PL321246A1 - Method of preventing transplant rejections - Google Patents

Method of preventing transplant rejections

Info

Publication number
PL321246A1
PL321246A1 PL96321246A PL32124696A PL321246A1 PL 321246 A1 PL321246 A1 PL 321246A1 PL 96321246 A PL96321246 A PL 96321246A PL 32124696 A PL32124696 A PL 32124696A PL 321246 A1 PL321246 A1 PL 321246A1
Authority
PL
Poland
Prior art keywords
donor tissue
apc
tissue
photosensitizing agent
allografts
Prior art date
Application number
PL96321246A
Inventor
Modestus Onuora Kay Obochi
Julia Levy
Original Assignee
Quadra Logic Tech Inc
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadra Logic Tech Inc, Univ British Columbia filed Critical Quadra Logic Tech Inc
Publication of PL321246A1 publication Critical patent/PL321246A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transplanting Machines (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

A method for reducing the rejection of allografts comprising donor tissue containing antigen presenting cells (APC's), which method comprises: a) contacting the donor tissue with a photosensitizing agent to obtain a modified donor tissue; b) exposing the modified donor tissue to light having a wavelength absorbed by the photosensitizing agent for a time sufficient to deplete the APC's in the donor tissue; and c) transplanting the APC-depleted donor tissue into the tissue of a recipient. By subjecting donor tissue to photodynamic therapy, the mean survival time of grafts, particularly skin allografts, was significantly lengthened. The photosensitizer may also be part of a conjugate containing a target-specific moiety.
PL96321246A 1995-01-13 1996-01-12 Method of preventing transplant rejections PL321246A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37170795A 1995-01-13 1995-01-13
PCT/CA1996/000019 WO1996021466A1 (en) 1995-01-13 1996-01-12 Method to prevent transplant rejection

Publications (1)

Publication Number Publication Date
PL321246A1 true PL321246A1 (en) 1997-11-24

Family

ID=23465087

Family Applications (1)

Application Number Title Priority Date Filing Date
PL96321246A PL321246A1 (en) 1995-01-13 1996-01-12 Method of preventing transplant rejections

Country Status (18)

Country Link
EP (1) EP0804238B1 (en)
JP (1) JP3702330B2 (en)
KR (1) KR19980701317A (en)
CN (1) CN1192157A (en)
AT (1) ATE277636T1 (en)
AU (1) AU693634B2 (en)
CA (1) CA2210109C (en)
CZ (1) CZ214697A3 (en)
DE (1) DE69633494T2 (en)
ES (1) ES2227578T3 (en)
FI (1) FI972953A (en)
HU (1) HUP9801123A3 (en)
NO (1) NO973251L (en)
NZ (1) NZ298355A (en)
PL (1) PL321246A1 (en)
SK (1) SK93797A3 (en)
TW (1) TW426518B (en)
WO (1) WO1996021466A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882328A (en) * 1995-01-13 1999-03-16 Qlt Phototherapeutics, Inc. Method to prevent transplant rejection
US6107325A (en) * 1995-01-17 2000-08-22 Qlt Phototherapeutics, Inc. Green porphyrins as immunomodulators
US6096776A (en) * 1995-01-17 2000-08-01 Qlt Phototherapeutics, Inc. Green porphyrins as immunomodulators
US5789433A (en) * 1995-01-17 1998-08-04 Quadra Logic Technologies, Inc. Green porphyrins as immunomodulators
US5824080A (en) * 1995-09-28 1998-10-20 The General Hospital Corporation Photochemistry for the preparation of biologic grafts--allografts and xenografts
CN1149101C (en) * 1997-05-16 2004-05-12 Qlt光治疗股份有限公司 Green porphyrins as immunomodulators
US6364907B1 (en) 1998-10-09 2002-04-02 Qlt Inc. Method to prevent xenograft transplant rejection
US6197294B1 (en) 1998-10-26 2001-03-06 Neurotech S.A. Cell surface molecule-induced macrophage activation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028594A (en) * 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US5147289A (en) * 1990-03-29 1992-09-15 Therakos, Inc Non-specific immune system enhancement
US5820872A (en) * 1992-11-18 1998-10-13 Yale University Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor

Also Published As

Publication number Publication date
NZ298355A (en) 2000-02-28
ATE277636T1 (en) 2004-10-15
CA2210109A1 (en) 1996-07-18
NO973251D0 (en) 1997-07-11
CZ214697A3 (en) 1997-12-17
NO973251L (en) 1997-09-08
CA2210109C (en) 2008-09-23
SK93797A3 (en) 1998-01-14
TW426518B (en) 2001-03-21
CN1192157A (en) 1998-09-02
WO1996021466A1 (en) 1996-07-18
HUP9801123A3 (en) 1999-12-28
ES2227578T3 (en) 2005-04-01
AU693634B2 (en) 1998-07-02
MX9705268A (en) 1997-10-31
DE69633494D1 (en) 2004-11-04
EP0804238A1 (en) 1997-11-05
FI972953A0 (en) 1997-07-11
JP2001526623A (en) 2001-12-18
HUP9801123A2 (en) 1998-08-28
AU4381896A (en) 1996-07-31
FI972953A (en) 1997-09-08
KR19980701317A (en) 1998-05-15
JP3702330B2 (en) 2005-10-05
DE69633494T2 (en) 2005-10-20
EP0804238B1 (en) 2004-09-29

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