PL23786B3 - The method of obtaining follicular hormone. - Google Patents
The method of obtaining follicular hormone. Download PDFInfo
- Publication number
- PL23786B3 PL23786B3 PL23786A PL2378634A PL23786B3 PL 23786 B3 PL23786 B3 PL 23786B3 PL 23786 A PL23786 A PL 23786A PL 2378634 A PL2378634 A PL 2378634A PL 23786 B3 PL23786 B3 PL 23786B3
- Authority
- PL
- Poland
- Prior art keywords
- hormone
- alkaline solution
- follicular hormone
- follicular
- aqueous alkaline
- Prior art date
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- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 title claims description 6
- 238000000034 method Methods 0.000 title claims description 3
- 239000012670 alkaline solution Substances 0.000 claims description 6
- 229940088597 hormone Drugs 0.000 claims description 6
- 239000005556 hormone Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000007858 starting material Substances 0.000 claims description 5
- 210000002700 urine Anatomy 0.000 claims description 3
- 229940060367 inert ingredients Drugs 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 239000003960 organic solvent Substances 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
- 230000010933 acylation Effects 0.000 description 2
- 238000005917 acylation reaction Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Description
Najdluiszy czas trwania patentu do 25 wrzesnia 1950 r.Patent Nr 22 179 dotyczy sposobu o- trzymywania hormonu pecherzykowego z moczu i polega na tern, ze materjal wyj¬ sciowy, po odpowiedniej obróbce wstepnej, przeprowadza sie do roztworu alkaliczne¬ go, poddaje dzialaniu srodków acyluja- cych, poczem powstale produkty acylowa- nia oddziela i zmydla.Obecnie wykryto-, ze zamiast moczu o- sób wzglednie zwierzat ciezarnych mozna stosowac inne materjaly wyjsciowe, zawie¬ rajace hormon pecherzykowy, jak lozyska i inne narzady, materjal roslinny lub po¬ dobny wzglednie wyciagi, otrzymywane z tych materjalów.Ponadto stwierdzono, ze substancje hormonowa mozna oddzielic od nierozpu- szczonych skladników obojetnych, podda¬ jac obróbce wstepnej, to jest rozpuszcza¬ jac pozostalosc, otrzymana po destylacji z para wodna zawierajacego hormon materja- lu wyjsciowego wzglednie wyciagu, w nie- mie&zajacym sie z woda rozpuszczalniku, jako to: eterze, benzenie lub rozpuszczal¬ nikach podobnych, i wyciagajac otrzymany roztwór zapomoca roizftwoiru alkalicznego.Hoinmon wówczas jest zawarty w roztwo¬ rze alkalicznym.Przyklad. 500 g wyciagu z lozysk, o- trzymanego w1 zwykly sposób, wykazujace- sich, uwalnia sie od skladników lotnych, np. fenoli, przez destylacje z para wód- rfa. Pozostalosc gotuje sig W obecnosci za¬ sad przez kilka godzin, poczem przesacza, Do tego roztworu alkalicznego dodaje sie, mieszajac energicznie, 250 g chlorku ben- zoylowego. W cieczy osadza sie benzoesan hormonu pecherzykowego w postaci mazi; mozna go odsaczyc, dodajac ewentualnie .ziemi okrzemkowej. Produkt reakcji moz¬ na równiez *wtr«asac z •terem, praycrem benzoesan hormonu pecherzykowego prze¬ chodzi do eteru. Po odparowaniu eteru ben¬ zoesan ten pozostaje jako masa krysta¬ liczna. PLThe longest duration of the patent, until September 25, 1950, Patent No. 22,179 relates to a method of obtaining follicular hormone from urine and consists in the fact that the starting material, after appropriate pretreatment, is transferred to an alkaline solution, and subjected to the action of After acylation, the resulting acylation products were separated and saponified. It has now been found that instead of urine of relatively pregnant animals, other starting materials containing follicular hormone, such as bearings and other organs, plant material or vaginal fluid, can be used. The relatively similar extracts obtained from these materials. Moreover, it has been found that the hormone substance can be separated from the undissolved inert ingredients by pretreating, i.e. dissolving the residue obtained after distillation with steam of the hormone-containing starting material or extract in a neutral water-consuming solvent such as ether, benzene or similar solvents, and extract The solution obtained is in an alkaline solution. The hoinmon is then contained in the alkaline solution. 500 g of bearing extract, obtained in the usual way, showing its strength, is freed from volatile constituents, eg phenols, by steam distillation. The residue is boiled in the presence of the bases for several hours and then filtered. 250 g of benzoyl chloride are added to this alkaline solution with vigorous stirring. The bubble hormone benzoate is deposited in the liquid in the form of a fluid; you can drain it, possibly adding diatomaceous earth. The reaction product can also be added with ter, the prime of the bubble hormone benzoate passes to the ether. After evaporation of the ether, the benzoate remains as a crystalline mass. PL
Claims (2)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL23786B3 true PL23786B3 (en) | 1936-09-30 |
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