PL3429993T3 - Selektywni antagoniści/częściowi agoniści receptora dopaminowego d3, sposób ich otrzymywania i zastosowania - Google Patents
Selektywni antagoniści/częściowi agoniści receptora dopaminowego d3, sposób ich otrzymywania i zastosowaniaInfo
- Publication number
- PL3429993T3 PL3429993T3 PL17711971T PL17711971T PL3429993T3 PL 3429993 T3 PL3429993 T3 PL 3429993T3 PL 17711971 T PL17711971 T PL 17711971T PL 17711971 T PL17711971 T PL 17711971T PL 3429993 T3 PL3429993 T3 PL 3429993T3
- Authority
- PL
- Poland
- Prior art keywords
- dopamine
- recipe
- obtaining
- application
- partial agonists
- Prior art date
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 2
- 239000005557 antagonist Substances 0.000 title 1
- 229960003638 dopamine Drugs 0.000 title 1
- 239000004031 partial agonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662307600P | 2016-03-14 | 2016-03-14 | |
| PCT/US2017/021328 WO2017160552A1 (en) | 2016-03-14 | 2017-03-08 | Dopamine d3 receptor selective antagonists/partial agonists; method of making; and use thereof |
| EP17711971.6A EP3429993B1 (en) | 2016-03-14 | 2017-03-08 | Dopamine d3 receptor selective antagonists/partial agonists; method of making; and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3429993T3 true PL3429993T3 (pl) | 2021-11-15 |
Family
ID=58358971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17711971T PL3429993T3 (pl) | 2016-03-14 | 2017-03-08 | Selektywni antagoniści/częściowi agoniści receptora dopaminowego d3, sposób ich otrzymywania i zastosowania |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12162861B2 (pl) |
| EP (2) | EP3848351B1 (pl) |
| AU (1) | AU2017233716B2 (pl) |
| CA (1) | CA3017342A1 (pl) |
| DK (1) | DK3429993T3 (pl) |
| ES (1) | ES2881267T3 (pl) |
| HR (1) | HRP20211182T1 (pl) |
| HU (1) | HUE055634T2 (pl) |
| PL (1) | PL3429993T3 (pl) |
| PT (1) | PT3429993T (pl) |
| RS (1) | RS62156B1 (pl) |
| SI (1) | SI3429993T1 (pl) |
| WO (1) | WO2017160552A1 (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019340675B2 (en) * | 2018-09-11 | 2024-06-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine D3 receptor selective antagonists/partial agonists and uses thereof |
| WO2023014768A1 (en) * | 2021-08-03 | 2023-02-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | D3 dopamine receptor-selective negative allosteric modulators |
| CN114409621B (zh) * | 2022-02-09 | 2023-09-08 | 江苏省原子医学研究所 | 一种靶向多巴胺d3受体的诊疗药物及其应用 |
| EP4499619A1 (en) * | 2022-03-30 | 2025-02-05 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Synthesis of dopamine d3 receptor selective antagonists/partial agonists |
| WO2025006982A1 (en) * | 2023-06-30 | 2025-01-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Potent and selective dopamine d3 receptor antagonists |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5710274A (en) | 1996-02-28 | 1998-01-20 | Neurogen Corporation | N-aminoalkyldibenzofurancarboxamides; new dopamine receptor subtype specific ligands |
| US5763609A (en) | 1996-03-21 | 1998-06-09 | Neurogen Corporation | Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands |
| US5892041A (en) | 1996-08-12 | 1999-04-06 | Neurogen Corporation | Fused indolecarboxamides: dopamine receptor subtype specific ligands |
| HUP0103987A3 (en) * | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
| JP2005538974A (ja) | 2002-07-04 | 2005-12-22 | シュバルツ ファルマ アクチェンゲゼルシャフト | 中枢神経系の病気を治療するドーパミン−ｄ３リガンドとして使用するためのヘテロアレーンカルボキサミド |
| AU2003267201B2 (en) | 2002-09-14 | 2009-04-23 | The Gov't Of The U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services | Structurally rigid dopamine D3 receptor selective ligands and process for making them |
| JP2008508337A (ja) | 2004-08-02 | 2008-03-21 | シュバルツ ファルマ アクチェンゲゼルシャフト | インドリジンカルボキサミド並びにそのアザ及びジアザ誘導体 |
| DE102004054634A1 (de) | 2004-11-12 | 2006-05-18 | Schwarz Pharma Ag | Azaindolcarboxamide |
| US20090238761A1 (en) | 2005-01-03 | 2009-09-24 | Universita Degli Studi Di Siena | Novel Aryl Piperazine Derivatives With Medical Utility |
| FR2903986A1 (fr) | 2006-07-21 | 2008-01-25 | Pierre Fabre Medicament Sa | Nouveaux derives chromenes ou thiochromenes carboxamides, leur procede de preparation et leurs applications en therapeutique |
| AU2007354861B2 (en) | 2007-06-15 | 2013-03-21 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | 4-phenylpiperazine derivatives with functionalized linkers as dopamine D3 receptor selective ligands and methods of use |
| WO2014059265A1 (en) * | 2012-10-11 | 2014-04-17 | Southern Research Institute | Urea and amide derivatives of aminoalkylpiperazines and use thereof |
| AU2019340675B2 (en) | 2018-09-11 | 2024-06-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dopamine D3 receptor selective antagonists/partial agonists and uses thereof |
-
2017
- 2017-03-08 WO PCT/US2017/021328 patent/WO2017160552A1/en not_active Ceased
- 2017-03-08 HR HRP20211182TT patent/HRP20211182T1/hr unknown
- 2017-03-08 CA CA3017342A patent/CA3017342A1/en active Pending
- 2017-03-08 SI SI201730863T patent/SI3429993T1/sl unknown
- 2017-03-08 HU HUE17711971A patent/HUE055634T2/hu unknown
- 2017-03-08 PL PL17711971T patent/PL3429993T3/pl unknown
- 2017-03-08 RS RS20210938A patent/RS62156B1/sr unknown
- 2017-03-08 EP EP21158632.6A patent/EP3848351B1/en active Active
- 2017-03-08 EP EP17711971.6A patent/EP3429993B1/en active Active
- 2017-03-08 ES ES17711971T patent/ES2881267T3/es active Active
- 2017-03-08 DK DK17711971.6T patent/DK3429993T3/da active
- 2017-03-08 PT PT177119716T patent/PT3429993T/pt unknown
- 2017-03-08 AU AU2017233716A patent/AU2017233716B2/en active Active
-
2022
- 2022-03-03 US US17/685,709 patent/US12162861B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US12162861B2 (en) | 2024-12-10 |
| WO2017160552A1 (en) | 2017-09-21 |
| AU2017233716A1 (en) | 2018-10-04 |
| DK3429993T3 (da) | 2021-08-09 |
| EP3848351A1 (en) | 2021-07-14 |
| ES2881267T3 (es) | 2021-11-29 |
| EP3848351B1 (en) | 2025-01-15 |
| PT3429993T (pt) | 2021-07-19 |
| RS62156B1 (sr) | 2021-08-31 |
| HRP20211182T1 (hr) | 2021-10-15 |
| AU2017233716B2 (en) | 2020-10-29 |
| EP3429993B1 (en) | 2021-05-26 |
| CA3017342A1 (en) | 2017-09-21 |
| EP3429993A1 (en) | 2019-01-23 |
| HUE055634T2 (hu) | 2021-12-28 |
| US20220185798A1 (en) | 2022-06-16 |
| SI3429993T1 (sl) | 2021-09-30 |
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