PL4010344T3 - Pochodne tienopirymidyny jako inhibitory acc i ich zastosowanie - Google Patents
Pochodne tienopirymidyny jako inhibitory acc i ich zastosowanieInfo
- Publication number
- PL4010344T3 PL4010344T3 PL20760689.8T PL20760689T PL4010344T3 PL 4010344 T3 PL4010344 T3 PL 4010344T3 PL 20760689 T PL20760689 T PL 20760689T PL 4010344 T3 PL4010344 T3 PL 4010344T3
- Authority
- PL
- Poland
- Prior art keywords
- acc inhibitors
- thienopyrimidine derivatives
- thienopyrimidine
- derivatives
- acc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962885038P | 2019-08-09 | 2019-08-09 | |
| PCT/US2020/045192 WO2021030142A1 (en) | 2019-08-09 | 2020-08-06 | Thienopyrimidine derivatives as acc inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4010344T3 true PL4010344T3 (pl) | 2025-03-03 |
Family
ID=72179238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20760689.8T PL4010344T3 (pl) | 2019-08-09 | 2020-08-06 | Pochodne tienopirymidyny jako inhibitory acc i ich zastosowanie |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11352371B2 (pl) |
| EP (2) | EP4010344B1 (pl) |
| JP (1) | JP7394961B2 (pl) |
| KR (1) | KR102826192B1 (pl) |
| CN (1) | CN114206884B (pl) |
| AR (1) | AR119594A1 (pl) |
| AU (1) | AU2020327926B2 (pl) |
| CA (1) | CA3147913A1 (pl) |
| ES (1) | ES2994667T3 (pl) |
| PL (1) | PL4010344T3 (pl) |
| TW (1) | TWI777214B (pl) |
| WO (1) | WO2021030142A1 (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201702041PA (en) | 2015-07-06 | 2017-04-27 | Gilead Sciences Inc | Cot modulators and methods of use thereof |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| CN115397511A (zh) | 2020-03-30 | 2022-11-25 | 吉利德科学公司 | Cot抑制剂化合物(s)-6-(((1-(双环[1.1.1]戊-1-基)-1h-1,2,3-三唑-4-基)2-甲基-1-氧代-1,2-二氢异喹啉-5-基)甲基)))氨基8-氯-(新戊基氨基)喹啉-3-甲腈的固体形式 |
| US11845737B2 (en) | 2020-04-02 | 2023-12-19 | Gilead Sciences, Inc. | Process for preparing a Cot inhibitor compound |
| TW202304435A (zh) | 2021-06-04 | 2023-02-01 | 美商基利科學股份有限公司 | 治療ｎａｓｈ之方法 |
| TW202311256A (zh) | 2021-06-18 | 2023-03-16 | 美商基利科學股份有限公司 | 用於治療ｆｘｒ誘發之搔癢之ｉｌ－３１調節劑 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1674480A4 (en) | 2003-09-04 | 2007-06-20 | Riken | ANTIBODY RECOGNIZING THE REGIONAL SECTION CONTROLLING TGF-BETA ACTIVATION |
| US20070276050A1 (en) | 2006-02-27 | 2007-11-29 | Gilead Sciences, Inc. | Methods for identifying ASK1 inhibitors useful for preventing and/or treating cardiovascular diseases |
| TWI625121B (zh) | 2009-07-13 | 2018-06-01 | 基利科學股份有限公司 | 調節細胞凋亡信號之激酶的抑制劑 |
| RS57157B1 (sr) | 2011-11-11 | 2018-07-31 | Gilead Apollo Llc | Acc inhibitori i njihove primene |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| EP2822592B1 (en) | 2012-03-08 | 2018-08-15 | Ludwig Institute for Cancer Research Limited | Tgf- 1 specific antibodies and methods and uses thereof |
| JP6417403B2 (ja) | 2013-05-10 | 2018-11-07 | ギリアド アポロ， エルエルシー | Ａｃｃ阻害剤及びその使用 |
| EP2994139B1 (en) | 2013-05-10 | 2019-04-10 | Gilead Apollo, LLC | Acc inhibitors and uses thereof |
| BR112015028173A2 (pt) | 2013-05-10 | 2017-07-25 | Nimbus Apollo Inc | inibidores de acc e usos dos mesmos |
| EP2994138A4 (en) | 2013-05-10 | 2016-12-28 | Nimbus Apollo Inc | ACC-HEMMER AND USES THEREOF |
| JP2016529892A (ja) | 2013-08-01 | 2016-09-29 | ユニベルシテ カソリク デ ロウバイン | 抗ｇａｒｐタンパク質及びその使用 |
| EA201892625A1 (ru) | 2015-01-09 | 2019-07-31 | Джилид Аполло, Ллс | КОМБИНИРОВАННАЯ ТЕРАПИЯ С ПРИМЕНЕНИЕМ ИНГИБИТОРА АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ (ACC) ДЛЯ ЛЕЧЕНИЯ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ |
| WO2016115345A1 (en) | 2015-01-14 | 2016-07-21 | The Brigham And Women's Hospital, | Treatment of cancer with anti-lap monoclonal antibodies |
| AR106472A1 (es) | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| KR20180082558A (ko) | 2015-11-25 | 2018-07-18 | 길리어드 아폴로, 엘엘씨 | 에스테르 acc 억제제 및 그의 용도 |
| MX2018006287A (es) | 2015-11-25 | 2018-09-07 | Gilead Apollo Llc | Inhibidores de acc de triazol y usos de los mismos. |
| AU2016361412A1 (en) | 2015-11-25 | 2018-05-24 | Gilead Apollo, Llc | Pyrazole ACC inhibitors and uses thereof |
| ES2943235T3 (es) | 2015-11-25 | 2023-06-12 | Gilead Apollo Llc | Composiciones fungicidas que contienen derivados de 2,4-dioxo-1,4-dihidrotieno[2,3-d]pirimidina |
| CN108699078A (zh) | 2016-03-02 | 2018-10-23 | 吉利德阿波罗公司 | 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法 |
| WO2018129329A1 (en) | 2017-01-06 | 2018-07-12 | Scholar Rock, Inc. | ISOFORM-SPECIFIC, CONTEXT-PERMISSIVE TGFβ1 INHIBITORS AND USE THEREOF |
| EP3571205B1 (en) | 2017-01-22 | 2023-08-30 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
| ES2963841T3 (es) | 2017-03-03 | 2024-04-02 | Gilead Sciences Inc | Procesos para preparar inhibidores de ACC y formas sólidas del mismo |
| WO2018161008A1 (en) | 2017-03-03 | 2018-09-07 | Gilead Apollo, Llc | Processes for the preparation of fungicidal compounds |
| EP4122464B1 (en) | 2017-03-28 | 2024-05-15 | Gilead Sciences, Inc. | Therapeutic combinations for treating liver diseases |
| JP7067725B2 (ja) * | 2017-07-17 | 2022-05-16 | ナンジン ルイジエ ファーマテック カンパニー， リミテッド | Ａｃｃ阻害剤としての新規な化合物およびそれらの使用 |
| EP3691648A1 (en) | 2017-10-06 | 2020-08-12 | Gilead Sciences, Inc. | Combination therapy comprising an acc inhibitor |
| WO2019072478A1 (en) | 2017-10-10 | 2019-04-18 | Galderma Research & Development | SPECIFIC ACETYL-COA CARBOXYLASE INHIBITORS FOR USE IN THE TREATMENT AND / OR PREVENTION OF ACNE |
| WO2019113123A1 (en) | 2017-12-04 | 2019-06-13 | Precithera, Inc. | TGF-ß RECEPTOR FUSION PROTEINS AND OTHER TGF-ß ANTAGONISTS FOR REDUCING TGF-ß SIGNALING |
| WO2019113464A1 (en) | 2017-12-08 | 2019-06-13 | Elstar Therapeutics, Inc. | Multispecific molecules and uses thereof |
-
2020
- 2020-08-05 AR ARP200102218A patent/AR119594A1/es not_active Application Discontinuation
- 2020-08-06 ES ES20760689T patent/ES2994667T3/es active Active
- 2020-08-06 US US16/986,909 patent/US11352371B2/en active Active
- 2020-08-06 PL PL20760689.8T patent/PL4010344T3/pl unknown
- 2020-08-06 AU AU2020327926A patent/AU2020327926B2/en active Active
- 2020-08-06 CA CA3147913A patent/CA3147913A1/en active Pending
- 2020-08-06 WO PCT/US2020/045192 patent/WO2021030142A1/en not_active Ceased
- 2020-08-06 KR KR1020227007443A patent/KR102826192B1/ko active Active
- 2020-08-06 TW TW109126651A patent/TWI777214B/zh active
- 2020-08-06 EP EP20760689.8A patent/EP4010344B1/en active Active
- 2020-08-06 EP EP24203945.1A patent/EP4545535A1/en active Pending
- 2020-08-06 CN CN202080056226.7A patent/CN114206884B/zh active Active
- 2020-08-06 JP JP2022507831A patent/JP7394961B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN114206884A (zh) | 2022-03-18 |
| JP7394961B2 (ja) | 2023-12-08 |
| EP4010344C0 (en) | 2024-10-02 |
| EP4010344B1 (en) | 2024-10-02 |
| EP4010344A1 (en) | 2022-06-15 |
| TWI777214B (zh) | 2022-09-11 |
| CN114206884B (zh) | 2024-07-12 |
| TW202120512A (zh) | 2021-06-01 |
| KR102826192B1 (ko) | 2025-06-27 |
| WO2021030142A1 (en) | 2021-02-18 |
| AU2020327926A1 (en) | 2022-02-17 |
| AR119594A1 (es) | 2021-12-29 |
| US20210053990A1 (en) | 2021-02-25 |
| US11352371B2 (en) | 2022-06-07 |
| ES2994667T3 (en) | 2025-01-29 |
| CA3147913A1 (en) | 2021-02-18 |
| AU2020327926B2 (en) | 2023-04-13 |
| JP2022544199A (ja) | 2022-10-17 |
| KR20220044782A (ko) | 2022-04-11 |
| EP4545535A1 (en) | 2025-04-30 |
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