PL358057A1 - Związki skuteczne jako związki agonistyczne receptora adrenergicznego-beta2 jak i inhibitory PDE-4 - Google Patents
Związki skuteczne jako związki agonistyczne receptora adrenergicznego-beta2 jak i inhibitory PDE-4Info
- Publication number
- PL358057A1 PL358057A1 PL01358057A PL35805701A PL358057A1 PL 358057 A1 PL358057 A1 PL 358057A1 PL 01358057 A PL01358057 A PL 01358057A PL 35805701 A PL35805701 A PL 35805701A PL 358057 A1 PL358057 A1 PL 358057A1
- Authority
- PL
- Poland
- Prior art keywords
- pde4
- inhibitors
- beta
- well
- compounds effective
- Prior art date
Links
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 title 1
- 101710152983 Beta-2 adrenergic receptor Proteins 0.000 title 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00111795 | 2000-06-05 | ||
| PCT/EP2001/006230 WO2001094319A1 (en) | 2000-06-05 | 2001-06-01 | Compounds effective as beta-2-adrenoreceptor agonists as well as pde4-inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL358057A1 true PL358057A1 (pl) | 2004-08-09 |
Family
ID=8168897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL01358057A PL358057A1 (pl) | 2000-06-05 | 2001-06-01 | Związki skuteczne jako związki agonistyczne receptora adrenergicznego-beta2 jak i inhibitory PDE-4 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6933296B2 (pl) |
| EP (1) | EP1296956A1 (pl) |
| JP (1) | JP2003535850A (pl) |
| KR (1) | KR20030031907A (pl) |
| CN (1) | CN1471515A (pl) |
| AU (2) | AU2001262332B2 (pl) |
| BR (1) | BR0111440A (pl) |
| CA (1) | CA2411351A1 (pl) |
| CZ (1) | CZ20023997A3 (pl) |
| EA (1) | EA005824B1 (pl) |
| HK (1) | HK1052346A1 (pl) |
| HU (1) | HUP0301240A3 (pl) |
| IL (1) | IL152846A0 (pl) |
| MX (1) | MXPA02012042A (pl) |
| NO (1) | NO20025811L (pl) |
| NZ (1) | NZ522882A (pl) |
| PL (1) | PL358057A1 (pl) |
| SK (1) | SK17052002A3 (pl) |
| WO (1) | WO2001094319A1 (pl) |
| ZA (1) | ZA200209598B (pl) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20030636B1 (en) | 2001-02-15 | 2012-05-31 | Nycomed Gmbh | Phthalayinone-piperidino-derivatives as pde4 inhibitors |
| PL363544A1 (pl) | 2001-04-25 | 2004-11-29 | Altana Pharma Ag | Nowe pochodne piperazynowe |
| EA200301100A1 (ru) | 2001-04-25 | 2004-06-24 | Алтана Фарма Аг | Новые фталазиноны |
| ES2195785B1 (es) | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| JP2005538138A (ja) * | 2002-08-10 | 2005-12-15 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ４インヒビターとしてのピリダジノン誘導体 |
| WO2004018457A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Pyrrolidinedione substituted piperidine-phthalazones as pde4 inhibitors |
| AU2003260371A1 (en) * | 2002-08-10 | 2004-03-11 | Altana Pharma Ag | Piperidine-n-oxide-derivatives |
| JP2006513222A (ja) * | 2002-12-23 | 2006-04-20 | アルテシアン セラピューティック，インコーポレイティド | アドレナリン性β受容体およびホスホジエステラーゼに対する抑制活性を有する強心性化合物 |
| ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| ES2232306B1 (es) | 2003-11-10 | 2006-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| EP1716133B1 (en) * | 2004-02-04 | 2008-03-26 | Nycomed GmbH | 2-(piperidin-4-yl)-4,5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors |
| WO2005075437A1 (en) * | 2004-02-04 | 2005-08-18 | Altana Pharma Ag | Pyridazinone derivatives and their use as pde4 inhibitors |
| ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| US20070225217A1 (en) | 2005-11-09 | 2007-09-27 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| GB0805535D0 (en) | 2008-03-27 | 2008-04-30 | Univ Leicester | Scar prevention |
| US8969348B2 (en) | 2008-08-13 | 2015-03-03 | Boehringer Ingelheim International Gmbh | Chymase inhibitors |
| NZ603136A (en) * | 2010-05-10 | 2014-11-28 | Gilead Sciences Inc | Bifunctional quinoline derivatives |
| AR081377A1 (es) | 2010-05-10 | 2012-08-29 | Gilead Sciences Inc | Compuestos de pirazolopiridina bifuncionales |
| US20140112945A1 (en) * | 2011-06-17 | 2014-04-24 | Takeda Gmbh | Novel phthalazinone-pyrrolopyrimidinecarboxamide derivatives |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| GB2513297A (en) | 2013-03-08 | 2014-10-29 | Univ Leicester | Methods |
| KR102885525B1 (ko) | 2018-11-06 | 2025-11-13 | 엣지와이즈 테라퓨틱스, 인크. | 피리다지논 화합물 및 이의 용도 |
| WO2020097258A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| KR20210100094A (ko) | 2018-11-06 | 2021-08-13 | 엣지와이즈 테라퓨틱스, 인크. | 피리다지논 화합물 및 이의 용도 |
| EP4149621B1 (en) * | 2020-05-13 | 2024-10-30 | Edgewise Therapeutics, Inc. | Pyridazinone compounds for the treatment of neuromuscular diseases |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030835B1 (en) * | 1979-12-05 | 1983-05-11 | Morishita Pharmaceutical Co. Ltd. | Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them |
| JPS58146571A (ja) * | 1982-02-25 | 1983-09-01 | Morishita Seiyaku Kk | ウレア誘導体およびその製造法 |
| PL164079B1 (pl) * | 1990-06-15 | 1994-06-30 | Akad Medyczna | posób wytwarzania nowych 2-amlnoalkilopochodnych 5-aminometyleno-6-/p-chlorofenylo /-4,5-dihydro-2H- plrydazyn -3-onu |
| ATE234270T1 (de) | 1992-12-02 | 2003-03-15 | Pfizer | Cathecoldiether als selektive pde iv hemmungsmittel |
| DE19533975A1 (de) | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
| KR20000070150A (ko) | 1997-01-15 | 2000-11-25 | 빅 굴덴 롬베르크 케미쉐 파브릭 게엠베하 | 프탈라지논 |
| SI0975347T1 (sl) | 1997-02-28 | 2008-08-31 | Nycomed Gmbh | Sinergistična kombinacija PDE inhibitorjev in agonistov adenilat ciklaze oziroma agonistov gvanil ciklize |
| WO1999031071A1 (en) * | 1997-12-15 | 1999-06-24 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New phthalazinones |
| DE69821530T2 (de) * | 1997-12-15 | 2004-12-23 | Altana Pharma Ag | Dihydrobenzifurane |
| EP0934933A1 (en) * | 1998-02-06 | 1999-08-11 | Byk Gulden Lomberg Chemische Fabrik GmbH | Phthalazinones |
| HUP0103160A3 (en) | 1998-08-26 | 2002-11-28 | Smithkline Beecham Corp | Pharmaceutical compositions for treating pulmonary diseases containing pde4 inhibitor |
-
2001
- 2001-06-01 BR BR0111440-9A patent/BR0111440A/pt not_active IP Right Cessation
- 2001-06-01 NZ NZ522882A patent/NZ522882A/en unknown
- 2001-06-01 HU HU0301240A patent/HUP0301240A3/hu unknown
- 2001-06-01 CZ CZ20023997A patent/CZ20023997A3/cs unknown
- 2001-06-01 HK HK03104534.2A patent/HK1052346A1/zh unknown
- 2001-06-01 AU AU2001262332A patent/AU2001262332B2/en not_active Ceased
- 2001-06-01 EP EP01936419A patent/EP1296956A1/en not_active Withdrawn
- 2001-06-01 CN CNA018106870A patent/CN1471515A/zh active Pending
- 2001-06-01 CA CA002411351A patent/CA2411351A1/en not_active Abandoned
- 2001-06-01 IL IL15284601A patent/IL152846A0/xx unknown
- 2001-06-01 KR KR1020027016611A patent/KR20030031907A/ko not_active Withdrawn
- 2001-06-01 WO PCT/EP2001/006230 patent/WO2001094319A1/en not_active Ceased
- 2001-06-01 EA EA200201252A patent/EA005824B1/ru not_active IP Right Cessation
- 2001-06-01 MX MXPA02012042A patent/MXPA02012042A/es unknown
- 2001-06-01 US US10/296,411 patent/US6933296B2/en not_active Expired - Fee Related
- 2001-06-01 JP JP2002501869A patent/JP2003535850A/ja active Pending
- 2001-06-01 AU AU6233201A patent/AU6233201A/xx active Pending
- 2001-06-01 SK SK1705-2002A patent/SK17052002A3/sk not_active Application Discontinuation
- 2001-06-01 PL PL01358057A patent/PL358057A1/pl not_active Application Discontinuation
-
2002
- 2002-11-26 ZA ZA200209598A patent/ZA200209598B/en unknown
- 2002-12-03 NO NO20025811A patent/NO20025811L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02012042A (es) | 2004-08-19 |
| NZ522882A (en) | 2004-07-30 |
| SK17052002A3 (sk) | 2003-12-02 |
| EP1296956A1 (en) | 2003-04-02 |
| IL152846A0 (en) | 2003-06-24 |
| AU6233201A (en) | 2001-12-17 |
| EA005824B1 (ru) | 2005-06-30 |
| WO2001094319A1 (en) | 2001-12-13 |
| HUP0301240A3 (en) | 2004-03-29 |
| US6933296B2 (en) | 2005-08-23 |
| AU2001262332B2 (en) | 2006-05-25 |
| US20030195215A1 (en) | 2003-10-16 |
| NO20025811D0 (no) | 2002-12-03 |
| ZA200209598B (en) | 2003-07-29 |
| CZ20023997A3 (cs) | 2003-05-14 |
| HUP0301240A2 (hu) | 2003-12-29 |
| NO20025811L (no) | 2003-02-04 |
| JP2003535850A (ja) | 2003-12-02 |
| EA200201252A1 (ru) | 2003-06-26 |
| KR20030031907A (ko) | 2003-04-23 |
| BR0111440A (pt) | 2003-06-03 |
| HK1052346A1 (zh) | 2003-09-11 |
| CA2411351A1 (en) | 2001-12-13 |
| CN1471515A (zh) | 2004-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |