PL405911A1 - Białko o aktywności hydrolitycznej wobec polisacharydowych otoczek bakteryjnych, polinukleotyd kodujący to białko, biologicznie czynny wektor, kompozycja zawierająca białko i jego zastosowanie - Google Patents
Białko o aktywności hydrolitycznej wobec polisacharydowych otoczek bakteryjnych, polinukleotyd kodujący to białko, biologicznie czynny wektor, kompozycja zawierająca białko i jego zastosowanieInfo
- Publication number
- PL405911A1 PL405911A1 PL40591113A PL40591113A PL405911A1 PL 405911 A1 PL405911 A1 PL 405911A1 PL 40591113 A PL40591113 A PL 40591113A PL 40591113 A PL40591113 A PL 40591113A PL 405911 A1 PL405911 A1 PL 405911A1
- Authority
- PL
- Poland
- Prior art keywords
- protein
- hydrolytic activity
- applications
- composition containing
- biologically active
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10211—Podoviridae
- C12N2795/10222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Przedmiotem wynalazku są białka ogonkowe bakteriofaga Klebsiella pneumoniae KP32, uzyskane drogą rekombinacji wykazujące aktywność hydrolityczną w stosunku do polisacharydowych otoczek bakteryjnych. Białka o sekwencjach aminokwasowych oznaczonych SEKW NR 1 - gp31 i SEKW NR 2 - gp32 przeciwdziałają powstawaniu i degradują biofilm tworzony przez szczepy Klebsiella pneumoniae oraz wykazują synergistyczne działanie w zwalczaniu biofilmu tworzonego przez szczepy K.pneumoniae, E.cloacae i S.aureus.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL40591113A PL405911A1 (pl) | 2013-11-04 | 2013-11-04 | Białko o aktywności hydrolitycznej wobec polisacharydowych otoczek bakteryjnych, polinukleotyd kodujący to białko, biologicznie czynny wektor, kompozycja zawierająca białko i jego zastosowanie |
PCT/PL2014/000126 WO2015065209A1 (en) | 2013-11-04 | 2014-11-04 | Protein having hydrolytic activity against bacterial polysaccharide capsules, polynucleotide encoding this protein, biologically active vector, composition containing the protein and its use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL40591113A PL405911A1 (pl) | 2013-11-04 | 2013-11-04 | Białko o aktywności hydrolitycznej wobec polisacharydowych otoczek bakteryjnych, polinukleotyd kodujący to białko, biologicznie czynny wektor, kompozycja zawierająca białko i jego zastosowanie |
Publications (1)
Publication Number | Publication Date |
---|---|
PL405911A1 true PL405911A1 (pl) | 2015-05-11 |
Family
ID=52101558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL40591113A PL405911A1 (pl) | 2013-11-04 | 2013-11-04 | Białko o aktywności hydrolitycznej wobec polisacharydowych otoczek bakteryjnych, polinukleotyd kodujący to białko, biologicznie czynny wektor, kompozycja zawierająca białko i jego zastosowanie |
Country Status (2)
Country | Link |
---|---|
PL (1) | PL405911A1 (pl) |
WO (1) | WO2015065209A1 (pl) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113755469B (zh) * | 2021-11-09 | 2022-02-22 | 上海瑞宙生物科技有限公司 | 肺炎克雷伯菌荚膜多糖解聚酶及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4822740A (en) | 1985-10-07 | 1989-04-18 | Microlife Technics, Inc. | Bacteria for expressing a polysaccharide depolymerase containing a novel recombinant plasmid |
EP1663265B1 (en) | 2003-07-23 | 2015-09-23 | Biocontrol Limited | Bacteriophage-containing therapeutic agents |
WO2006063176A2 (en) | 2004-12-06 | 2006-06-15 | The Government Of The Usa As Representedtd By The Secretary Of The Dept Of Health And Human Services | Inhibition of biofilm formation using bacteriophage |
KR100910961B1 (ko) | 2007-09-13 | 2009-08-05 | 주식회사 인트론바이오테크놀로지 | 황색포도상구균의 균막 처치에 효과적인 박테리오파지 또는그것 유래의 용균단백질 |
WO2010141135A2 (en) | 2009-03-05 | 2010-12-09 | Trustees Of Boston University | Bacteriophages expressing antimicrobial peptides and uses thereof |
-
2013
- 2013-11-04 PL PL40591113A patent/PL405911A1/pl unknown
-
2014
- 2014-11-04 WO PCT/PL2014/000126 patent/WO2015065209A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2015065209A1 (en) | 2015-05-07 |
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