PL400412A1 - 1-methylpiperidinium ionic liquids with the theophylline anion and a method for their preparation - Google Patents
1-methylpiperidinium ionic liquids with the theophylline anion and a method for their preparationInfo
- Publication number
- PL400412A1 PL400412A1 PL400412A PL40041212A PL400412A1 PL 400412 A1 PL400412 A1 PL 400412A1 PL 400412 A PL400412 A PL 400412A PL 40041212 A PL40041212 A PL 40041212A PL 400412 A1 PL400412 A1 PL 400412A1
- Authority
- PL
- Poland
- Prior art keywords
- theophylline
- methylpiperidinium
- anion
- ionic liquids
- residue
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Przedmiotem wynalazku sa 1-metylopiperydyniowe ciecze jonowe z anionem teofiliniowym o wzorze ogólnym 1, w którym R oznacza prosto lancuchowa grupe alkilowa zawierajaca od 1 do 20 atomów wegla, lub proton, lub grupe arylowa, lub allilowa, lub winylowa, lub chloroetylowa, lub hydroksyetylowa, lub benzylowa, majace zastosowanie jako zwiazki powierzchniowo czynne. W odmianie sposób ich wytwarzania polega na tym, ze sól teofiliny o wzorze ogólnym 2, w której M oznacza atom litu, lub sodu, lub potasu, lub srebra, lub grupe NH4, poddaje sie reakcji z czwartorzedowym halogenkiem 1-metylopipe-rydyniowym o wzorze ogólnym 3, w którym X oznacza chlor, lub brom, lub jod w stosunku molowym 1:0,8-1,5 w rozpuszczalniku organicznym. Calosc miesza sie w temperaturze od 273 do 363K, w czasie co najmniej 15 minut, po czym oddziela roztwór od powstajacego osadu, który stanowi sól nieorganiczna. Nastepnie odparowuje sie rozpuszczalnik organiczny. Pozostalosc przemywa bezwodnym acetonem do usuniecia pozostalosci soli oraz nadmiaru nieprzereagowanej teofiliny, dalej pozostalosc suszy sie pod obnizonym cisnieniem w temperaturze 303 do 343 K, w czasie co najmniej 15 minut.The subject of the invention are 1-methylpiperidinium ionic liquids with theophylline anion of general formula 1, wherein R is a straight chain alkyl group containing from 1 to 20 carbon atoms, or a proton, or an aryl, or allyl, or vinyl, or chloroethyl or hydroxyethyl group or benzyl, which may be used as surfactants. In a variation, the method of their preparation consists in reacting theophylline salt of general formula II, in which M is lithium, or sodium, or potassium, or silver, or NH4, with a 1-methyl piperidinium quaternary halide of formula general 3, wherein X is chlorine, or bromine, or iodine in a molar ratio of 1: 0.8-1.5 in an organic solvent. The whole is stirred at a temperature of 273 to 363K for at least 15 minutes, then separates the solution from the resulting precipitate, which is the inorganic salt. The organic solvent is then evaporated. The residue is washed with anhydrous acetone to remove salt residues and excess unreacted theophylline, then the residue is dried under reduced pressure at 303 to 343 K for at least 15 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL400412A PL223215B1 (en) | 2012-08-16 | 2012-08-16 | 1-methylpiperidinium ionic liquids with the theophylline anion and a method for their preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL400412A PL223215B1 (en) | 2012-08-16 | 2012-08-16 | 1-methylpiperidinium ionic liquids with the theophylline anion and a method for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL400412A1 true PL400412A1 (en) | 2014-02-17 |
| PL223215B1 PL223215B1 (en) | 2016-10-31 |
Family
ID=50097354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL400412A PL223215B1 (en) | 2012-08-16 | 2012-08-16 | 1-methylpiperidinium ionic liquids with the theophylline anion and a method for their preparation |
Country Status (1)
| Country | Link |
|---|---|
| PL (1) | PL223215B1 (en) |
-
2012
- 2012-08-16 PL PL400412A patent/PL223215B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL223215B1 (en) | 2016-10-31 |
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