PL340784A1 - Novel bicyclic compounds of amino pyrazinone, method of obtaining them and pharmacological compositions containing such compounds - Google Patents

Novel bicyclic compounds of amino pyrazinone, method of obtaining them and pharmacological compositions containing such compounds

Info

Publication number
PL340784A1
PL340784A1 PL00340784A PL34078400A PL340784A1 PL 340784 A1 PL340784 A1 PL 340784A1 PL 00340784 A PL00340784 A PL 00340784A PL 34078400 A PL34078400 A PL 34078400A PL 340784 A1 PL340784 A1 PL 340784A1
Authority
PL
Poland
Prior art keywords
compounds
pyrazinone
amino
obtaining
compositions containing
Prior art date
Application number
PL00340784A
Other versions
PL199522B1 (en
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of PL340784A1 publication Critical patent/PL340784A1/en
Publication of PL199522B1 publication Critical patent/PL199522B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A compound selected from those of formula (I):wherein:R1 represents hydrogen, optionally substituted alkyl, cycloalkyl or heterocycloalkyl or a group of formula (G):wherein A1 represents single, -CH2-, -CH2-CH2- or -N(CH3)- or oxygen or sulphur, and X1 and X2, which may be identical or different, each represent carbon or nitrogen,R represents hydrogen or linear or branched (C1-C6)alkyl, represents a saturated ring having from 4 to 7 ring members,n represents integer wherein 1<=n<=6,Ar represents aryl or heteroaryl,its isomers, N-oxydes and pharmaceutically-acceptable acid or base addition salts thereof.
PL340784A 1999-06-15 2000-06-15 Novel bicyclic compounds of amino pyrazinone, method of obtaining them and pharmacological compositions containing such compounds PL199522B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9907538A FR2795072B1 (en) 1999-06-15 1999-06-15 NOVEL BICYCLIC DERIVATIVES OF AMINO-PYRAZINONES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
PL340784A1 true PL340784A1 (en) 2000-12-18
PL199522B1 PL199522B1 (en) 2008-09-30

Family

ID=9546789

Family Applications (1)

Application Number Title Priority Date Filing Date
PL340784A PL199522B1 (en) 1999-06-15 2000-06-15 Novel bicyclic compounds of amino pyrazinone, method of obtaining them and pharmacological compositions containing such compounds

Country Status (23)

Country Link
US (1) US6277851B1 (en)
EP (1) EP1069132B1 (en)
JP (1) JP3364472B2 (en)
KR (1) KR100456796B1 (en)
CN (1) CN1147489C (en)
AT (1) ATE251177T1 (en)
AU (1) AU766194B2 (en)
BR (1) BR0002643A (en)
CA (1) CA2312206C (en)
DE (1) DE60005609T2 (en)
DK (1) DK1069132T3 (en)
EA (1) EA003209B1 (en)
ES (1) ES2208239T3 (en)
FR (1) FR2795072B1 (en)
HK (1) HK1032236A1 (en)
HU (1) HUP0002277A3 (en)
NO (1) NO316650B1 (en)
NZ (1) NZ505149A (en)
PL (1) PL199522B1 (en)
PT (1) PT1069132E (en)
SE (1) SE1069132T5 (en)
SI (1) SI1069132T1 (en)
ZA (1) ZA200003034B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001064678A2 (en) * 2000-02-29 2001-09-07 Bristol-Myers Squibb Pharma Company Inhibitors of hepatitis c virus ns3 protease
FR2818277B1 (en) * 2000-12-14 2003-01-24 Servier Lab NOVEL BICYCLIC DERIVATIVES OF AMINO-PYRAZINONES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
AU2003243657A1 (en) * 2002-06-26 2004-01-19 Bristol-Myers Squibb Company Amino-bicyclic pyrazinones and pyridinones
FR2867780B1 (en) * 2004-03-19 2006-05-19 Servier Lab NOVEL 4-OXO-4,6,7,8-TETRAHYDROPYRROLO (1,2-A) PYRAZINE-6-CARBOXAMIDE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
WO2013111107A1 (en) * 2012-01-27 2013-08-01 Novartis Ag Aminopyridine derivatives as plasma kallikrein inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05117276A (en) * 1991-10-23 1993-05-14 Sumitomo Pharmaceut Co Ltd New tricyclic quinoxalinedione derivative
EP0802916A1 (en) * 1994-12-22 1997-10-29 Biochem Pharma Inc Low molecular weight bicyclic thrombin inhibitors
WO1996030396A1 (en) * 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
WO1997030708A1 (en) * 1996-02-22 1997-08-28 Merck & Co., Inc. Pyridinone thrombin inhibitors
US6124291A (en) * 1996-06-18 2000-09-26 Warner-Lambert Company Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors
WO1998009987A1 (en) * 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin
CA2267260A1 (en) * 1996-10-24 1998-04-30 Merck & Co., Inc. Thrombin inhibitors
US5792779A (en) * 1997-02-19 1998-08-11 Merck & Co., Inc. Pyridinone thrombin inhibitors
WO1999015169A1 (en) * 1997-09-23 1999-04-01 Merck & Co., Inc. Thrombin inhibitors

Also Published As

Publication number Publication date
CN1277198A (en) 2000-12-20
DK1069132T3 (en) 2004-02-02
EA200000527A3 (en) 2001-04-23
SE1069132T3 (en) 2003-12-09
AU4086500A (en) 2000-12-21
US6277851B1 (en) 2001-08-21
CA2312206C (en) 2004-07-06
ZA200003034B (en) 2001-01-11
AU766194B2 (en) 2003-10-09
HU0002277D0 (en) 2000-08-28
JP3364472B2 (en) 2003-01-08
NZ505149A (en) 2001-01-26
EA200000527A2 (en) 2000-12-25
FR2795072B1 (en) 2001-07-27
PT1069132E (en) 2004-02-27
NO316650B1 (en) 2004-03-22
HK1032236A1 (en) 2001-07-13
CN1147489C (en) 2004-04-28
DE60005609D1 (en) 2003-11-06
EP1069132A1 (en) 2001-01-17
ATE251177T1 (en) 2003-10-15
NO20002941L (en) 2000-12-18
NO20002941D0 (en) 2000-06-08
FR2795072A1 (en) 2000-12-22
DE60005609T2 (en) 2004-08-05
EP1069132B1 (en) 2003-10-01
CA2312206A1 (en) 2000-12-15
PL199522B1 (en) 2008-09-30
JP2001026592A (en) 2001-01-30
HUP0002277A3 (en) 2002-12-28
EA003209B1 (en) 2003-02-27
SI1069132T1 (en) 2003-12-31
BR0002643A (en) 2001-01-02
KR20010066846A (en) 2001-07-11
SE1069132T5 (en) 2004-01-07
KR100456796B1 (en) 2004-11-10
ES2208239T3 (en) 2004-06-16
HUP0002277A2 (en) 2001-05-28

Similar Documents

Publication Publication Date Title
NZ518144A (en) Piperazine Compounds
TW200612920A (en) Novel imidazolidine derivatives
BR9713351A (en) N- (aryl / heteroaryl / alkylacetyl) amino acid amides, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by the use of such compounds
GB0117583D0 (en) Novel compounds
EP1103552A4 (en) Benzothiepin derivatives, process for the preparation of the same and uses thereof
DK1249461T3 (en) Acid-blocked amine catalysts for the production of polyurethanes
MY123467A (en) Preparation of sterically hindered amine ethers
EA200600487A1 (en) COMPOUNDS OF INDANILPIPERAZIN, METHOD OF THEIR RECEIVING AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS
PL340784A1 (en) Novel bicyclic compounds of amino pyrazinone, method of obtaining them and pharmacological compositions containing such compounds
NZ514758A (en) Cyclobutenedione compounds to treat conditions in which endothelial dysfunction is known
GB0317920D0 (en) Solid-phase synthesis
DK0635497T3 (en) Benzospiroalken derivatives, processes for their preparation and pharmaceutical compositions containing them
MXPA04003568A (en) Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same.
EA200101204A1 (en) NEW BICYCLIC COMPOUNDS OF AMINOPYRASINONE, METHOD OF THEIR PRODUCTION AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS
EA200200665A1 (en) NEW COMPOUNDS OF BENZOLSULFONAMIDE, METHOD OF THEIR RECEIVING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EA200200682A1 (en) NEW COMPOUNDS OF N-BENZYLPIPERASINE, METHOD OF THEIR RECEIVING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EA200000929A2 (en) New cyano-indole serotonin-reuptake inhibitor compound, method of preparing and containing their pharmaceutical composition
EA200001248A1 (en) NEW LINEAR AND CYCLIC URINE DERIVATIVES, METHOD OF THEIR RECEPTION AND THEIR CONTAINING PHARMACEUTICAL COMPOSITIONS
HUP0102350A2 (en) Propenyl cephalosporin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
NZ508141A (en) Substituted dithio-bis-nitrobenzenes and their use as screening inhibitors of NAD(P)H-dependent disulphide reductase enzymes
BG100704A (en) New piperazine derivatives and methods for their preparation as well as of the compounds containing them
NO20022891L (en) New Cyclic &lt;alfa&gt; -amino- &lt;gamma&gt; -hydroxyamide Compounds, Methods of their Preparation and Pharmaceutical Compositions Containing Them
US20030119671A1 (en) Thiazole-substituted beta-lactams
TH22954A (en) Heterocyclic spiro derivatives
TH58467B (en) Baishichol (2.2.1), heptens and related compounds.

Legal Events

Date Code Title Description
LAPS Decisions on the lapse of the protection rights

Effective date: 20120615