PL2831279T3 - Szybkie wykrywanie aneuploidii - Google Patents
Szybkie wykrywanie aneuploidiiInfo
- Publication number
- PL2831279T3 PL2831279T3 PL13768366.0T PL13768366T PL2831279T3 PL 2831279 T3 PL2831279 T3 PL 2831279T3 PL 13768366 T PL13768366 T PL 13768366T PL 2831279 T3 PL2831279 T3 PL 2831279T3
- Authority
- PL
- Poland
- Prior art keywords
- aneuploidia
- fast detection
- fast
- detection
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Spectrometry And Color Measurement (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Algebra (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Physics & Mathematics (AREA)
- Mathematical Analysis (AREA)
- Mathematical Optimization (AREA)
- Mathematical Physics (AREA)
- Pure & Applied Mathematics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615535P | 2012-03-26 | 2012-03-26 | |
| US201261659695P | 2012-06-14 | 2012-06-14 | |
| PCT/US2013/033451 WO2013148496A1 (en) | 2012-03-26 | 2013-03-22 | Rapid aneuploidy detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2831279T3 true PL2831279T3 (pl) | 2023-12-04 |
Family
ID=49261127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13768366.0T PL2831279T3 (pl) | 2012-03-26 | 2013-03-22 | Szybkie wykrywanie aneuploidii |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US10053729B2 (pl) |
| EP (2) | EP2831279B1 (pl) |
| CN (2) | CN104350158B (pl) |
| AU (1) | AU2013240088B2 (pl) |
| CA (1) | CA2868836C (pl) |
| ES (1) | ES2945311T3 (pl) |
| FI (1) | FI2831279T3 (pl) |
| HK (1) | HK1205204A1 (pl) |
| IL (1) | IL234850B (pl) |
| PL (1) | PL2831279T3 (pl) |
| WO (1) | WO2013148496A1 (pl) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010126614A2 (en) | 2009-04-30 | 2010-11-04 | Good Start Genetics, Inc. | Methods and compositions for evaluating genetic markers |
| WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US12129514B2 (en) | 2009-04-30 | 2024-10-29 | Molecular Loop Biosolutions, Llc | Methods and compositions for evaluating genetic markers |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| US9371598B2 (en) | 2010-04-05 | 2016-06-21 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| CN103748236B (zh) | 2011-04-15 | 2018-12-25 | 约翰·霍普金斯大学 | 安全测序系统 |
| WO2013058907A1 (en) | 2011-10-17 | 2013-04-25 | Good Start Genetics, Inc. | Analysis methods |
| FI2831279T3 (fi) | 2012-03-26 | 2023-05-23 | Univ Johns Hopkins | Nopea aneuploidian havaitseminen |
| US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
| US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| EP4424826A3 (en) | 2012-09-04 | 2024-11-27 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| EP3511423B2 (en) | 2012-10-17 | 2024-05-29 | Spatial Transcriptomics AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| PL2912468T3 (pl) | 2012-10-29 | 2019-04-30 | Univ Johns Hopkins | Test papanicolaou pod kątem raka jajnika i endometrium |
| US8778609B1 (en) | 2013-03-14 | 2014-07-15 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
| LT3013983T (lt) | 2013-06-25 | 2023-05-10 | Prognosys Biosciences, Inc. | Erdviniai koduoti biologiniai tyrimai, naudojant mikrofluidinį įrenginį |
| US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
| SG11201604923XA (en) | 2013-12-28 | 2016-07-28 | Guardant Health Inc | Methods and systems for detecting genetic variants |
| WO2015175530A1 (en) | 2014-05-12 | 2015-11-19 | Gore Athurva | Methods for detecting aneuploidy |
| WO2016025818A1 (en) | 2014-08-15 | 2016-02-18 | Good Start Genetics, Inc. | Systems and methods for genetic analysis |
| WO2016040446A1 (en) | 2014-09-10 | 2016-03-17 | Good Start Genetics, Inc. | Methods for selectively suppressing non-target sequences |
| JP2017536087A (ja) | 2014-09-24 | 2017-12-07 | グッド スタート ジェネティクス， インコーポレイテッド | 遺伝子アッセイのロバストネスを増大させるためのプロセス制御 |
| EP3835429A1 (en) * | 2014-10-17 | 2021-06-16 | Good Start Genetics, Inc. | Pre-implantation genetic screening and aneuploidy detection |
| EP4095261B1 (en) | 2015-01-06 | 2025-05-28 | Molecular Loop Biosciences, Inc. | Screening for structural variants |
| CA3011029A1 (en) * | 2015-01-15 | 2017-07-21 | Good Start Genetics, Inc. | Methods of quality control using single-nucleotide polymorphisms in pre-implantation genetic screening |
| SG11201707515SA (en) | 2015-04-10 | 2017-10-30 | Spatial Transcriptomics Ab | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| US11286531B2 (en) | 2015-08-11 | 2022-03-29 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| JP2019507585A (ja) | 2015-12-17 | 2019-03-22 | ガーダント ヘルス， インコーポレイテッド | 無細胞ｄｎａの分析による腫瘍遺伝子コピー数を決定するための方法 |
| CN107699607A (zh) * | 2016-08-31 | 2018-02-16 | 刘红彦 | 一种构建胎儿游离dna测序文库的试剂盒、方法及用途 |
| MX2020001575A (es) | 2017-08-07 | 2020-11-18 | Univ Johns Hopkins | Materiales y métodos para evaluar y tratar el cáncer. |
| US20200407794A1 (en) * | 2018-02-28 | 2020-12-31 | ChromaCode, Inc. | Molecular targets for fetal nucleic acid analysis |
| WO2019204357A1 (en) | 2018-04-17 | 2019-10-24 | ChromaCode, Inc. | Methods and systems for multiplex analysis |
| CN108913757B (zh) * | 2018-07-05 | 2021-06-11 | 广州市达瑞生物技术股份有限公司 | 一种染色体非整倍体数目异常的引物组与检测试剂盒及其应用 |
| CN108841931B (zh) * | 2018-07-05 | 2021-06-11 | 广州市达瑞生物技术股份有限公司 | 一种检测人4号染色体str基因座的引物组与检测试剂盒及其应用 |
| US12247249B2 (en) | 2018-12-21 | 2025-03-11 | Inivata Ltd. | Method for amplifying a genomic sample |
| US11100087B2 (en) * | 2019-04-26 | 2021-08-24 | Microsoft Technology Licensing, Llc | Data tokenization system maintaining data integrity |
| MX2021013834A (es) | 2019-05-17 | 2022-06-29 | Univ Johns Hopkins | Detección rápida de aneuploidía. |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| US20220073977A1 (en) | 2020-02-14 | 2022-03-10 | The Johns Hopkins University | Methods and materials for assessing nucleic acids |
| WO2021247543A2 (en) | 2020-06-02 | 2021-12-09 | 10X Genomics, Inc. | Nucleic acid library methods |
| EP4158054B1 (en) | 2020-06-02 | 2025-04-16 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
| ES2981265T3 (es) | 2020-06-08 | 2024-10-08 | 10X Genomics Inc | Métodos para determinar un margen quirúrgico y métodos de uso del mismo |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA43460A (en) | 1893-07-03 | Robert Wellington Bigger | Furnace | |
| CA57345A (en) | 1897-07-30 | 1897-09-04 | Francis Louis Becker | Upright piano-forte action |
| CA62924A (en) | 1898-12-27 | 1899-03-25 | Azarie Mireault | Medicinal compound |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| US6703228B1 (en) * | 1998-09-25 | 2004-03-09 | Massachusetts Institute Of Technology | Methods and products related to genotyping and DNA analysis |
| GB0104690D0 (en) | 2001-02-26 | 2001-04-11 | Cytogenetic Dna Services Ltd | Diagnostic test |
| US20040018506A1 (en) * | 2002-01-25 | 2004-01-29 | Koehler Ryan T. | Methods for placing, accepting, and filling orders for products and services |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| US20060172294A1 (en) * | 2002-06-06 | 2006-08-03 | Arturas Petronis | Detection of epigenetic abnormalities and diagnostic method based thereon |
| US7704687B2 (en) * | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
| AU2003299694A1 (en) * | 2002-12-20 | 2004-07-22 | Qiagen Gmbh | Nucleic acid amplification |
| EP1664077B1 (en) | 2003-09-05 | 2016-04-13 | Trustees of Boston University | Method for non-invasive prenatal diagnosis |
| US7537889B2 (en) | 2003-09-30 | 2009-05-26 | Life Genetics Lab, Llc. | Assay for quantitation of human DNA using Alu elements |
| WO2005035725A2 (en) | 2003-10-08 | 2005-04-21 | The Trustees Of Boston University | Methods for prenatal diagnosis of chromosomal abnormalities |
| US20060019270A1 (en) * | 2004-04-01 | 2006-01-26 | Board Of Regents The University Of Texas System | Global DNA methylation assessment using bisulfite PCR |
| US7709194B2 (en) | 2004-06-04 | 2010-05-04 | The Chinese University Of Hong Kong | Marker for prenatal diagnosis and monitoring |
| EP1859050B1 (en) | 2005-03-18 | 2012-10-24 | The Chinese University Of Hong Kong | A method for the detection of chromosomal aneuploidies |
| EP2385143B1 (en) | 2006-02-02 | 2016-07-13 | The Board of Trustees of the Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
| US20090203002A1 (en) | 2006-03-06 | 2009-08-13 | Columbia University | Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| US12180549B2 (en) * | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| CN106834481A (zh) | 2007-07-23 | 2017-06-13 | 香港中文大学 | 用于分析遗传变异的方法 |
| US8476013B2 (en) * | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| ES2620294T3 (es) * | 2008-09-20 | 2017-06-28 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnóstico no invasivo de la aneuploidia fetal por secuenciación |
| US8563242B2 (en) | 2009-08-11 | 2013-10-22 | The Chinese University Of Hong Kong | Method for detecting chromosomal aneuploidy |
| WO2011066476A1 (en) * | 2009-11-25 | 2011-06-03 | Quantalife, Inc. | Methods and compositions for detecting genetic material |
| US9926593B2 (en) * | 2009-12-22 | 2018-03-27 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
| AU2010343276B2 (en) * | 2010-01-19 | 2015-05-28 | Verinata Health, Inc. | Methods for determining fraction of fetal nucleic acid in maternal samples |
| EP2569447A4 (en) | 2010-05-14 | 2013-11-27 | Fluidigm Corp | ASSAYS FOR THE DETECTION OF GENOTYPES, MUTATIONS OR ANEUPLOIDY |
| FI2831279T3 (fi) | 2012-03-26 | 2023-05-23 | Univ Johns Hopkins | Nopea aneuploidian havaitseminen |
-
2013
- 2013-03-22 FI FIEP13768366.0T patent/FI2831279T3/fi active
- 2013-03-22 PL PL13768366.0T patent/PL2831279T3/pl unknown
- 2013-03-22 EP EP13768366.0A patent/EP2831279B1/en active Active
- 2013-03-22 HK HK15105795.9A patent/HK1205204A1/xx unknown
- 2013-03-22 CA CA2868836A patent/CA2868836C/en active Active
- 2013-03-22 CN CN201380026625.9A patent/CN104350158B/zh active Active
- 2013-03-22 CN CN202010003298.7A patent/CN111073962A/zh active Pending
- 2013-03-22 ES ES13768366T patent/ES2945311T3/es active Active
- 2013-03-22 US US14/388,314 patent/US10053729B2/en active Active
- 2013-03-22 AU AU2013240088A patent/AU2013240088B2/en active Active
- 2013-03-22 EP EP23170939.5A patent/EP4239081A3/en not_active Withdrawn
- 2013-03-22 WO PCT/US2013/033451 patent/WO2013148496A1/en not_active Ceased
-
2014
- 2014-09-28 IL IL234850A patent/IL234850B/en active IP Right Grant
-
2015
- 2015-07-07 US US14/792,716 patent/US20150376691A1/en not_active Abandoned
-
2021
- 2021-09-23 US US17/483,537 patent/US12116628B2/en active Active
-
2024
- 2024-09-12 US US18/883,232 patent/US20250002995A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN104350158A (zh) | 2015-02-11 |
| US20250002995A1 (en) | 2025-01-02 |
| CA2868836A1 (en) | 2013-10-03 |
| AU2013240088A1 (en) | 2014-10-16 |
| ES2945311T3 (es) | 2023-06-30 |
| FI2831279T3 (fi) | 2023-05-23 |
| IL234850A0 (en) | 2014-12-31 |
| HK1206795A1 (en) | 2016-01-15 |
| US10053729B2 (en) | 2018-08-21 |
| US20150051085A1 (en) | 2015-02-19 |
| US20220010371A1 (en) | 2022-01-13 |
| EP4239081A3 (en) | 2023-11-08 |
| CN111073962A (zh) | 2020-04-28 |
| EP2831279B1 (en) | 2023-05-03 |
| HK1205204A1 (en) | 2015-12-11 |
| EP2831279A1 (en) | 2015-02-04 |
| CA2868836C (en) | 2019-08-06 |
| US20150376691A1 (en) | 2015-12-31 |
| WO2013148496A1 (en) | 2013-10-03 |
| AU2013240088B2 (en) | 2017-02-02 |
| EP2831279A4 (en) | 2015-12-30 |
| CN104350158B (zh) | 2025-08-12 |
| US12116628B2 (en) | 2024-10-15 |
| EP4239081A2 (en) | 2023-09-06 |
| IL234850B (en) | 2019-08-29 |
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