PL2867361T3 - Masowo równoległa genetyka kombinatoryczna - Google Patents
Masowo równoległa genetyka kombinatorycznaInfo
- Publication number
- PL2867361T3 PL2867361T3 PL13734638T PL13734638T PL2867361T3 PL 2867361 T3 PL2867361 T3 PL 2867361T3 PL 13734638 T PL13734638 T PL 13734638T PL 13734638 T PL13734638 T PL 13734638T PL 2867361 T3 PL2867361 T3 PL 2867361T3
- Authority
- PL
- Poland
- Prior art keywords
- massively parallel
- parallel combinatorial
- combinatorial genetics
- genetics
- massively
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00742—Type of codes
- G01N2035/00752—Type of codes bar codes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261666081P | 2012-06-29 | 2012-06-29 | |
| EP13734638.3A EP2867361B1 (en) | 2012-06-29 | 2013-06-28 | Massively parallel combinatorial genetics |
| PCT/US2013/048619 WO2014005042A2 (en) | 2012-06-29 | 2013-06-28 | Massively parallel combinatorial genetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2867361T3 true PL2867361T3 (pl) | 2018-07-31 |
Family
ID=48747811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13734638T PL2867361T3 (pl) | 2012-06-29 | 2013-06-28 | Masowo równoległa genetyka kombinatoryczna |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9315806B2 (pl) |
| EP (1) | EP2867361B1 (pl) |
| JP (1) | JP6401700B2 (pl) |
| CN (1) | CN104508130B (pl) |
| AU (1) | AU2013282323B2 (pl) |
| CA (1) | CA2877962C (pl) |
| DK (1) | DK2867361T3 (pl) |
| ES (1) | ES2663424T3 (pl) |
| NO (1) | NO2897610T3 (pl) |
| PL (1) | PL2867361T3 (pl) |
| PT (1) | PT2867361T (pl) |
| SG (1) | SG11201408736SA (pl) |
| WO (1) | WO2014005042A2 (pl) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| JP6232074B2 (ja) * | 2012-12-19 | 2017-11-15 | ヘルゲ・ジーラー | 改変され、そして改善された細胞および生物を生成するための組成物および方法 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| CN111218447B (zh) | 2013-11-07 | 2024-10-11 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| JP6600349B2 (ja) | 2014-07-07 | 2019-10-30 | アストレゴ ダイアグノスティクス エービー | 遺伝子的に異なる細胞のライブラリーの表現型特徴付けおよびインサイチュ遺伝子型決定 |
| US11254933B2 (en) | 2014-07-14 | 2022-02-22 | The Regents Of The University Of California | CRISPR/Cas transcriptional modulation |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US20190100769A1 (en) * | 2014-10-31 | 2019-04-04 | Massachusetts Institute Of Technology | Massively parallel combinatorial genetics for crispr |
| US20170369878A1 (en) * | 2015-01-12 | 2017-12-28 | Massachusetts Institute Of Technology | Microrna combinations for anti-cancer therapeutics |
| JP7166168B2 (ja) | 2015-07-30 | 2022-11-07 | マサチューセッツ アイ アンド イヤー インファーマリー | 祖先ウイルス配列およびその使用 |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| CN109072233A (zh) * | 2016-04-26 | 2018-12-21 | 麻省理工学院 | 可扩展的重组酶级联 |
| US11293033B2 (en) | 2016-05-18 | 2022-04-05 | Amyris, Inc. | Compositions and methods for genomic integration of nucleic acids into exogenous landing pads |
| GB2568182A (en) | 2016-08-03 | 2019-05-08 | Harvard College | Adenosine nucleobase editors and uses thereof |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN107784198B (zh) * | 2016-08-26 | 2021-06-15 | 深圳华大基因科技服务有限公司 | 一种二代序列和三代单分子实时测序序列联合组装方法和系统 |
| GB2573062A (en) | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
| CN110312825A (zh) | 2016-10-24 | 2019-10-08 | 吉内恩福赛克公司 | 隐藏核酸内存在的信息 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| US11268082B2 (en) | 2017-03-23 | 2022-03-08 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11293018B2 (en) | 2017-06-09 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Manipulation of nuclear architecture |
| JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化（ｐａｃｅ）を用いて塩基編集因子を進化させるための方法および組成物 |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3775266A4 (en) | 2018-04-05 | 2021-06-30 | Massachusetts Eye and Ear Infirmary | METHOD OF MANUFACTURING AND USING COMBINATIONAL BAR-CODED NUCLEIC ACID LIBRARIES WITH DEFINED VARIATION |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020057481A1 (en) | 2018-09-19 | 2020-03-26 | The University Of Hong Kong | Improved high-throughput combinatorial genetic modification system and optimized cas9 enzyme variants |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN109801679B (zh) * | 2019-01-15 | 2021-02-02 | 广州柿宝生物科技有限公司 | 一种用于长链分子的数学序列重建方法 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020163779A1 (en) * | 2019-02-08 | 2020-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | Production and tracking of engineered cells with combinatorial genetic modifications |
| AU2020240109A1 (en) | 2019-03-19 | 2021-09-30 | President And Fellows Of Harvard College | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CA3130449A1 (en) * | 2019-04-30 | 2020-11-05 | Gigagen, Inc. | Recombinant polyclonal proteins and methods of use thereof |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
| CA3177152A1 (en) | 2020-06-12 | 2021-12-16 | David Scott Johnson | Recombinant polyclonal proteins targeting covid-19 and methods of use thereof |
| EP4388137A1 (en) | 2021-08-19 | 2024-06-26 | Engine Biosciences Pte. Ltd. | Compositions and methods for generating synthetic lethality in tumors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US211103A (en) | 1879-01-07 | Improvement in nut-locks | ||
| DE60141533D1 (de) * | 2000-12-08 | 2010-04-22 | Life Technologies Corp | Ukleinsäuremolekülen unter verwendung multipler erkennungsstellen |
| SG149007A1 (en) | 2003-09-10 | 2009-01-29 | Althea Technologies Inc | Expression profiling using microarrays |
| US20080269068A1 (en) | 2007-02-06 | 2008-10-30 | President And Fellows Of Harvard College | Multiplex decoding of sequence tags in barcodes |
| US8268564B2 (en) | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
| CN102282255B (zh) * | 2008-11-19 | 2014-05-07 | 阿迈瑞斯公司 | 多核苷酸装配的组合物和方法 |
| WO2011140510A2 (en) | 2010-05-06 | 2011-11-10 | Bioo Scientific Corporation | Oligonucleotide ligation, barcoding and methods and compositions for improving data quality and throughput using massively parallel sequencing |
| WO2012019765A1 (en) | 2010-08-10 | 2012-02-16 | European Molecular Biology Laboratory (Embl) | Methods and systems for tracking samples and sample combinations |
-
2013
- 2013-06-28 AU AU2013282323A patent/AU2013282323B2/en active Active
- 2013-06-28 EP EP13734638.3A patent/EP2867361B1/en active Active
- 2013-06-28 SG SG11201408736SA patent/SG11201408736SA/en unknown
- 2013-06-28 US US14/411,628 patent/US9315806B2/en active Active
- 2013-06-28 JP JP2015520583A patent/JP6401700B2/ja active Active
- 2013-06-28 CA CA2877962A patent/CA2877962C/en active Active
- 2013-06-28 WO PCT/US2013/048619 patent/WO2014005042A2/en not_active Ceased
- 2013-06-28 ES ES13734638.3T patent/ES2663424T3/es active Active
- 2013-06-28 CN CN201380040777.4A patent/CN104508130B/zh active Active
- 2013-06-28 PL PL13734638T patent/PL2867361T3/pl unknown
- 2013-06-28 PT PT137346383T patent/PT2867361T/pt unknown
- 2013-06-28 DK DK13734638.3T patent/DK2867361T3/da active
- 2013-09-19 NO NO13839158A patent/NO2897610T3/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2877962A1 (en) | 2014-01-03 |
| HK1207886A1 (en) | 2016-02-12 |
| NO2897610T3 (pl) | 2018-06-09 |
| WO2014005042A2 (en) | 2014-01-03 |
| JP2015521850A (ja) | 2015-08-03 |
| SG11201408736SA (en) | 2015-03-30 |
| DK2867361T3 (da) | 2018-01-29 |
| WO2014005042A3 (en) | 2014-02-27 |
| CN104508130B (zh) | 2016-09-28 |
| AU2013282323B2 (en) | 2018-05-10 |
| PT2867361T (pt) | 2018-02-07 |
| JP6401700B2 (ja) | 2018-10-10 |
| EP2867361B1 (en) | 2017-11-01 |
| US20150141263A1 (en) | 2015-05-21 |
| EP2867361A2 (en) | 2015-05-06 |
| CN104508130A (zh) | 2015-04-08 |
| CA2877962C (en) | 2018-06-05 |
| US9315806B2 (en) | 2016-04-19 |
| AU2013282323A1 (en) | 2015-02-19 |
| HK1210217A1 (en) | 2016-04-15 |
| ES2663424T3 (es) | 2018-04-12 |
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