1 PL407598A PL40759814A PL407598A1 PL 407598 A1 PL407598 A1 PL 407598A1 PL 407598 A PL407598 A PL 407598A PL 40759814 A PL40759814 A PL 40759814A PL 407598 A1 PL407598 A1 PL 407598A1
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PL
Poland
Prior art keywords
methyl
azanor
apha
hydroxy
preparation
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Application number
PL407598A
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Polish (pl)
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PL223370B1 (en
Inventor
Tomasz Olszewski
Elżbieta Wojaczyńska
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Politechnika Wrocławska
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Application filed by Politechnika Wrocławska filed Critical Politechnika Wrocławska
Priority to PL407598A priority Critical patent/PL223370B1/en
Publication of PL407598A1 publication Critical patent/PL407598A1/en
Publication of PL223370B1 publication Critical patent/PL223370B1/en

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Abstract

Przedmiotem wynalazku są kwasy ?-hydroksymetylofosfonowe - pochodne 2-azanorbornanu o wzorze ogólnym I, w którym R stanowi grupę (R)-?-metylobenzylową lub (S)-?-metylobenzylową. Sposób wytwarzania kwasów ?-hydroksymetylofosfonowych pochodnych 2-azanorbornanu o wzorze ogólnym, w którym R stanowi grupę (R)-?-metylobenzylową lub (S)-?-metylobenzylową polega na tym, że w pierwszym etapie bromotrimetylosilan (BrTMS) poddaje się reakcji z fosforynem trimetylowym oraz aldehydem 2-azanorbornylowym w stosunku molowych 6:1:1 w temperaturze pokojowej, po czym w drugim etapie produkt reakcji rozpuszcza się w alkoholu metylowym, z którego wydziela się kwasy ?-hydroksymetylofosfonowe - pochodne 2-azanorbornanu w postaci krystalicznej.The present invention relates to β-hydroxymethylphosphonic acids - 2-azanorbornane derivatives of the general formula I, in which R is a (R) -β-methylbenzyl or (S) -β-methylbenzyl group. The method of producing α-hydroxymethylphosphonic acids of 2-azanorbornane derivatives of the general formula in which R is (R) - α - methylbenzyl or (S) - α - methylbenzyl group consists in the first stage of reacting bromotrimethylsilane (BrTMS) with trimethyl phosphite and 2-azanorbornyldehyde in a molar ratio of 6: 1: 1 at room temperature, after which in the second stage the reaction product is dissolved in methyl alcohol from which α-hydroxymethylphosphonic acids - 2-azanorbornane derivatives in crystalline form are separated.

PL407598A 2014-03-21 2014-03-21 Apha-hydroxy-methyl-phosphonic acids -- 2-azanor-bornane derivatives and a method for their preparation PL223370B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL407598A PL223370B1 (en) 2014-03-21 2014-03-21 Apha-hydroxy-methyl-phosphonic acids -- 2-azanor-bornane derivatives and a method for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL407598A PL223370B1 (en) 2014-03-21 2014-03-21 Apha-hydroxy-methyl-phosphonic acids -- 2-azanor-bornane derivatives and a method for their preparation

Publications (2)

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PL407598A1 true PL407598A1 (en) 2014-11-24
PL223370B1 PL223370B1 (en) 2016-10-31

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Family Applications (1)

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PL407598A PL223370B1 (en) 2014-03-21 2014-03-21 Apha-hydroxy-methyl-phosphonic acids -- 2-azanor-bornane derivatives and a method for their preparation

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Publication number Publication date
PL223370B1 (en) 2016-10-31

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