PL402440A1 - Zmodyfikowany gen ludzkiej deaminazy cytydyny indukowanej aktywacją limfocytów B (AID), sposób modyfikacji genu ludzkiej AID, preparat wykazujący aktywność AID oraz sposób otrzymywania tego preparatu w systemie bakteryjnym - Google Patents
Zmodyfikowany gen ludzkiej deaminazy cytydyny indukowanej aktywacją limfocytów B (AID), sposób modyfikacji genu ludzkiej AID, preparat wykazujący aktywność AID oraz sposób otrzymywania tego preparatu w systemie bakteryjnymInfo
- Publication number
- PL402440A1 PL402440A1 PL402440A PL40244013A PL402440A1 PL 402440 A1 PL402440 A1 PL 402440A1 PL 402440 A PL402440 A PL 402440A PL 40244013 A PL40244013 A PL 40244013A PL 402440 A1 PL402440 A1 PL 402440A1
- Authority
- PL
- Poland
- Prior art keywords
- aid
- gene
- human
- preparation
- activity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04005—Cytidine deaminase (3.5.4.5)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Przedmiotem wynalazku jest zmodyfikowany gen ludzkiej deaminazy cytydyny indukowanej aktywacją limfocytów B (AID), sposób modyfikacji genu ludzkiej AID, preparat wykazujący aktywność AID oraz sposób wytwarzania tego preparatu. Wynalazek dotyczy zmodyfikowanego genu ludzkiej AID, umożliwiającego produkcję aktywnego enzymu w systemie bakteryjnym.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL402440A PL225333B1 (pl) | 2013-01-14 | 2013-01-14 | Preparat wykazujący aktywność ludzkiej deaminazy cytydyny indukowanej aktywacją limfocytów B (AID) oraz sposób otrzymywania tego preparatu w systemie bakteryjnym |
PCT/PL2014/000003 WO2014109656A1 (en) | 2013-01-14 | 2014-01-14 | Modified gene of human activation-induced cytidine deaminase (aid), a method of modification of human aid gene, a composition showing aid activity, a method of preparation of such composition in a bacterial system and use of the composition in the analyses of dna/rna amination/deamination and/or methylation/demethylation |
US14/384,665 US20150044675A1 (en) | 2013-01-14 | 2014-01-14 | Modified gene of human activation-induced cytidine deaminase (aid), a method of modification of human aid gene, a composition showing aid activity, a method of preparation of such composition in a bacterial system and use of the composition in the analyses of dna/rna amination/deamination and/or methylation/demethylation |
EP14703938.2A EP2870241B1 (en) | 2013-01-14 | 2014-01-14 | A composition showing activation-induced cytidine deaminase (aid) activity, a method of preparation of such composition in a bacterial system and use of the composition in the analyses of dna/rna amination/deamination and/or methylation/demethylation |
DK14703938.2T DK2870241T3 (en) | 2013-01-14 | 2014-01-14 | COMPOSITION EXISTING ACTIVITY-INDUCED CYTIDINE DAMINASE (AID) ACTIVITY, PROCEDURE FOR PROVIDING THIS COMPOSITION IN A BACTERIAL SYSTEM AND USING THE COMPOSITION / DEVELOPMENT / ANALYSIS OF ANALYZE / DEVELOPMENT / ANALYZE / ANALYZE COMPOSITION |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL402440A PL225333B1 (pl) | 2013-01-14 | 2013-01-14 | Preparat wykazujący aktywność ludzkiej deaminazy cytydyny indukowanej aktywacją limfocytów B (AID) oraz sposób otrzymywania tego preparatu w systemie bakteryjnym |
Publications (2)
Publication Number | Publication Date |
---|---|
PL402440A1 true PL402440A1 (pl) | 2014-07-21 |
PL225333B1 PL225333B1 (pl) | 2017-03-31 |
Family
ID=50073407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL402440A PL225333B1 (pl) | 2013-01-14 | 2013-01-14 | Preparat wykazujący aktywność ludzkiej deaminazy cytydyny indukowanej aktywacją limfocytów B (AID) oraz sposób otrzymywania tego preparatu w systemie bakteryjnym |
Country Status (5)
Country | Link |
---|---|
US (1) | US20150044675A1 (pl) |
EP (1) | EP2870241B1 (pl) |
DK (1) | DK2870241T3 (pl) |
PL (1) | PL225333B1 (pl) |
WO (1) | WO2014109656A1 (pl) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2228378A1 (en) * | 1995-07-31 | 1997-02-13 | Centre De Recherche De L'hopital Sainte-Justine | Cytidine deaminase cdna as a positive selectable marker for gene transfer, gene therapy and protein synthesis |
EP1575992A4 (en) * | 2002-08-05 | 2007-02-21 | Univ Rochester | CHIMERIC PROTEINS WITH PROTEIN TRANSDUCTION FIELD / DOMAINE DESAMINASE, ASSOCIATED COMPOUNDS AND CORRESPONDING USES |
RU2537264C2 (ru) * | 2009-04-03 | 2014-12-27 | Медикал Рисерч Каунсил | Мутанты индуцируемой активацией цитидиндеаминазы (aid) и способы их применения |
-
2013
- 2013-01-14 PL PL402440A patent/PL225333B1/pl unknown
-
2014
- 2014-01-14 WO PCT/PL2014/000003 patent/WO2014109656A1/en active Application Filing
- 2014-01-14 EP EP14703938.2A patent/EP2870241B1/en active Active
- 2014-01-14 US US14/384,665 patent/US20150044675A1/en not_active Abandoned
- 2014-01-14 DK DK14703938.2T patent/DK2870241T3/en active
Also Published As
Publication number | Publication date |
---|---|
EP2870241B1 (en) | 2018-03-14 |
PL225333B1 (pl) | 2017-03-31 |
US20150044675A1 (en) | 2015-02-12 |
EP2870241A1 (en) | 2015-05-13 |
DK2870241T3 (en) | 2018-06-06 |
WO2014109656A1 (en) | 2014-07-17 |
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