PL2867361T3 - Masowo równoległa genetyka kombinatoryczna - Google Patents
Masowo równoległa genetyka kombinatorycznaInfo
- Publication number
- PL2867361T3 PL2867361T3 PL13734638T PL13734638T PL2867361T3 PL 2867361 T3 PL2867361 T3 PL 2867361T3 PL 13734638 T PL13734638 T PL 13734638T PL 13734638 T PL13734638 T PL 13734638T PL 2867361 T3 PL2867361 T3 PL 2867361T3
- Authority
- PL
- Poland
- Prior art keywords
- massively parallel
- parallel combinatorial
- combinatorial genetics
- genetics
- massively
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
- G01N2035/00742—Type of codes
- G01N2035/00752—Type of codes bar codes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261666081P | 2012-06-29 | 2012-06-29 | |
| PCT/US2013/048619 WO2014005042A2 (en) | 2012-06-29 | 2013-06-28 | Massively parallel combinatorial genetics |
| EP13734638.3A EP2867361B1 (en) | 2012-06-29 | 2013-06-28 | Massively parallel combinatorial genetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2867361T3 true PL2867361T3 (pl) | 2018-07-31 |
Family
ID=48747811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13734638T PL2867361T3 (pl) | 2012-06-29 | 2013-06-28 | Masowo równoległa genetyka kombinatoryczna |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9315806B2 (pl) |
| EP (1) | EP2867361B1 (pl) |
| JP (1) | JP6401700B2 (pl) |
| CN (1) | CN104508130B (pl) |
| AU (1) | AU2013282323B2 (pl) |
| CA (1) | CA2877962C (pl) |
| DK (1) | DK2867361T3 (pl) |
| ES (1) | ES2663424T3 (pl) |
| HK (2) | HK1207886A1 (pl) |
| NO (1) | NO2897610T3 (pl) |
| PL (1) | PL2867361T3 (pl) |
| PT (1) | PT2867361T (pl) |
| SG (1) | SG11201408736SA (pl) |
| WO (1) | WO2014005042A2 (pl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012333134B2 (en) | 2011-07-22 | 2017-05-25 | John Paul Guilinger | Evaluation and improvement of nuclease cleavage specificity |
| JP6232074B2 (ja) * | 2012-12-19 | 2017-11-15 | ヘルゲ・ジーラー | 改変され、そして改善された細胞および生物を生成するための組成物および方法 |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| WO2015070083A1 (en) | 2013-11-07 | 2015-05-14 | Editas Medicine,Inc. | CRISPR-RELATED METHODS AND COMPOSITIONS WITH GOVERNING gRNAS |
| US9068179B1 (en) | 2013-12-12 | 2015-06-30 | President And Fellows Of Harvard College | Methods for correcting presenilin point mutations |
| CN106471122B (zh) * | 2014-07-07 | 2020-07-03 | 阿斯特瑞格诊断公司 | 在遗传上不同的细胞的文库的表型鉴定及原位基因分型 |
| EP3169776A4 (en) * | 2014-07-14 | 2018-07-04 | The Regents of The University of California | Crispr/cas transcriptional modulation |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| TWI716367B (zh) * | 2014-10-31 | 2021-01-21 | 麻省理工學院 | 用於常間回文重複序列叢集（ｃｒｉｓｐｒ）之大量平行組合性基因學 |
| WO2016115033A1 (en) * | 2015-01-12 | 2016-07-21 | Massachusetts Institute Of Technology | Microrna combinations for anti-cancer therapeutics |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2017189683A1 (en) * | 2016-04-26 | 2017-11-02 | Massachusetts Institute Of Technology | Extensible recombinase cascades |
| WO2017201311A2 (en) * | 2016-05-18 | 2017-11-23 | Amyris, Inc. | Compositions and methods for genomic integration of nucleic acids into exogenous landing pads |
| CA3032699A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN107784198B (zh) * | 2016-08-26 | 2021-06-15 | 深圳华大基因科技服务有限公司 | 一种二代序列和三代单分子实时测序序列联合组装方法和系统 |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| CA3041645C (en) | 2016-10-24 | 2021-11-02 | Geneinfosec, Inc. | Concealing information present within nucleic acids |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| KR102687373B1 (ko) | 2017-03-23 | 2024-07-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11293018B2 (en) | 2017-06-09 | 2022-04-05 | The Board Of Trustees Of The Leland Stanford Junior University | Manipulation of nuclear architecture |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| CN111757937A (zh) | 2017-10-16 | 2020-10-09 | 布罗德研究所股份有限公司 | 腺苷碱基编辑器的用途 |
| WO2019195701A1 (en) | 2018-04-05 | 2019-10-10 | Massachusetts Eye And Ear Infirmary | Methods of making and using combinatorial barcoded nucleic acid libraries having defined variation |
| WO2020057481A1 (en) | 2018-09-19 | 2020-03-26 | The University Of Hong Kong | Improved high-throughput combinatorial genetic modification system and optimized cas9 enzyme variants |
| CN109801679B (zh) * | 2019-01-15 | 2021-02-02 | 广州柿宝生物科技有限公司 | 一种用于长链分子的数学序列重建方法 |
| WO2020191249A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| MX2022014008A (es) | 2020-05-08 | 2023-02-09 | Broad Inst Inc | Métodos y composiciones para la edición simultánea de ambas cadenas de una secuencia de nucleótidos de doble cadena objetivo. |
| EP4388137A1 (en) | 2021-08-19 | 2024-06-26 | Engine Biosciences Pte. Ltd. | Compositions and methods for generating synthetic lethality in tumors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US211103A (en) | 1879-01-07 | Improvement in nut-locks | ||
| CA2430947A1 (en) * | 2000-12-08 | 2002-06-13 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
| CA2536565A1 (en) | 2003-09-10 | 2005-05-12 | Althea Technologies, Inc. | Expression profiling using microarrays |
| US20080269068A1 (en) | 2007-02-06 | 2008-10-30 | President And Fellows Of Harvard College | Multiplex decoding of sequence tags in barcodes |
| US8268564B2 (en) | 2007-09-26 | 2012-09-18 | President And Fellows Of Harvard College | Methods and applications for stitched DNA barcodes |
| BRPI0922187B1 (pt) * | 2008-11-19 | 2021-05-04 | Amyris, Inc | Métodos para gerar um polinucleotídeo e para gerar uma célula hospedeira |
| WO2011140510A2 (en) | 2010-05-06 | 2011-11-10 | Bioo Scientific Corporation | Oligonucleotide ligation, barcoding and methods and compositions for improving data quality and throughput using massively parallel sequencing |
| WO2012019765A1 (en) | 2010-08-10 | 2012-02-16 | European Molecular Biology Laboratory (Embl) | Methods and systems for tracking samples and sample combinations |
-
2013
- 2013-06-28 DK DK13734638.3T patent/DK2867361T3/da active
- 2013-06-28 JP JP2015520583A patent/JP6401700B2/ja active Active
- 2013-06-28 PT PT137346383T patent/PT2867361T/pt unknown
- 2013-06-28 PL PL13734638T patent/PL2867361T3/pl unknown
- 2013-06-28 ES ES13734638.3T patent/ES2663424T3/es active Active
- 2013-06-28 CN CN201380040777.4A patent/CN104508130B/zh active Active
- 2013-06-28 AU AU2013282323A patent/AU2013282323B2/en active Active
- 2013-06-28 EP EP13734638.3A patent/EP2867361B1/en active Active
- 2013-06-28 CA CA2877962A patent/CA2877962C/en active Active
- 2013-06-28 WO PCT/US2013/048619 patent/WO2014005042A2/en active Application Filing
- 2013-06-28 SG SG11201408736SA patent/SG11201408736SA/en unknown
- 2013-06-28 US US14/411,628 patent/US9315806B2/en active Active
- 2013-09-19 NO NO13839158A patent/NO2897610T3/no unknown
-
2015
- 2015-09-01 HK HK15108525.0A patent/HK1207886A1/xx unknown
- 2015-11-06 HK HK15110947.6A patent/HK1210217A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014005042A3 (en) | 2014-02-27 |
| AU2013282323A1 (en) | 2015-02-19 |
| NO2897610T3 (pl) | 2018-06-09 |
| WO2014005042A2 (en) | 2014-01-03 |
| US20150141263A1 (en) | 2015-05-21 |
| CN104508130B (zh) | 2016-09-28 |
| JP6401700B2 (ja) | 2018-10-10 |
| EP2867361A2 (en) | 2015-05-06 |
| DK2867361T3 (da) | 2018-01-29 |
| EP2867361B1 (en) | 2017-11-01 |
| CA2877962C (en) | 2018-06-05 |
| JP2015521850A (ja) | 2015-08-03 |
| US9315806B2 (en) | 2016-04-19 |
| HK1210217A1 (en) | 2016-04-15 |
| ES2663424T3 (es) | 2018-04-12 |
| SG11201408736SA (en) | 2015-03-30 |
| AU2013282323B2 (en) | 2018-05-10 |
| HK1207886A1 (en) | 2016-02-12 |
| CN104508130A (zh) | 2015-04-08 |
| CA2877962A1 (en) | 2014-01-03 |
| PT2867361T (pt) | 2018-02-07 |
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