FI972953A - Method for preventing graft rejection - Google Patents

Method for preventing graft rejection Download PDF

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Publication number
FI972953A
FI972953A FI972953A FI972953A FI972953A FI 972953 A FI972953 A FI 972953A FI 972953 A FI972953 A FI 972953A FI 972953 A FI972953 A FI 972953A FI 972953 A FI972953 A FI 972953A
Authority
FI
Finland
Prior art keywords
donor tissue
apc
tissue
photosensitizing agent
allografts
Prior art date
Application number
FI972953A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI972953A0 (en
Inventor
Julia Levy
Modestus Onuora Kay Obochi
Original Assignee
Quadra Logic Tech Inc
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadra Logic Tech Inc, Univ British Columbia filed Critical Quadra Logic Tech Inc
Publication of FI972953A0 publication Critical patent/FI972953A0/en
Publication of FI972953A publication Critical patent/FI972953A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

A method for reducing the rejection of allografts comprising donor tissue containing antigen presenting cells (APC's), which method comprises: a) contacting the donor tissue with a photosensitizing agent to obtain a modified donor tissue; b) exposing the modified donor tissue to light having a wavelength absorbed by the photosensitizing agent for a time sufficient to deplete the APC's in the donor tissue; and c) transplanting the APC-depleted donor tissue into the tissue of a recipient. By subjecting donor tissue to photodynamic therapy, the mean survival time of grafts, particularly skin allografts, was significantly lengthened. The photosensitizer may also be part of a conjugate containing a target-specific moiety.
FI972953A 1995-01-13 1997-07-11 Method for preventing graft rejection FI972953A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37170795A 1995-01-13 1995-01-13
PCT/CA1996/000019 WO1996021466A1 (en) 1995-01-13 1996-01-12 Method to prevent transplant rejection

Publications (2)

Publication Number Publication Date
FI972953A0 FI972953A0 (en) 1997-07-11
FI972953A true FI972953A (en) 1997-09-08

Family

ID=23465087

Family Applications (1)

Application Number Title Priority Date Filing Date
FI972953A FI972953A (en) 1995-01-13 1997-07-11 Method for preventing graft rejection

Country Status (18)

Country Link
EP (1) EP0804238B1 (en)
JP (1) JP3702330B2 (en)
KR (1) KR19980701317A (en)
CN (1) CN1192157A (en)
AT (1) ATE277636T1 (en)
AU (1) AU693634B2 (en)
CA (1) CA2210109C (en)
CZ (1) CZ214697A3 (en)
DE (1) DE69633494T2 (en)
ES (1) ES2227578T3 (en)
FI (1) FI972953A (en)
HU (1) HUP9801123A3 (en)
NO (1) NO973251L (en)
NZ (1) NZ298355A (en)
PL (1) PL321246A1 (en)
SK (1) SK93797A3 (en)
TW (1) TW426518B (en)
WO (1) WO1996021466A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882328A (en) * 1995-01-13 1999-03-16 Qlt Phototherapeutics, Inc. Method to prevent transplant rejection
US6107325A (en) * 1995-01-17 2000-08-22 Qlt Phototherapeutics, Inc. Green porphyrins as immunomodulators
US5789433A (en) * 1995-01-17 1998-08-04 Quadra Logic Technologies, Inc. Green porphyrins as immunomodulators
US6096776A (en) * 1995-01-17 2000-08-01 Qlt Phototherapeutics, Inc. Green porphyrins as immunomodulators
US5824080A (en) * 1995-09-28 1998-10-20 The General Hospital Corporation Photochemistry for the preparation of biologic grafts--allografts and xenografts
CN1149101C (en) * 1997-05-16 2004-05-12 Qlt光治疗股份有限公司 Green porphyrins as immunomodulators
US6364907B1 (en) 1998-10-09 2002-04-02 Qlt Inc. Method to prevent xenograft transplant rejection
US6197294B1 (en) 1998-10-26 2001-03-06 Neurotech S.A. Cell surface molecule-induced macrophage activation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028594A (en) * 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US5147289A (en) * 1990-03-29 1992-09-15 Therakos, Inc Non-specific immune system enhancement
US5820872A (en) * 1992-11-18 1998-10-13 Yale University Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor

Also Published As

Publication number Publication date
CZ214697A3 (en) 1997-12-17
HUP9801123A3 (en) 1999-12-28
DE69633494D1 (en) 2004-11-04
EP0804238B1 (en) 2004-09-29
ES2227578T3 (en) 2005-04-01
NZ298355A (en) 2000-02-28
FI972953A0 (en) 1997-07-11
SK93797A3 (en) 1998-01-14
JP2001526623A (en) 2001-12-18
NO973251L (en) 1997-09-08
HUP9801123A2 (en) 1998-08-28
CN1192157A (en) 1998-09-02
CA2210109A1 (en) 1996-07-18
KR19980701317A (en) 1998-05-15
JP3702330B2 (en) 2005-10-05
PL321246A1 (en) 1997-11-24
WO1996021466A1 (en) 1996-07-18
EP0804238A1 (en) 1997-11-05
NO973251D0 (en) 1997-07-11
DE69633494T2 (en) 2005-10-20
AU4381896A (en) 1996-07-31
ATE277636T1 (en) 2004-10-15
MX9705268A (en) 1997-10-31
CA2210109C (en) 2008-09-23
AU693634B2 (en) 1998-07-02
TW426518B (en) 2001-03-21

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