PL399447A1 - Szczepionka do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnazania komórek Treg do wytwarzania szczepionki do leczenia cukrzycy typu 1 - Google Patents

Szczepionka do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnazania komórek Treg do wytwarzania szczepionki do leczenia cukrzycy typu 1

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Publication number
PL399447A1
PL399447A1 PL399447A PL39944712A PL399447A1 PL 399447 A1 PL399447 A1 PL 399447A1 PL 399447 A PL399447 A PL 399447A PL 39944712 A PL39944712 A PL 39944712A PL 399447 A1 PL399447 A1 PL 399447A1
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PL
Poland
Prior art keywords
vaccine
diabetes
treatment
type
children
Prior art date
Application number
PL399447A
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English (en)
Other versions
PL218400B1 (pl
Inventor
Piotr Trzonkowski
Małgorzata Myśliwiec
Natalia Marek-Trzonkowska
Original Assignee
Gdanski Uniwersytet Medyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Gdanski Uniwersytet Medyczny filed Critical Gdanski Uniwersytet Medyczny
Priority to PL399447A priority Critical patent/PL218400B1/pl
Priority to ES13739523T priority patent/ES2807279T3/es
Priority to SI201331762T priority patent/SI2859092T1/sl
Priority to DK13739523.2T priority patent/DK2859092T3/da
Priority to EP13739523.2A priority patent/EP2859092B1/en
Priority to HUE13739523A priority patent/HUE057439T2/hu
Priority to US14/405,906 priority patent/US20150165007A1/en
Priority to PCT/PL2013/000072 priority patent/WO2013184011A1/en
Priority to PL13739523T priority patent/PL2859092T3/pl
Priority to LTEP13739523.2T priority patent/LT2859092T/lt
Priority to PT137395232T priority patent/PT2859092T/pt
Publication of PL399447A1 publication Critical patent/PL399447A1/pl
Publication of PL218400B1 publication Critical patent/PL218400B1/pl
Priority to US15/852,227 priority patent/US11944672B2/en
Priority to US16/661,038 priority patent/US20200054724A1/en
Priority to HRP20201177TT priority patent/HRP20201177T1/hr
Priority to CY20201101056T priority patent/CY1123467T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells

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  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
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  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Przedmiotem wynalazku jest szczepionka do leczenia cukrzycy typu 1 u dzieci, która zawiera limfocyty Treg CD3(+)CD4(+)CD25(high)CD127(-). Ponadto ujawniono sorter komórek do wytwarzania tej szczepionki oraz sposób namnazania komórek Treg in vitro.
PL399447A 2012-06-06 2012-06-06 Szczepionka do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnażania komórek Treg in vitro do wytwarzania szczepionki do leczenia cukrzycy typu 1 PL218400B1 (pl)

Priority Applications (15)

Application Number Priority Date Filing Date Title
PL399447A PL218400B1 (pl) 2012-06-06 2012-06-06 Szczepionka do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnażania komórek Treg in vitro do wytwarzania szczepionki do leczenia cukrzycy typu 1
PCT/PL2013/000072 WO2013184011A1 (en) 2012-06-06 2013-06-04 Therapeutic vaccine for treatment of diabetes type 1 in children, application of the cell sorter and the method of multiplying treg cells to produce therapeutic vaccine for treatment of diabetes type 1
PL13739523T PL2859092T3 (pl) 2012-06-06 2013-06-04 Szczepionka terapeutyczna do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnażania komórek Treg do wytwarzania szczepionki do leczenia cukrzycy typu 1
DK13739523.2T DK2859092T3 (da) 2012-06-06 2013-06-04 Terapeutisk vaccine til behandling af diabetes type-1 hos børn, anvendelse af cellesorter og fremgangsmåde til at multiplicere treg-celler til fremstilling af terapeutisk vaccine til behandling af diabetes type-1
EP13739523.2A EP2859092B1 (en) 2012-06-06 2013-06-04 Therapeutic vaccine for treatment of diabetes type 1 in children, application of the cell sorter and the method of multiplying treg cells to produce therapeutic vaccine for treatment of diabetes type 1
HUE13739523A HUE057439T2 (hu) 2012-06-06 2013-06-04 Terápiás vakcina 1-es típusú cukorbetegség kezelésére gyermekekben, sejtválogató alkalmazása és eljárás TREG sejtek sokszorosítására 1-es típusú cukorbetegség kezelésére szolgáló terápiás vakcina elõállítására
US14/405,906 US20150165007A1 (en) 2012-06-06 2013-06-04 Therapeutic vaccine for treatment of diabetes type 1 in children, application of the cell sorter and the method of multiplying treg cells to produce therapeutic vaccine for treatment of diabetes type 1
ES13739523T ES2807279T3 (es) 2012-06-06 2013-06-04 Vacuna terapéutica para el tratamiento de la diabetes de tipo 1 en niños, aplicación del separador celular y método de multiplicación de células Treg para producir vacuna terapéutica para el tratamiento de la diabetes de tipo 1
SI201331762T SI2859092T1 (sl) 2012-06-06 2013-06-04 Terapevtsko cepivo za zdravljenje diabetesa tipa 1 pri otrocih, uporaba naprave za sortiranje celic in postopek multipliciranja TREG celic za pridobivanje terapevtskega cepiva za zdravljenje diabetesa tipa 1
LTEP13739523.2T LT2859092T (lt) 2012-06-06 2013-06-04 Terapinė vakcina, skirta vaikų 1 tipo diabeto gydymui, ląstelių sorterio taikymas ir treg ląstelių dauginimo būdas, siekiant gaminti terapinę vakciną 1 tipo diabeto gydymui
PT137395232T PT2859092T (pt) 2012-06-06 2013-06-04 ¿vacina terapêutica para tratamento de diabetes tipo 1 em crianças, aplicação do separador de células e método de multiplicação de células treg para produzir a vacina terapêutica para tratamento de diabetes tipo 1¿
US15/852,227 US11944672B2 (en) 2012-06-06 2017-12-22 Therapeutic vaccine for treatment of diabetes type 1 in children, application of the cell sorter and the method of multiplying Treg cells to produce therapeutic vaccine for treatment of diabetes type 1
US16/661,038 US20200054724A1 (en) 2012-06-06 2019-10-23 Therapeutic vaccine for treatment of diabetes type 1 in children, application of the cell sorter and the method of multiplying treg cells to produce therapeutic vaccine for treatment of diabetes type 1
HRP20201177TT HRP20201177T1 (hr) 2012-06-06 2020-07-28 Terapijsko cjepivo za liječenje dijabetesa tipa 1 kod djece, primjena staničnog sortera i metoda umnožavanja treg stanica za proizvodnju terapijskog cjepiva za liječenje dijabetesa tipa 1
CY20201101056T CY1123467T1 (el) 2012-06-06 2020-07-29 Θεραπευτικο εμβολιο για τη θεραπεια του παιδικου διαβητη τυπου 1, εφαρμογη του κυτταροδιαχωριστη κυτταρομετριας ροης και της μεθοδου πολλαπλασιασμου των κυτταρων treg για την παραγωγη θεραπευτικου εμβολιου για τη θεραπεια του διαβητη τυπου 1

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL399447A PL218400B1 (pl) 2012-06-06 2012-06-06 Szczepionka do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnażania komórek Treg in vitro do wytwarzania szczepionki do leczenia cukrzycy typu 1

Publications (2)

Publication Number Publication Date
PL399447A1 true PL399447A1 (pl) 2013-12-09
PL218400B1 PL218400B1 (pl) 2014-11-28

Family

ID=48808489

Family Applications (2)

Application Number Title Priority Date Filing Date
PL399447A PL218400B1 (pl) 2012-06-06 2012-06-06 Szczepionka do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnażania komórek Treg in vitro do wytwarzania szczepionki do leczenia cukrzycy typu 1
PL13739523T PL2859092T3 (pl) 2012-06-06 2013-06-04 Szczepionka terapeutyczna do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnażania komórek Treg do wytwarzania szczepionki do leczenia cukrzycy typu 1

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL13739523T PL2859092T3 (pl) 2012-06-06 2013-06-04 Szczepionka terapeutyczna do leczenia cukrzycy typu 1 u dzieci, zastosowanie sortera komórek oraz sposób namnażania komórek Treg do wytwarzania szczepionki do leczenia cukrzycy typu 1

Country Status (12)

Country Link
US (3) US20150165007A1 (pl)
EP (1) EP2859092B1 (pl)
CY (1) CY1123467T1 (pl)
DK (1) DK2859092T3 (pl)
ES (1) ES2807279T3 (pl)
HR (1) HRP20201177T1 (pl)
HU (1) HUE057439T2 (pl)
LT (1) LT2859092T (pl)
PL (2) PL218400B1 (pl)
PT (1) PT2859092T (pl)
SI (1) SI2859092T1 (pl)
WO (1) WO2013184011A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170232084A1 (en) 2013-04-26 2017-08-17 Enzo Biochem Inc. Immune modulation for the treatment of age-related macular degeneration
PL236046B1 (pl) 2015-12-17 2020-11-30 Gdanski Univ Medyczny Sposób namnażania in vitro limfocytów T regulatorowych CD4+ FoxP3+
US20220204931A1 (en) * 2019-04-30 2022-06-30 The Regents Of The University Of California Bead-free ex-vivo expansion of human regulatory t cells
EP3985106A1 (en) 2020-10-16 2022-04-20 Uniwersytet Gdanski Conditioned regulatory t cell population with enhanced therapeutic potential, method for obtaining of regulatory t cell population and the medical use of regulatory t cell population
EP3985105A1 (en) 2020-10-16 2022-04-20 Uniwersytet Gdanski Conditioned regulatory t cell population tregs with enhanced therapeutic potential, method for obtaining of conditioned tregs and the medical use of the tregs population

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526651A (ja) 2003-06-02 2006-11-24 マーシア・ファーマ・インコーポレイテッド １型糖尿病の処置のための治療的ワクチン組成物
JP2006280307A (ja) * 2005-04-01 2006-10-19 Kyoto Univ 制御性ｔ細胞の製造方法
EP1928479B1 (en) * 2005-08-24 2016-06-08 Yeda Research And Development Co., Ltd. Universal donor-derived tolerogenic cells for inducing non-syngeneic transplantation tolerance
US20090208471A1 (en) * 2006-04-07 2009-08-20 Yun Theodore J Isolation and Use of Human Regulatory T Cells
WO2007127787A2 (en) * 2006-04-25 2007-11-08 Joslin Diabetes Center, Inc. Insulin autoantigen-specific regulatory cd4+ t cells
EP2402029A1 (en) 2010-07-01 2012-01-04 Sanofi Pasteur Enterovirus vaccines for preventing or treating type 1 diabetes (III)
EP2402028A1 (en) 2010-07-01 2012-01-04 Sanofi Pasteur Enterovirus vaccines for preventing and treating type 1 diabetes (II)
US9481866B2 (en) * 2011-12-16 2016-11-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing T cell populations enriched for stable regulatory T-cells

Also Published As

Publication number Publication date
HUE057439T2 (hu) 2022-05-28
EP2859092A1 (en) 2015-04-15
ES2807279T3 (es) 2021-02-22
EP2859092B1 (en) 2020-04-29
PT2859092T (pt) 2020-07-23
WO2013184011A1 (en) 2013-12-12
US20200054724A1 (en) 2020-02-20
SI2859092T1 (sl) 2021-02-26
US20180117134A1 (en) 2018-05-03
PL2859092T3 (pl) 2020-11-16
US20150165007A1 (en) 2015-06-18
US11944672B2 (en) 2024-04-02
HRP20201177T1 (hr) 2021-02-19
LT2859092T (lt) 2020-09-25
CY1123467T1 (el) 2022-03-24
DK2859092T3 (da) 2020-07-27
PL218400B1 (pl) 2014-11-28

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