PL2722332T3 - Związek chinolilopirolopirymidylowy ze sprzężonym pierścieniem lub jego sól - Google Patents
Związek chinolilopirolopirymidylowy ze sprzężonym pierścieniem lub jego sólInfo
- Publication number
- PL2722332T3 PL2722332T3 PL13745327.0T PL13745327T PL2722332T3 PL 2722332 T3 PL2722332 T3 PL 2722332T3 PL 13745327 T PL13745327 T PL 13745327T PL 2722332 T3 PL2722332 T3 PL 2722332T3
- Authority
- PL
- Poland
- Prior art keywords
- quinolylpyrrolopyrimidyl
- fused
- salt
- ring compound
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012037565 | 2012-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2722332T3 true PL2722332T3 (pl) | 2016-10-31 |
Family
ID=49005885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13745327.0T PL2722332T3 (pl) | 2012-02-23 | 2013-02-22 | Związek chinolilopirolopirymidylowy ze sprzężonym pierścieniem lub jego sól |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8889666B2 (pl) |
| EP (1) | EP2722332B1 (pl) |
| JP (1) | JP5557963B2 (pl) |
| KR (1) | KR101660145B1 (pl) |
| CN (1) | CN104136438B (pl) |
| CA (1) | CA2861980C (pl) |
| DK (1) | DK2722332T3 (pl) |
| ES (1) | ES2580530T3 (pl) |
| HU (1) | HUE029343T2 (pl) |
| MX (1) | MX351863B (pl) |
| PL (1) | PL2722332T3 (pl) |
| RU (1) | RU2581039C1 (pl) |
| SG (1) | SG11201402876UA (pl) |
| TW (1) | TWI496783B (pl) |
| WO (1) | WO2013125709A1 (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014129596A1 (ja) * | 2013-02-22 | 2014-08-28 | 大鵬薬品工業株式会社 | 三環性化合物の製造方法及び当該製造方法により得ることができる三環性化合物 |
| EP3037424B1 (en) * | 2013-08-22 | 2017-11-08 | Taiho Pharmaceutical Co., Ltd. | Novel quinoline-substituted compound |
| DK3279202T3 (da) * | 2015-03-31 | 2020-08-17 | Taiho Pharmaceutical Co Ltd | Krystal af 3,5-disubstitueret benzenalkynylforbindelse |
| WO2017064558A1 (ja) * | 2015-10-14 | 2017-04-20 | 大鵬薬品工業株式会社 | 新規免疫賦活化剤 |
| JOP20190073A1 (ar) | 2016-10-31 | 2019-04-07 | Taiho Pharmaceutical Co Ltd | مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20 |
| CN108101905A (zh) * | 2016-11-24 | 2018-06-01 | 中国科学院上海药物研究所 | 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途 |
| JP7065103B2 (ja) | 2017-09-01 | 2022-05-11 | 大鵬薬品工業株式会社 | エクソン１８及び／又はエクソン２１変異型ｅｇｆｒ選択的阻害剤 |
| CN112574208B (zh) * | 2019-09-29 | 2022-09-13 | 深圳市塔吉瑞生物医药有限公司 | 取代的稠合三环衍生物及其组合物及用途 |
| WO2022121967A1 (zh) * | 2020-12-09 | 2022-06-16 | 南京药石科技股份有限公司 | Egfr酪氨酸激酶抑制剂及其用途 |
| US12037346B2 (en) | 2021-04-13 | 2024-07-16 | Nuvalent, Inc. | Amino-substituted heteroaryls for treating cancers with EGFR mutations |
| CN115785107B (zh) * | 2022-12-15 | 2024-11-12 | 南京雷正医药科技有限公司 | 一种取代8,9-二氢嘧啶并[5,4-b]吲嗪类化合物、药物组合物及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2007138264A (ru) | 2005-03-17 | 2009-09-10 | Новартис АГ (CH) | N-[3-(1-АМИНО-5,6,7,8-ТЕТРАГИДРО-2,4,4b-ТРИАЗАФЛУОРЕН-9-ИЛ)ФЕНИЛ]БЕНЗАМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ТИРОЗИН/ТРЕОНИНКИНАЗ, ПРЕЖДЕ ВСЕГО КИНАЗ В-RAF |
| WO2007075554A2 (en) * | 2005-12-19 | 2007-07-05 | Osi Pharmaceuticals, Inc. | Combination of igfr inhibitor and anti-cancer agent |
| KR101499783B1 (ko) | 2006-04-04 | 2015-03-09 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 키나제 길항물질 |
| EP2051982A1 (en) * | 2006-08-10 | 2009-04-29 | OSI Pharmaceuticals, Inc. | 6,6-bicyclic ring substituted sulfur containing heterobicyclic protein kinase inhibitors |
| EA018573B1 (ru) * | 2006-09-22 | 2013-09-30 | Фармасайкликс, Инк. | Ингибиторы тирозинкиназы брутона |
| SG10201508035TA (en) * | 2007-03-28 | 2015-10-29 | Pharmacyclics Inc | Inhibitors of bruton's tyrosine kinase |
| US7741330B1 (en) * | 2009-10-12 | 2010-06-22 | Pharmacyclics, Inc. | Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase |
| CN102146059A (zh) * | 2010-02-08 | 2011-08-10 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、制备方法及其应用 |
| MX342164B (es) * | 2010-06-23 | 2016-09-19 | Hanmi Science Co Ltd | Derivados de pirimidina fusionados novedosos para la inhibicion de la actividad de tirosina cinasa. |
| NZ710636A (en) * | 2010-11-01 | 2017-02-24 | Celgene Avilomics Res Inc | Heterocyclic compounds and uses thereof |
-
2013
- 2013-02-22 RU RU2014138263/04A patent/RU2581039C1/ru not_active IP Right Cessation
- 2013-02-22 EP EP13745327.0A patent/EP2722332B1/en not_active Not-in-force
- 2013-02-22 MX MX2014009991A patent/MX351863B/es active IP Right Grant
- 2013-02-22 PL PL13745327.0T patent/PL2722332T3/pl unknown
- 2013-02-22 CA CA2861980A patent/CA2861980C/en not_active Expired - Fee Related
- 2013-02-22 HU HUE13745327A patent/HUE029343T2/en unknown
- 2013-02-22 WO PCT/JP2013/054615 patent/WO2013125709A1/ja not_active Ceased
- 2013-02-22 KR KR1020147024020A patent/KR101660145B1/ko not_active Expired - Fee Related
- 2013-02-22 US US13/984,299 patent/US8889666B2/en not_active Expired - Fee Related
- 2013-02-22 TW TW102106272A patent/TWI496783B/zh not_active IP Right Cessation
- 2013-02-22 JP JP2013534872A patent/JP5557963B2/ja not_active Expired - Fee Related
- 2013-02-22 DK DK13745327.0T patent/DK2722332T3/en active
- 2013-02-22 ES ES13745327.0T patent/ES2580530T3/es active Active
- 2013-02-22 CN CN201380010586.3A patent/CN104136438B/zh not_active Expired - Fee Related
- 2013-02-22 SG SG11201402876UA patent/SG11201402876UA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE029343T2 (en) | 2017-02-28 |
| KR20140117647A (ko) | 2014-10-07 |
| SG11201402876UA (en) | 2014-12-30 |
| ES2580530T3 (es) | 2016-08-24 |
| CN104136438A (zh) | 2014-11-05 |
| EP2722332A4 (en) | 2014-04-23 |
| RU2581039C1 (ru) | 2016-04-10 |
| CN104136438B (zh) | 2016-04-06 |
| MX351863B (es) | 2017-10-30 |
| DK2722332T3 (en) | 2016-06-20 |
| WO2013125709A1 (ja) | 2013-08-29 |
| CA2861980A1 (en) | 2013-08-29 |
| JP5557963B2 (ja) | 2014-07-23 |
| CA2861980C (en) | 2016-11-08 |
| KR101660145B1 (ko) | 2016-09-26 |
| TWI496783B (zh) | 2015-08-21 |
| US8889666B2 (en) | 2014-11-18 |
| US20140057899A1 (en) | 2014-02-27 |
| AU2013223052A1 (en) | 2014-07-03 |
| HK1202862A1 (zh) | 2015-10-09 |
| EP2722332B1 (en) | 2016-04-20 |
| TW201339160A (zh) | 2013-10-01 |
| EP2722332A1 (en) | 2014-04-23 |
| MX2014009991A (es) | 2014-09-08 |
| JPWO2013125709A1 (ja) | 2015-07-30 |
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