PL3984590T3 - Wytwarzanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) o wysokiej równomierności w całym mózgu - Google Patents

Wytwarzanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) o wysokiej równomierności w całym mózgu

Info

Publication number
PL3984590T3
PL3984590T3 PL21205743.4T PL21205743T PL3984590T3 PL 3984590 T3 PL3984590 T3 PL 3984590T3 PL 21205743 T PL21205743 T PL 21205743T PL 3984590 T3 PL3984590 T3 PL 3984590T3
Authority
PL
Poland
Prior art keywords
ttfields
brain
high uniformity
uniformity throughout
tumor treating
Prior art date
Application number
PL21205743.4T
Other languages
English (en)
Inventor
Zeev Bomzon
Ariel NAEH
Ofir YESHARIM
Original Assignee
Novocure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novocure Gmbh filed Critical Novocure Gmbh
Publication of PL3984590T3 publication Critical patent/PL3984590T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/63—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Databases & Information Systems (AREA)
  • Urology & Nephrology (AREA)
  • General Business, Economics & Management (AREA)
  • Pathology (AREA)
  • Business, Economics & Management (AREA)
  • Data Mining & Analysis (AREA)
  • Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Developmental Disabilities (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Social Psychology (AREA)
  • Electrotherapy Devices (AREA)
PL21205743.4T 2018-10-15 2019-10-11 Wytwarzanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) o wysokiej równomierności w całym mózgu PL3984590T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862745689P 2018-10-15 2018-10-15

Publications (1)

Publication Number Publication Date
PL3984590T3 true PL3984590T3 (pl) 2023-05-02

Family

ID=68426548

Family Applications (1)

Application Number Title Priority Date Filing Date
PL21205743.4T PL3984590T3 (pl) 2018-10-15 2019-10-11 Wytwarzanie pól leczących guzy (pól elektrycznych do leczenia nowotworów ttfields) o wysokiej równomierności w całym mózgu

Country Status (7)

Country Link
US (4) US11241577B2 (pl)
EP (4) EP3984590B1 (pl)
JP (2) JP7284886B2 (pl)
CN (3) CN118925057A (pl)
HU (1) HUE061361T2 (pl)
PL (1) PL3984590T3 (pl)
WO (1) WO2020079554A1 (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180001075A1 (en) 2016-06-30 2018-01-04 Novocure Limited Arrays for Longitudinal Delivery of TTFields to a Body
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
EP3984590B1 (en) * 2018-10-15 2022-12-07 Novocure GmbH Generating tumor treating fields (ttfields) with high uniformity throughout the brain
JP7148722B2 (ja) 2018-10-25 2022-10-05 ゼーヴ・ボンゾン 被験者の脊椎構造体に対する交番電界（例えばＴＴＦｉｅｌｄ）の送達
WO2021111186A1 (en) 2019-12-02 2021-06-10 Novocure Gmbh Methods and apparatuses for optimizing transducer array placement
EP4075442A1 (en) 2019-12-31 2022-10-19 Novocure GmbH Methods, systems, and apparatuses for fast approximation of electric field distribution
ES2950234T3 (es) 2019-12-31 2023-10-06 Novocure Gmbh Matrices para administrar campos de tratamiento de tumores (camposTT) con elementos de electrodos y sensores de temperatura accesibles individualmente
WO2021136965A2 (en) 2019-12-31 2021-07-08 Novocure Gmbh Methods, systems, and apparatuses for image segmentation
EP4091665B1 (en) 2019-12-31 2024-10-30 Novocure GmbH High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels
US20210299440A1 (en) 2020-03-30 2021-09-30 Novocure Gmbh Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases
BR112022021484A2 (pt) 2020-04-24 2022-12-13 Novocure Gmbh Uso de campos elétricos alternados para aumentar a permeabilidade da barreira hematoencefálica
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
JP7777118B2 (ja) * 2020-09-25 2025-11-27 ノボキュア ゲーエムベーハー 過熱することなく電流を最大化するために腫瘍治療電場（ＴＴＦｉｅｌｄ）における個々の電極要素における金属化範囲を変化させること
US12268890B2 (en) * 2020-09-30 2025-04-08 Novocure Gmbh Methods and systems for transducer array placement and skin surface condition avoidance
US12194295B2 (en) * 2020-09-30 2025-01-14 Novocure Gmbh Method and apparatus for delivering tumor treating fields to a torso, and method for determining locations for transducers to deliver tumor treating fields
TWI830958B (zh) * 2020-10-16 2024-02-01 瑞士商諾沃庫勒有限責任公司 用於判定傳感器陣列在個體之身體上之最佳位置以及規劃電極元件集合在個體之身體上之定位的方法
US11869151B2 (en) * 2021-01-26 2024-01-09 Beth Israel Deaconess Medical Center Systems and methods for finite element analysis of tumor treating fields
EP4240470A1 (en) * 2021-02-17 2023-09-13 Novocure Gmbh Arrays for delivering tumor treating fields (ttfields) with sets of electrode elements having individually adjustable active areas
US12440680B2 (en) 2021-03-12 2025-10-14 Novocure Gmbh Methods of treating disease by skewing macrophage phenotype with alternating electric fields
EP4284489B1 (en) 2021-03-31 2025-07-16 Novocure Gmbh Impedance tomography using electrodes of a tumor treating fields (ttfields) system
US12377265B2 (en) * 2021-06-30 2025-08-05 Novocure Gmbh Nonconductive field guide for resection cavity, and systems and methods of using same
KR20240027008A (ko) 2021-06-30 2024-02-29 노보큐어 게엠베하 종양 치료 필드(ttfield)를 인가하기 위한 트랜스듀서 어레이에서 전류를 제한하기 위한 커패시터의 사용
WO2023053044A1 (en) * 2021-09-30 2023-04-06 Novocure Gmbh Reducing electrosensation whilst treating a subject using alternating electric fields
US12599765B2 (en) 2021-12-14 2026-04-14 Novocure Gmbh Shifting of transducer array to reduce skin irritation
EP4398973A1 (en) * 2021-12-14 2024-07-17 Novocure GmbH Transducer array with shape that contours to a subject's body and method of determining shape and placement of transducer arrays
WO2023126842A1 (en) 2021-12-29 2023-07-06 Novocure Gmbh Apparatus for reducing electrosensation using alternating electric fields with larger cathodes and smaller anodes
EP4456971A1 (en) 2021-12-30 2024-11-06 Novocure GmbH Selecting values of parameters for treatment using tumor treating fields (ttfields)
US12478793B2 (en) 2022-03-30 2025-11-25 Novocure Gmbh Reducing electrosensation whilst treating a subject using alternating electric fields by pairing transducer arrays together
EP4460361B1 (en) 2022-03-30 2025-03-19 Novocure GmbH Using interleaved cooling periods to increase the peak intensity of tumor treating fields
US12268863B2 (en) 2023-02-06 2025-04-08 Novocure Gmbh Shiftable transducer array with anisotropic material layer
JP7846835B2 (ja) * 2023-02-06 2026-04-15 ノボキュア ゲーエムベーハー 異方性材料層を備えた移行可能なトランスデューサアレイ
SE2350150A1 (en) * 2023-02-15 2024-08-16 Force Oncology Ab Tumor treating fields (ttfields) equipment configurations for improved ease-of-use
CN121925295A (zh) 2023-09-29 2026-04-24 诺沃库勒有限责任公司 使用振幅和频率的交错变化来改善用交变电场进行治疗期间的电感觉

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6081744A (en) 1993-05-28 2000-06-27 Loos; Hendricus G. Electric fringe field generator for manipulating nervous systems
US6366813B1 (en) 1998-08-05 2002-04-02 Dilorenzo Daniel J. Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7599745B2 (en) 2000-02-17 2009-10-06 Standen Ltd Treating a tumor or the like with an electric field
US7136699B2 (en) 2002-10-02 2006-11-14 Standen, Ltd. Apparatus for destroying dividing cells
US8447395B2 (en) * 2000-02-17 2013-05-21 Novocure Ltd Treating bacteria with electric fields
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
EP2335776A1 (en) 2000-02-17 2011-06-22 Yoram Palti Method and apparatus for destroying dividing cells
US7146210B2 (en) 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
US8175698B2 (en) 2000-02-17 2012-05-08 Novocure Ltd. Treating bacteria with electric fields
EP1331965B1 (en) 2000-10-26 2008-07-16 Medtronic, Inc. Apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac conditions
ES2344215T3 (es) 2004-12-07 2010-08-20 Standen Ltd. Electrodos para aplicar un campo electrico in vivo durante un dilatado periodo de tiempo.
JP5559460B2 (ja) 2004-12-27 2014-07-23 スタンデン・リミテッド 異なる配向の電界を用いて腫瘍またはその類似物を処理する方法
CA2624624C (en) 2005-10-03 2016-07-19 Novocure Limited Optimizing characteristics of an electric field to increase the field's effect on proliferating cells
US10537728B2 (en) * 2005-11-10 2020-01-21 ElectroCore, LLC Vagal nerve stimulation to avert or treat stroke or transient ischemic attack
US8019414B2 (en) 2006-04-05 2011-09-13 Novocure Ltd. Treating cancer using electromagnetic fields in combination with other treatment regimens
US7949403B2 (en) 2007-02-27 2011-05-24 Accelerated Care Plus Corp. Electrical stimulation device and method for the treatment of neurological disorders
WO2009044289A1 (en) 2007-03-06 2009-04-09 Novocure Ltd. Treating cancer using electromagnetic fields in combination with photodynamic therapy
CN101820947A (zh) 2007-08-14 2010-09-01 诺沃库勒有限公司 用电场治疗寄生物
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode
CA2765891A1 (en) 2008-06-18 2009-12-23 Accelerated Care Plus Corp. Electrical stimulation method for reduction of joint compression
US8968173B2 (en) * 2008-07-16 2015-03-03 Frank Sivo Methods to arrest cancer cell growth and proliferation using electromagnetic energy delivered via electromagnetic coil systems
US20170164878A1 (en) * 2012-06-14 2017-06-15 Medibotics Llc Wearable Technology for Non-Invasive Glucose Monitoring
US9180302B2 (en) 2012-08-31 2015-11-10 Greatbatch Ltd. Touch screen finger position indicator for a spinal cord stimulation programming device
EP2945691B1 (en) 2013-01-21 2019-03-06 Cala Health, Inc. Devices for controlling tremor
EP2983629B1 (en) 2013-04-10 2022-06-08 Zoll Circulation, Inc. Detecting and responding to preshivering
US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US9655669B2 (en) 2013-05-06 2017-05-23 Novocure Limited Optimizing treatment using TTFields by changing the frequency during the course of long term tumor treatment
US20140371566A1 (en) * 2013-06-14 2014-12-18 Cardiothrive, Inc. Conforming patient contact interface and method for using same
US10293161B2 (en) 2013-06-29 2019-05-21 Thync Global, Inc. Apparatuses and methods for transdermal electrical stimulation of nerves to modify or induce a cognitive state
US20150094557A1 (en) * 2013-09-30 2015-04-02 Mediatek Inc. Patches for bio-electrical signal processing
US9498635B2 (en) * 2013-10-16 2016-11-22 Syntilla Medical LLC Implantable head located radiofrequency coupled neurostimulation system for head pain
WO2015066303A1 (en) 2013-11-01 2015-05-07 Boston Scientific Neuromodulation Corporation Systems for delivering sub-threshold therapy at a midline
US20150224318A1 (en) 2014-02-12 2015-08-13 Pacesetter, Inc. Methods and systems for neurostimulation using paddle lead
CN106794347B (zh) 2014-05-23 2020-01-17 电核有限责任公司 用于迷走神经刺激的系统和方法
KR20170063440A (ko) 2014-05-25 2017-06-08 하이인 에쿼티 인베스트먼트 펀드 엘.피. 웨어러블 경피 신경자극기들
WO2016157183A1 (en) 2015-03-30 2016-10-06 Enopace Biomedical Ltd. Antenna for use with an intravascular device
US9910453B2 (en) 2015-09-25 2018-03-06 Novocure Limited High voltage, high efficiency sine wave generator with pre-set frequency and adjustable amplitude
US10188851B2 (en) * 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US9956405B2 (en) 2015-12-18 2018-05-01 Thyne Global, Inc. Transdermal electrical stimulation at the neck to induce neuromodulation
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
US10646708B2 (en) 2016-05-20 2020-05-12 Thync Global, Inc. Transdermal electrical stimulation at the neck
US20180001075A1 (en) 2016-06-30 2018-01-04 Novocure Limited Arrays for Longitudinal Delivery of TTFields to a Body
US20180008708A1 (en) 2016-07-10 2018-01-11 Novocure Limited Synchronizing Tumor Cells to the G2/M Phase Using TTFields Combined with Taxane or Other Anti-Microtubule Agents
CN116747440A (zh) 2016-08-18 2023-09-15 诺沃库勒有限责任公司 用于递送肿瘤治疗电场的阵列中的温度测量
WO2018057953A2 (en) * 2016-09-23 2018-03-29 Beth Isreal Deaconess Medical Center, Inc. System and methods for cancer treatment using alternating electric fields
DK3554631T3 (da) * 2016-12-13 2022-05-30 Novocure Gmbh Behandling af patienter med ttfields med elektrodepositionerne optimeret under anvendelse af deformerbare skabeloner
WO2018134733A1 (en) 2017-01-19 2018-07-26 Moshe Giladi System for viewing cell cultures under a microscope whilst applying ttfields
PL421532A1 (pl) * 2017-05-08 2018-11-19 Michalczyk Marta System do leczenia nowotworów wewnątrzczaszkowych z wykorzystaniem implantu, generującego ciągłe, zmienne pole elektryczne oraz ultradźwięki, zasilanego metodą przezskórnego transferu energii
WO2018217577A1 (en) * 2017-05-22 2018-11-29 Thync Global, Inc. Systems and methods for applying electrical energy to treat medical disorders
CN112543661A (zh) 2017-11-17 2021-03-23 艾伯维公司 治疗胶质母细胞瘤的方法
US10953209B2 (en) 2018-03-28 2021-03-23 Board Of Regents Of The University Of Texas System Treating tumors using TTFields combined with a PARP inhibitor
EP3773726B1 (en) 2018-04-09 2024-06-05 Novocure GmbH Treating tumors with ttfields and an aurora kinase inhibitor
EP3775956B1 (en) 2018-04-10 2022-03-23 Novocure GmbH Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times
ES3047748T3 (en) 2018-07-03 2025-12-04 Univ Leland Stanford Junior Using alternating electric fields to increase cell membrane permeability
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
KR102794415B1 (ko) 2018-07-10 2025-04-09 노보큐어 게엠베하 교류 전기장을 사용한 바이러스 감염 억제
MX2020013431A (es) 2018-07-18 2021-05-27 Novocure Gmbh Uso de densidad de perdida de potencia y mediciones relacionadas para cuantificar la dosis de campos de tratamiento de tumores (ttfield).
EP3878389B1 (en) 2018-08-23 2025-08-06 Novocure GmbH Using alternating electric fields to increase permeability of the blood brain barrier
US11160977B2 (en) * 2018-09-04 2021-11-02 Novocure Gmbh Delivering tumor treating fields (TTFields) to the infratentorial brain
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
WO2020049482A1 (en) 2018-09-07 2020-03-12 Yaniv Alon Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
US20200108031A1 (en) 2018-10-05 2020-04-09 Novocure Gmbh Treating Tumors Using TTFields Combined with ABT-751
EP3984590B1 (en) * 2018-10-15 2022-12-07 Novocure GmbH Generating tumor treating fields (ttfields) with high uniformity throughout the brain
CN113164525B (zh) 2018-10-23 2025-03-14 利兰·斯坦福青年大学托管委员会 在基于干细胞的疗法中使用交变电场预防和治疗畸胎瘤形成
JP7148722B2 (ja) 2018-10-25 2022-10-05 ゼーヴ・ボンゾン 被験者の脊椎構造体に対する交番電界（例えばＴＴＦｉｅｌｄ）の送達
US20200146586A1 (en) 2018-11-14 2020-05-14 Novocure Gmbh Creating Accurate Computational Head Models of Patients Using Datasets Combining MRI and CT Images
IL280843B2 (en) 2018-11-19 2025-10-01 Novocure Gmbh Arrays for providing fields treat growth with selectively addressable sub-elements
EP3961565A1 (en) 2019-01-08 2022-03-02 Novocure GmbH Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields)
CN113613651B (zh) 2019-03-29 2025-08-12 诺沃库勒有限责任公司 用PTGER3抑制剂恢复TTField抗性癌细胞中对TTField的敏感性的方法
US11291837B2 (en) 2019-04-17 2022-04-05 Novocure Gmbh Uploading data from an isolated system without compromising isolation
USD934892S1 (en) 2019-05-03 2021-11-02 Novocure Gmbh Display screen or portion thereof with a graphical user interface
US11654279B2 (en) 2019-07-31 2023-05-23 Novocure Gmbh Applying tumor treating fields (TTFields) via electrodes embedded into skull implants
WO2021024170A1 (en) 2019-08-05 2021-02-11 Voloshin Sela Tali Increasing cancer cells' sensitivity to tumor treating fields (ttfields) by inhibiting il11 activity
US11890467B2 (en) 2019-08-30 2024-02-06 Novocure Gmbh Delivering tumor treating fields (TTFields) to the neck
WO2021050093A1 (en) 2019-09-10 2021-03-18 Novocure Gmbh A method of reducing viability of cancer cells by applying alternating electric fields and administering checkpoint inhibitors to the cancer cells
JP7687698B2 (ja) 2019-12-26 2025-06-03 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 癌細胞における異常な解糖的代謝を正常化する方法
ES2950234T3 (es) 2019-12-31 2023-10-06 Novocure Gmbh Matrices para administrar campos de tratamiento de tumores (camposTT) con elementos de electrodos y sensores de temperatura accesibles individualmente
EP4091665B1 (en) 2019-12-31 2024-10-30 Novocure GmbH High voltage, high efficiency sine wave generator that prevents spikes during amplitude adjustments and switching of channels
US20210299440A1 (en) 2020-03-30 2021-09-30 Novocure Gmbh Intravenous / Intra-Spinal / Intra-Cavity / Intraventricular Delivery of TTFields (Tumor Treating Fields) for Treating Cancer and Metastases
BR112022021484A2 (pt) 2020-04-24 2022-12-13 Novocure Gmbh Uso de campos elétricos alternados para aumentar a permeabilidade da barreira hematoencefálica

Also Published As

Publication number Publication date
CN118925057A (zh) 2024-11-12
JP7284886B2 (ja) 2023-06-01
US11154707B2 (en) 2021-10-26
JP7536934B2 (ja) 2024-08-20
CN112930209A (zh) 2021-06-08
EP4137195C0 (en) 2024-12-11
US20220118249A1 (en) 2022-04-21
EP3984590A1 (en) 2022-04-20
US20200114142A1 (en) 2020-04-16
CN118925056A (zh) 2024-11-12
HUE061361T2 (hu) 2023-06-28
JP2023083291A (ja) 2023-06-15
JP2022512690A (ja) 2022-02-07
EP4137195A1 (en) 2023-02-22
EP3984590B1 (en) 2022-12-07
US20200114141A1 (en) 2020-04-16
EP3878505B1 (en) 2023-05-24
WO2020079554A1 (en) 2020-04-23
EP3840823C0 (en) 2023-07-12
US12208275B2 (en) 2025-01-28
EP3840823B1 (en) 2023-07-12
US20240082592A1 (en) 2024-03-14
US11241577B2 (en) 2022-02-08
EP4137195B1 (en) 2024-12-11
US11865355B2 (en) 2024-01-09
EP3878505A1 (en) 2021-09-15
CN112930209B (zh) 2024-10-15
EP3840823A1 (en) 2021-06-30

Similar Documents

Publication Publication Date Title
HUE061361T2 (hu) Az egész agyban nagy egyenletességû tumorkezelõ mezõk (TT-mezõk) generálása
IL280844A (en) Transducer arrays with improved flexibility to provide tumor treating fields
IL280843A (en) Arrays for administration of fields treat the tumor with sub-elements administered selectively
IL291844B1 (en) smc combined therapy for cancer treatment
ZA201905902B (en) 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer
ZA202004913B (en) Improved microbes and methods for producing the same
GB201719076D0 (en) Particles for the treatment of cancer in combination with radiotherapy
HUE048646T2 (hu) Ráksejtek motilitásának csökkentése tumorkezelõ mezõket (TTFields) alkalmazva
EP3832003A4 (en) GARMENT TREATMENT APPARATUS
GB201804255D0 (en) Macrophage-based therapy
ZA202203776B (en) Methods of treating epilepsy using the same
PL3579826T3 (pl) Sposoby leczenia zaburzeń cdkl5 związkiem ov329
MX2022007955A (es) Regimenes de dosificacion de erdafitinib.
PH12018501455A1 (en) Therapeutic compostions and methods for treating hepatitis b
IL277739A (en) Radiotherapy process and system
GB2575637B (en) Radiotherapy apparatus
GB201707503D0 (en) New Therapy 3
GB201707501D0 (en) New therapy 2
ZA202101493B (en) Hair treatment process
SMT202100138T1 (it) Derivato di 5-metil-6-fenil-4,5-diidr0-2h-piridazin-3-0ne per il trattamento di tumori cerebrali
EP3674398A4 (en) ECHOVIRUS FOR TUMOR TREATMENT
IL282181A (en) Kir 7.1 Vectors for gene therapy and methods of use
KR102167683B9 (ko) 고주파 심부열 발생장치
IL269681A (en) New methods for treating multiple sclerosis
GB201819920D0 (en) Cancer treatment