PL3985000T3 - 2,4-dipodstawiona pochodna pirymidyny, sposób jej otrzymywania i zastosowanie - Google Patents

2,4-dipodstawiona pochodna pirymidyny, sposób jej otrzymywania i zastosowanie

Info

Publication number
PL3985000T3
PL3985000T3 PL20831763.6T PL20831763T PL3985000T3 PL 3985000 T3 PL3985000 T3 PL 3985000T3 PL 20831763 T PL20831763 T PL 20831763T PL 3985000 T3 PL3985000 T3 PL 3985000T3
Authority
PL
Poland
Prior art keywords
preparation
same
pyrimidine derivative
disubstituted pyrimidine
disubstituted
Prior art date
Application number
PL20831763.6T
Other languages
English (en)
Inventor
Lijuan Chen
Original Assignee
Chengdu Zenitar Biomedical Technology Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Zenitar Biomedical Technology Co., Ltd. filed Critical Chengdu Zenitar Biomedical Technology Co., Ltd.
Publication of PL3985000T3 publication Critical patent/PL3985000T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
PL20831763.6T 2019-06-28 2020-06-28 2,4-dipodstawiona pochodna pirymidyny, sposób jej otrzymywania i zastosowanie PL3985000T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910577919 2019-06-28
PCT/CN2020/098523 WO2020259683A1 (zh) 2019-06-28 2020-06-28 2，4-二取代嘧啶衍生物及其制备方法和用途

Publications (1)

Publication Number Publication Date
PL3985000T3 true PL3985000T3 (pl) 2025-03-10

Family

ID=74060742

Family Applications (1)

Application Number Title Priority Date Filing Date
PL20831763.6T PL3985000T3 (pl) 2019-06-28 2020-06-28 2,4-dipodstawiona pochodna pirymidyny, sposób jej otrzymywania i zastosowanie

Country Status (14)

Country Link
US (1) US12428394B2 (pl)
EP (1) EP3985000B1 (pl)
CN (1) CN114423750B (pl)
DK (1) DK3985000T3 (pl)
ES (1) ES3000079T3 (pl)
FI (1) FI3985000T3 (pl)
HR (1) HRP20241633T1 (pl)
HU (1) HUE069356T2 (pl)
LT (1) LT3985000T (pl)
PL (1) PL3985000T3 (pl)
PT (1) PT3985000T (pl)
RS (1) RS66292B1 (pl)
SI (1) SI3985000T1 (pl)
WO (1) WO2020259683A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023517519A (ja) * 2020-03-02 2023-04-26 シロナックス・リミテッド フェロトーシス阻害剤ジアリールアミンパラアセトアミド類
CN114790152B (zh) * 2021-01-26 2024-03-26 浙江大学 一种2-氰基丙烯酸酯类化合物及其制备方法和应用
CN113413389B (zh) * 2021-07-19 2024-03-15 成都赜灵生物医药科技有限公司 一种组蛋白去乙酰化酶抑制剂的制剂及其制备方法和用途
TW202317106A (zh) * 2021-08-27 2023-05-01 南韓商柳韓洋行 作為egfr抑制劑之取代胺基吡啶化合物
TW202317105A (zh) 2021-08-27 2023-05-01 南韓商柳韓洋行 作為egfr抑制劑之含六員雜芳基之胺基吡啶化合物
AU2022361055A1 (en) * 2021-10-06 2024-04-04 Alcon Inc. Janus kinase inhibiting pyrazole compounds and uses thereof
CN113999210B (zh) * 2021-12-03 2023-05-23 郑州大学第一附属医院 一组2-苯氨基-4-三氮唑基嘧啶类衍生物及其应用
CN115005214B (zh) * 2022-07-08 2023-03-28 浙江大学 一种用于防治作物镰刀菌病害的高效杀菌组合物
CN115005213B (zh) * 2022-07-05 2023-03-31 浙江大学 一种杀菌剂组合物及其在作物镰刀菌病害防治中的应用
CN116925053A (zh) * 2023-07-26 2023-10-24 成都赜灵生物医药科技有限公司 甲磺酸普依司他中间体的杂质去除工艺

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03005001A (es) * 2000-12-05 2003-09-05 Vertex Pharma Inhibidores de n- terminal c-jun cinasas (jnk) y otras proteinas cinasas.
CA2446864C (en) * 2001-05-16 2011-02-15 Vertex Pharmaceuticals Incorporated Inhibitors of src and other protein kinases
GB0215844D0 (en) 2002-07-09 2002-08-14 Novartis Ag Organic compounds
GB0520955D0 (en) * 2005-10-14 2005-11-23 Cyclacel Ltd Compound
WO2009064835A1 (en) * 2007-11-16 2009-05-22 Incyte Corporation 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin-2-amines as janus kinase inhibitors
PE20100087A1 (es) 2008-06-25 2010-02-08 Irm Llc Compuestos y composiciones como inhibidores de cinasa
US20200113901A1 (en) * 2017-03-31 2020-04-16 Epizyme, Inc. Methods of using ehmt2 inhibitors
WO2018195450A1 (en) * 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
AU2018353150B2 (en) * 2017-10-18 2024-06-06 Epizyme, Inc. Methods of using EHMT2 inhibitors in treating or preventing blood disorders

Also Published As

Publication number Publication date
PT3985000T (pt) 2025-01-03
LT3985000T (lt) 2025-01-10
SI3985000T1 (sl) 2025-02-28
ES3000079T3 (en) 2025-02-27
RS66292B1 (sr) 2025-01-31
EP3985000B1 (en) 2024-09-25
US12428394B2 (en) 2025-09-30
CN114423750A (zh) 2022-04-29
US20220298140A1 (en) 2022-09-22
EP3985000A4 (en) 2022-08-31
CN114423750B (zh) 2024-04-19
HUE069356T2 (hu) 2025-03-28
DK3985000T3 (da) 2024-12-16
FI3985000T3 (fi) 2024-12-17
EP3985000A1 (en) 2022-04-20
WO2020259683A1 (zh) 2020-12-30
HRP20241633T1 (hr) 2025-02-14

Similar Documents

Publication Publication Date Title
LT3985000T (lt) 2,4-dipakeistasis pirimidino darinys, jo gamybos būdas ir panaudojimas
IL288104A (en) Heterocyclic compounds, preparation methods and their use
SG11202106706TA (en) Heterocyclic compound intermediate, preparation method therefor and application thereof
SG11202105850YA (en) Diphenyl-like compound, intermediate thereof, preparation method therefor, pharmaceutical composition thereof and uses thereof
EP3889152A4 (en) HETEROAROMATIC DERIVATIVES FOR USE AS REGULATORS, PROCESS FOR THEIR PREPARATION AND THEIR USE
EP3444246A4 (en) 2,4-DISUBSTITUTED PYRIMIDINE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF
SG11202110376XA (en) Heteroaryl derivative, method for producing the same, and pharmaceutical composition comprising same as effective component
ZA202005151B (en) Steroid derivative regulators, method for preparing the same, and uses thereof
SG11202011685QA (en) 2,3-dihydro-1h-pyrrolizine-7-formamide derivative and application thereof
SG11202103781TA (en) Products, uses & methods
EP3330258A4 (en) 1, 3, 5-triazine derivative and method of using same
PT3580208T (pt) Derivados de 2-(3-(1h-benzo[d]imidazol-1-il)propil)piperidin-3-ol e compostos relacionados como inibidores de prs para tratamento de, por exemplo, cancro
GB2577981B (en) Methods, products & Uses relating thereto
ZA201906848B (en) Novel pyrrolopyridine derivative, method for producing same, and use thereof
GB201813648D0 (en) Methods, products & uses relating thereto
IL284765A (en) 8,1-naphthyridinone compounds and their uses
SG11202008531RA (en) Oxazino-quinazoline and Oxazino-quinoline Type Compound, Preparation Method and Uses Thereof
ZA202401526B (en) 2-homopiperazine-1-yl-4h-1,3-benzothiazine-4-one derivatives and process for the preparation of 2- (homo)piperazine 1,3-benzothiazine-4-one hydrochlorides
IL282817A (en) New material, production method, and its use
GB202008327D0 (en) Method for preparing 2,2'dipyridine and derivatives thereof
EP3398943A4 (en) Method for producing 1,2,3,5,6-pentathiepane
EP3778553A4 (en) PROCESS FOR THE PREPARATION OF HEXAHYDROFURO-FURANOL DERIVATIVES, INTERMEDIATE THEREOF AND PREPARATION PROCESS THEREOF
EP3915977A4 (en) 1,2,3,4-TETRAHYDROCHINOXALINE DERIVATIVE, PROCESS FOR ITS PRODUCTION AND ITS USE
IL276125A (en) Dihydroindolizinone derivative compounds, preparations containing them and their uses
GB201912016D0 (en) Methods, products & uses relating thereto