PL362870A1 - Zmodyfikowany interferon beta o obniżonej immunogeniczności - Google Patents

Zmodyfikowany interferon beta o obniżonej immunogeniczności

Info

Publication number
PL362870A1
PL362870A1 PL02362870A PL36287002A PL362870A1 PL 362870 A1 PL362870 A1 PL 362870A1 PL 02362870 A PL02362870 A PL 02362870A PL 36287002 A PL36287002 A PL 36287002A PL 362870 A1 PL362870 A1 PL 362870A1
Authority
PL
Poland
Prior art keywords
interferon beta
reduced immunogenicity
modified interferon
modified
immunogenicity
Prior art date
Application number
PL02362870A
Other languages
English (en)
Inventor
Francis J. Carr
Graham Carter
Tim Jones
John Watkins
Matthew Baker
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL362870A1 publication Critical patent/PL362870A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL02362870A 2001-03-15 2002-03-15 Zmodyfikowany interferon beta o obniżonej immunogeniczności PL362870A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01106539 2001-03-15
PCT/EP2002/002925 WO2002074783A2 (en) 2001-03-15 2002-03-15 Modified interferon beta with reduced immunogenicity

Publications (1)

Publication Number Publication Date
PL362870A1 true PL362870A1 (pl) 2004-11-02

Family

ID=8176796

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02362870A PL362870A1 (pl) 2001-03-15 2002-03-15 Zmodyfikowany interferon beta o obniżonej immunogeniczności

Country Status (13)

Country Link
US (2) US7381795B2 (pl)
EP (1) EP1368377A2 (pl)
JP (1) JP2004529633A (pl)
KR (1) KR20030084992A (pl)
CN (1) CN1496369A (pl)
BR (1) BR0208041A (pl)
CA (1) CA2441095A1 (pl)
HU (1) HUP0303534A3 (pl)
MX (1) MXPA03008310A (pl)
PL (1) PL362870A1 (pl)
RU (1) RU2003129072A (pl)
WO (1) WO2002074783A2 (pl)
ZA (1) ZA200307992B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1368377A2 (en) * 2001-03-15 2003-12-10 MERCK PATENT GmbH Modified interferon beta with reduced immunogenicity
AU2003224650A1 (en) * 2002-03-02 2003-09-16 University Of South Florida A method for treating allergic disease and asthma by recombinant adenovirus-and adeno-associated virus-mediated ifn-gamma gene
US7354908B2 (en) 2002-04-30 2008-04-08 University Of South Florida Materials and methods for prevention and treatment of RNA viral diseases
DK1578772T3 (da) * 2002-05-01 2010-08-16 Danisco Us Inc Cytokiner og cytokinreceptorer med reduceret immunogenicitet
US7595303B1 (en) * 2002-09-05 2009-09-29 University Of South Florida Genetic adjuvants for immunotherapy
CA2498319A1 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
WO2004074314A2 (en) * 2003-02-14 2004-09-02 University Of South Florida Chistosan-microparticles for ifn gene delivery
EP1636256A2 (en) * 2003-06-10 2006-03-22 Xencor, Inc. Interferon variants with improved properties
US20050266093A1 (en) * 2004-04-27 2005-12-01 Mohapatra Shyam S Nanogene therapy for cell proliferation disorders
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
WO2007110231A2 (en) * 2006-03-28 2007-10-04 Nautilus Biotech, S.A. MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES
KR101722305B1 (ko) 2007-01-30 2017-03-31 에피백스, 인크. 조절 ｔ 세포 에피토프, 그의 조성물 및 용도
WO2008137471A2 (en) 2007-05-02 2008-11-13 Ambrx, Inc. Modified interferon beta polypeptides and their uses
CA2691539C (en) * 2007-06-21 2014-08-26 Angelica Therapeutics, Inc. Modified toxins
WO2009110944A1 (en) * 2008-02-29 2009-09-11 Angelica Therapeutics, Inc. Modified toxins
EP2421896A1 (en) 2009-04-22 2012-02-29 Merck Patent GmbH Antibody fusion proteins with modified fcrn binding sites
CN109134642A (zh) 2011-10-01 2019-01-04 株式会社糖锁工学研究所 加成糖链的多肽及含有该多肽的医药组合物
CA2902905A1 (en) 2013-03-15 2014-09-25 Claude Geoffrey Davis Modified toxins
ES2687801T3 (es) 2013-03-29 2018-10-29 Glytech, Inc. Polipéptido presentando cadenas de azúcares sialiladas unidas al mismo

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
DE69833755T2 (de) * 1997-05-21 2006-12-28 Biovation Ltd. Verfahren zur herstellung von nicht-immunogenen proteinen
BR9915548A (pt) * 1998-10-16 2001-08-14 Biogen Inc Proteìnas de fusão de interferon-beta e usos
JP2002534959A (ja) * 1998-12-08 2002-10-22 バイオベーション リミテッド 免疫原性タンパク質の改変方法
US6514729B1 (en) * 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
US6531122B1 (en) * 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
EP1368377A2 (en) * 2001-03-15 2003-12-10 MERCK PATENT GmbH Modified interferon beta with reduced immunogenicity

Also Published As

Publication number Publication date
RU2003129072A (ru) 2005-04-20
ZA200307992B (en) 2005-01-14
JP2004529633A (ja) 2004-09-30
US20050054052A1 (en) 2005-03-10
US7615615B2 (en) 2009-11-10
WO2002074783A2 (en) 2002-09-26
CN1496369A (zh) 2004-05-12
BR0208041A (pt) 2004-02-25
US20090043076A1 (en) 2009-02-12
US7381795B2 (en) 2008-06-03
EP1368377A2 (en) 2003-12-10
HUP0303534A3 (en) 2005-12-28
CA2441095A1 (en) 2002-09-26
MXPA03008310A (es) 2003-12-11
HUP0303534A2 (hu) 2004-01-28
KR20030084992A (ko) 2003-11-01
WO2002074783A3 (en) 2003-08-28

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Legal Events

Date Code Title Description
DISC Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)