PL3069606T3 - Wektor celujący w gen receptora gamma interleukiny 2, otrzymywanie transgenicznej klonowanej świni miniaturowej z niedoborem komórek odpornościowych mającej wprowadzony do niej wektor, sposób jej wytwarzania oraz zastosowanie - Google Patents

Wektor celujący w gen receptora gamma interleukiny 2, otrzymywanie transgenicznej klonowanej świni miniaturowej z niedoborem komórek odpornościowych mającej wprowadzony do niej wektor, sposób jej wytwarzania oraz zastosowanie

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Publication number
PL3069606T3
PL3069606T3 PL14862785.4T PL14862785T PL3069606T3 PL 3069606 T3 PL3069606 T3 PL 3069606T3 PL 14862785 T PL14862785 T PL 14862785T PL 3069606 T3 PL3069606 T3 PL 3069606T3
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PL
Poland
Prior art keywords
vector
interleukin
preparation
production
immune cell
Prior art date
Application number
PL14862785.4T
Other languages
English (en)
Inventor
Jin-Hoi Kim
Deug-Nam KWON
Kiho Lee
Randall S. Prather
Original Assignee
Jin-Hoi Kim
The Curators Of The University Of Missouri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jin-Hoi Kim, The Curators Of The University Of Missouri filed Critical Jin-Hoi Kim
Publication of PL3069606T3 publication Critical patent/PL3069606T3/pl

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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276Knock-out vertebrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877Techniques for producing new mammalian cloned embryos
    • C12N15/8778Swine embryos
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656Adult fibroblasts
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56977HLA or MHC typing
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/054Animals comprising random inserted nucleic acids (transgenic) inducing loss of function
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/108Swine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/035Animal model for multifactorial diseases
    • A01K2267/0387Animal model for diseases of the immune system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7155Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL14862785.4T 2013-11-13 2014-11-13 Wektor celujący w gen receptora gamma interleukiny 2, otrzymywanie transgenicznej klonowanej świni miniaturowej z niedoborem komórek odpornościowych mającej wprowadzony do niej wektor, sposób jej wytwarzania oraz zastosowanie PL3069606T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020130137675A KR101566498B1 (ko) 2013-11-13 2013-11-13 인터루킨 2 수용체 감마 유전자 적중벡터, 그 벡터가 도입된 면역세포 결핍 형질전환 미니 복제돼지 생산과 그 제조방법 및 활용
PCT/KR2014/010897 WO2015072761A1 (ko) 2013-11-13 2014-11-13 인터루킨 2 수용체 감마 유전자 적중벡터, 그 벡터가 도입된 면역세포 결핍 형질전환 미니 복제돼지 생산과 그 제조방법 및 활용

Publications (1)

Publication Number Publication Date
PL3069606T3 true PL3069606T3 (pl) 2023-03-13

Family

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Family Applications (1)

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PL14862785.4T PL3069606T3 (pl) 2013-11-13 2014-11-13 Wektor celujący w gen receptora gamma interleukiny 2, otrzymywanie transgenicznej klonowanej świni miniaturowej z niedoborem komórek odpornościowych mającej wprowadzony do niej wektor, sposób jej wytwarzania oraz zastosowanie

Country Status (9)

Country Link
US (1) US10058079B2 (pl)
EP (1) EP3069606B1 (pl)
JP (1) JP6464167B2 (pl)
KR (1) KR101566498B1 (pl)
CN (1) CN105764335B (pl)
DK (1) DK3069606T3 (pl)
ES (1) ES2935400T3 (pl)
PL (1) PL3069606T3 (pl)
WO (1) WO2015072761A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108690125B (zh) * 2017-04-07 2021-03-23 百奥赛图(北京)医药科技股份有限公司 Il2rg基因敲除的动物模型的构建方法及其短肽
CN109777834A (zh) * 2019-02-25 2019-05-21 中国科学院广州生物医药与健康研究院 一种重度免疫缺陷猪模型及其构建方法和应用
KR102247977B1 (ko) * 2019-11-21 2021-05-04 한국생명공학연구원 IL2Rg 유전자 돌연변이 면역부전 동물모델 및 그 제조방법
CN111485002A (zh) * 2020-05-06 2020-08-04 澎立生物医药技术(上海)有限公司 一种重度免疫缺陷的转基因小鼠的制备方法及其应用
KR102421847B1 (ko) 2020-11-03 2022-07-18 한국생명공학연구원 Jak3 유전자 돌연변이 중증복합면역결핍 동물모델 및 이의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040074108A (ko) 2004-06-29 2004-08-21 황우석 지에프피 유전자가 발현되는 돼지, 또는 지티 유전자가제거된 복제돼지 및 이들의 생산방법
KR101312829B1 (ko) 2009-12-30 2013-09-27 한화엘앤씨 주식회사 HO-1 유전자 및 TNFR1-Fc 유전자를 동시에 발현하는 형질전환 돼지 및 그의 제조 방법
EP3461898A1 (en) 2011-02-25 2019-04-03 The University Court Of The University of Edinburgh Genetically modified animals and methods for making the same
CN103184202B (zh) 2011-12-28 2015-08-26 浙江大学 一对短肽、蛋白质和多核苷酸、其宿主细胞及其应用
EP2847335B1 (en) * 2012-04-25 2018-06-27 Regeneron Pharmaceuticals, Inc. Nuclease-mediated targeting with large targeting vectors
KR101554166B1 (ko) 2013-11-13 2015-09-22 건국대학교 산학협력단 재조합 활성 유전자 2 유전자 적중벡터, 그 벡터가 도입된 면역세포 결핍 형질전환 미니 복제돼지 생산과 그 제조방법 및 활용
MX2016014066A (es) * 2014-04-28 2017-05-03 Recombinetics Inc Edicion de genes multiples en cerdos.

Also Published As

Publication number Publication date
EP3069606A4 (en) 2017-04-12
JP2016538849A (ja) 2016-12-15
CN105764335A (zh) 2016-07-13
EP3069606B1 (en) 2023-01-04
KR20150055664A (ko) 2015-05-22
DK3069606T3 (da) 2023-01-09
CN105764335B (zh) 2019-05-28
US20160366861A1 (en) 2016-12-22
WO2015072761A1 (ko) 2015-05-21
KR101566498B1 (ko) 2015-11-06
US10058079B2 (en) 2018-08-28
ES2935400T3 (es) 2023-03-06
EP3069606A1 (en) 2016-09-21
JP6464167B2 (ja) 2019-02-06

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