PL297610A1 - - Google Patents

Info

Publication number
PL297610A1
PL297610A1 PL29761091A PL29761091A PL297610A1 PL 297610 A1 PL297610 A1 PL 297610A1 PL 29761091 A PL29761091 A PL 29761091A PL 29761091 A PL29761091 A PL 29761091A PL 297610 A1 PL297610 A1 PL 297610A1
Authority
PL
Poland
Prior art keywords
glycosylated
alpha
objects
producing
same
Prior art date
Application number
PL29761091A
Other languages
English (en)
Inventor
Adolf Gunther
Adolf Himmler
Horst Johann Ahorn
Inge Kalsner
Ingrid Maurer-Fogy
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19904021917 external-priority patent/DE4021917A1/de
Priority claimed from DE19904035877 external-priority patent/DE4035877A1/de
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of PL297610A1 publication Critical patent/PL297610A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
PL29761091A 1990-07-10 1991-07-06 PL297610A1 (cg-RX-API-DMAC7.html)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19904021917 DE4021917A1 (de) 1990-07-10 1990-07-10 Glykosyliertes ifnalpha
DE19904035877 DE4035877A1 (de) 1990-11-12 1990-11-12 O-glycosyliertes ifn-alfa2

Publications (1)

Publication Number Publication Date
PL297610A1 true PL297610A1 (cg-RX-API-DMAC7.html) 1992-07-13

Family

ID=25894855

Family Applications (1)

Application Number Title Priority Date Filing Date
PL29761091A PL297610A1 (cg-RX-API-DMAC7.html) 1990-07-10 1991-07-06

Country Status (16)

Country Link
EP (1) EP0538300B1 (cg-RX-API-DMAC7.html)
JP (1) JPH06502987A (cg-RX-API-DMAC7.html)
KR (1) KR930701601A (cg-RX-API-DMAC7.html)
AT (1) ATE104348T1 (cg-RX-API-DMAC7.html)
AU (1) AU650893B2 (cg-RX-API-DMAC7.html)
CA (1) CA2084514A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ386392A3 (cg-RX-API-DMAC7.html)
DE (1) DE59101397D1 (cg-RX-API-DMAC7.html)
DK (1) DK0538300T3 (cg-RX-API-DMAC7.html)
ES (1) ES2063515T3 (cg-RX-API-DMAC7.html)
FI (1) FI930058L (cg-RX-API-DMAC7.html)
HU (1) HUT65846A (cg-RX-API-DMAC7.html)
NO (1) NO930059D0 (cg-RX-API-DMAC7.html)
PL (1) PL297610A1 (cg-RX-API-DMAC7.html)
SK (1) SK386392A3 (cg-RX-API-DMAC7.html)
WO (1) WO1992001055A1 (cg-RX-API-DMAC7.html)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
NZ245771A (en) * 1992-02-07 1994-08-26 New England Medical Center Inc Mammalian gastrin/cholecystokinin b (cck-b) receptor and antagonists
US5541071A (en) * 1992-02-07 1996-07-30 New England Medical Center Hospitals, Inc. Assay for identifying antagonists of gastrin and CCK-B receptors
EP0626448A3 (de) * 1993-05-26 1998-01-14 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung und Reinigung von alpha-Interferon
EP0788556A1 (en) 1994-10-28 1997-08-13 Innogenetics N.V. New polynucleic acid sequences for use in the detection and differentiation of prokaryotic organisms
EP0920522B1 (en) * 1996-08-14 2003-10-29 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES A vector for polynucleotide vaccines
GB9904695D0 (en) * 1999-03-01 1999-04-21 Imp Cancer Res Tech Peptide
EP1983055A1 (en) 2000-04-12 2008-10-22 Human Genome Sciences, Inc. Albumin fusion proteins
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
DK2322229T3 (en) * 2001-10-10 2017-03-27 Novo Nordisk As Remodeling and Glycoconjugation of Factor IX
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
BRPI0408358A (pt) 2003-03-14 2006-03-21 Neose Technologies Inc polìmeros hidrossolúveis ramificados e seus conjugados
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
US20070026485A1 (en) 2003-04-09 2007-02-01 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
ES2560657T3 (es) 2004-01-08 2016-02-22 Ratiopharm Gmbh Glicosilación con unión en O de péptidos G-CSF
EP1771066A2 (en) 2004-07-13 2007-04-11 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1
US8268967B2 (en) 2004-09-10 2012-09-18 Novo Nordisk A/S Glycopegylated interferon α
JP5948627B2 (ja) 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー 線維芽細胞成長因子（ｆｇｆ）のリモデリングと糖質ペグ化
NZ556436A (en) 2005-01-10 2010-11-26 Biogenerix Ag Glycopegylated granulocyte colony stimulating factor
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20080255026A1 (en) 2005-05-25 2008-10-16 Glycopegylated Factor 1X Glycopegylated Factor Ix
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
AR078117A1 (es) 2006-06-20 2011-10-19 Protech Pharma S A Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina
US20080248959A1 (en) 2006-07-21 2008-10-09 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
EP2054521A4 (en) 2006-10-03 2012-12-19 Novo Nordisk As PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES
US9050304B2 (en) 2007-04-03 2015-06-09 Ratiopharm Gmbh Methods of treatment using glycopegylated G-CSF
WO2008154639A2 (en) 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
ES2476690T3 (es) 2008-02-27 2014-07-15 Novo Nordisk A/S Moléculas conjugadas del Factor VIII
WO2014102103A2 (en) 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Heterologous intron within a signal peptide
WO2014102101A1 (en) 2012-12-31 2014-07-03 Boehringer Ingelheim International Gmbh Novel intron sequences
RU2610173C1 (ru) * 2016-03-30 2017-02-08 Илья Александрович Марков Рекомбинантная плазмида pFM-IFN-17, обеспечивающая экспрессию интерферона альфа-2b человека, рекомбинантная плазмида pFM-АР, обеспечивающая экспрессию фермента метионинаминопептидазы E. coli, биплазмидный штамм Escherichia coli FM-IFN-АР (pFM-IFN-17, pFM-АР) - продуцент (Met-) рекомбинантного интерферона альфа-2b человека

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (cg-RX-API-DMAC7.html) * 1978-11-24 1982-12-04 Hoffmann La Roche
EP0085693A1 (en) * 1981-08-14 1983-08-17 A/S Alfred Benzon Subjects relating to human inteferon-alpha subtype proteins and corresponding antibodies
DE3306060A1 (de) * 1983-02-22 1984-08-23 Boehringer Ingelheim International GmbH, 6507 Ingelheim Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung
FR2560212B1 (fr) * 1984-02-24 1989-12-29 Unicet Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps

Also Published As

Publication number Publication date
SK386392A3 (en) 1994-08-10
DE59101397D1 (de) 1994-05-19
NO930059L (no) 1993-01-08
CA2084514A1 (en) 1992-01-11
FI930058A0 (fi) 1993-01-08
EP0538300A1 (de) 1993-04-28
FI930058A7 (fi) 1993-01-08
AU650893B2 (en) 1994-07-07
HU9300036D0 (en) 1993-04-28
ATE104348T1 (de) 1994-04-15
NO930059D0 (no) 1993-01-08
KR930701601A (ko) 1993-06-12
ES2063515T3 (es) 1995-01-01
FI930058L (fi) 1993-01-08
CZ386392A3 (en) 1993-08-11
JPH06502987A (ja) 1994-04-07
AU8208291A (en) 1992-02-04
DK0538300T3 (da) 1994-10-10
EP0538300B1 (de) 1994-04-13
HUT65846A (en) 1994-07-28
WO1992001055A1 (de) 1992-01-23

Similar Documents

Publication Publication Date Title
PL297610A1 (cg-RX-API-DMAC7.html)
GR3007096T3 (cg-RX-API-DMAC7.html)
ID28003A (id) Turunan-turunan adamantana
UA32512C2 (uk) Похідні ксантину, спосіб їх одержання, та фармацевтична композиція
DK1036058T3 (da) Adamantanderivater
ZA965752B (en) Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents.
AU4048295A (en) Peptide medicaments for the treatment of disease
HU912013D0 (en) Process for the production of benzopyrane derivatives and their heterocyclic analogues, antiyschemic medical preparations
DE58908155D1 (de) Endoprothese des hüftgelenks.
NO912825L (no) Fremgangsmaate for fremstilling av kokonjugatvaksiner omfattende im munogent protein, hiv-beslektede peptider og anioniske grupper.
HU913450D0 (en) Process for the production of cyclopeptides and medical preparations containing them
HU910929D0 (en) Process for the production of 2,8-dioxa-bicyclo/3,2,1/octane derivatives and medical preparations containing them
LTIP709A (en) Sbstituted corticoid-17-alkylcarbonates, process for preparing thereof and pharmaceutical preparations
HU907654D0 (en) Process for the production of medical preparations with increased stabilization, and without tissue-harming effect
HUT58107A (en) Process for producing heparing-binding proteins, dna encoding them and pharmaceutical compositions comprising the proteins
CS265391A3 (en) Novel thienodiazepines, process for their preparation and pharmaceutical comprising them
HU9102385D0 (en) Process for the production of medical preparations
DE68907392D1 (de) Dysmnesie modifizierende arzneimittel.
HUT41002A (en) Process for preparing anticonvulsives
HU912517D0 (en) New 1-diphenyl-methyl-piperazine derivatives, process for their production, and for the production of medical preparations containing thereof
HU913573D0 (en) Complexes containing s(+)alkaneacids and alpha-hydroxy-alkaneacids
HU913345D0 (en) Process for the production of benzopirane derivatives with effect on hypertension and vasodilatation, and medical preparations containing them
HU904211D0 (en) Process for the production of medical preparations containing 10-amino-5,6-dihydro-11h-dibenzo/b,e/azepin-6,11-dion and its derivatives
IL97772A0 (en) Processes for the manufacture of 2-deoxy-d-threo-pentofuranose derivatives,and 2-deoxy-pentofuranose derivatives
GR3005231T3 (cg-RX-API-DMAC7.html)