PL2254579T3 - Zastosowanie związków wiążących się do ligandów receptora sigma do leczenia bólu neuropatycznego powstającego w konsekwencji chemioterapii - Google Patents
Zastosowanie związków wiążących się do ligandów receptora sigma do leczenia bólu neuropatycznego powstającego w konsekwencji chemioterapiiInfo
- Publication number
- PL2254579T3 PL2254579T3 PL09712762T PL09712762T PL2254579T3 PL 2254579 T3 PL2254579 T3 PL 2254579T3 PL 09712762 T PL09712762 T PL 09712762T PL 09712762 T PL09712762 T PL 09712762T PL 2254579 T3 PL2254579 T3 PL 2254579T3
- Authority
- PL
- Poland
- Prior art keywords
- chemotherapy
- consequence
- treatment
- neuropathic pain
- receptor ligands
- Prior art date
Links
- 238000002512 chemotherapy Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 208000004296 neuralgia Diseases 0.000 title 1
- 208000021722 neuropathic pain Diseases 0.000 title 1
- 239000003982 sigma receptor ligand Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08384001A EP2090311A1 (en) | 2008-02-18 | 2008-02-18 | Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy |
| EP08008682 | 2008-05-08 | ||
| PCT/EP2009/001109 WO2009103487A1 (en) | 2008-02-18 | 2009-02-17 | Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy |
| EP09712762.5A EP2254579B1 (en) | 2008-02-18 | 2009-02-17 | Use of compounds binding to the sigma receptor ligands for the treatment of neuropathic pain developing as a consequence of chemotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2254579T3 true PL2254579T3 (pl) | 2018-08-31 |
Family
ID=40790823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL09712762T PL2254579T3 (pl) | 2008-02-18 | 2009-02-17 | Zastosowanie związków wiążących się do ligandów receptora sigma do leczenia bólu neuropatycznego powstającego w konsekwencji chemioterapii |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20110052723A1 (pl) |
| EP (1) | EP2254579B1 (pl) |
| JP (1) | JP5859207B2 (pl) |
| KR (1) | KR20110008166A (pl) |
| CN (1) | CN101951908A (pl) |
| AU (1) | AU2009217031B2 (pl) |
| BR (1) | BRPI0908217A2 (pl) |
| CA (1) | CA2712640A1 (pl) |
| DK (1) | DK2254579T3 (pl) |
| ES (1) | ES2665042T3 (pl) |
| HU (1) | HUE036546T2 (pl) |
| MX (1) | MX2010009026A (pl) |
| PL (1) | PL2254579T3 (pl) |
| PT (1) | PT2254579T (pl) |
| RU (1) | RU2537226C2 (pl) |
| WO (1) | WO2009103487A1 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| GB0907973D0 (en) * | 2009-05-08 | 2009-06-24 | Modern Biosciences Plc | Combination therapy |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2353598A1 (en) * | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| WO2012064150A2 (ko) * | 2010-11-11 | 2012-05-18 | 한국생명공학연구원 | 벤프로페린 유도체를 유효성분으로 함유하는 혈관신생-관련 질환의 예방 및 치료용 조성물 |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| US10709767B2 (en) * | 2012-05-31 | 2020-07-14 | Kinki University | Agent for prophylactic and/or therapeutic treatment of peripheral neuropathic pain caused by anticancer agent |
| RU2506077C1 (ru) * | 2013-01-25 | 2014-02-10 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Комбинация для профилактики, коррекции и терапии боли, связанной с нейродегенерацией или ассоциированной с соматоформными расстройствами |
| AU2014364647A1 (en) | 2013-12-17 | 2016-06-23 | Laboratorios Del Dr. Esteve, S.A. | Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) and Sigma receptor ligands combinations |
| WO2015134545A2 (en) * | 2014-03-04 | 2015-09-11 | The University Of Mississippi | Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and conitive disorders |
| WO2015135947A1 (en) * | 2014-03-10 | 2015-09-17 | Universite D'aix-Marseille | Piperazine phenothiazine derivatives for treating spasticity |
| EP2985036A3 (en) * | 2014-08-14 | 2016-03-09 | Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. | CYP2J2 antagonists in the treatment of pain |
| EP3777851B1 (en) | 2015-07-16 | 2022-12-28 | Xomics Biopharma, Inc. | Selective oct2 inhibitors for use in preventing toxicity of platinum drugs |
| EP3415143A1 (en) | 2017-06-16 | 2018-12-19 | Kai-Uwe Kern | Bromhexine for the treatment of pain |
| WO2019126739A1 (en) | 2017-12-21 | 2019-06-27 | Shepherd Therapeutics, Inc. | Pyrvinium pamoate anti-cancer therapies |
| US11497795B2 (en) | 2018-09-28 | 2022-11-15 | Asahi Kasei Pharma Corporation | Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent |
| KR20200046525A (ko) * | 2018-10-24 | 2020-05-07 | 건국대학교 글로컬산학협력단 | 피렌페론 화합물을 유효성분으로 포함하는 취약 x 증후군 및 관련 발달 장애치료용 조성물 |
| CN116615242A (zh) * | 2021-03-04 | 2023-08-18 | 寿协株式会社 | 癌症治疗药 |
| CA3251657A1 (en) * | 2022-05-02 | 2023-11-09 | Undaunted Bio, Inc. | Trimeprazine is intended for use in the treatment of trigeminal neuralgia and to reduce the pain associated with it. |
| US20250134903A1 (en) * | 2023-11-01 | 2025-05-01 | Undaunted Bio, Inc. | Compositions and methods for treating pain |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69838421D1 (en) * | 1997-07-02 | 2007-10-25 | Merck & Co Inc | Polymorphe form des tachykininrezeptorantagonisten 2-(r)-(1-(r)-(3,5-bis(trifluormethyl)phenyl)ethoxy)-3-(s)-(4-fluor)phenyl-4-(3-5-oxo-1h,4h-1,2,4-triazolo)methylmorpholin |
| RU2218187C2 (ru) * | 2002-02-11 | 2003-12-10 | Ростовский научно-исследовательский онкологический институт | Способ лечения болевого синдрома у онкологических больных |
| GB0206505D0 (en) * | 2002-03-19 | 2002-05-01 | Euro Celtique Sa | Pharmaceutical combination |
| WO2004110387A2 (en) * | 2003-06-12 | 2004-12-23 | Agy Therapeutics, Inc. | Sigma ligands for neuronal regeneration and functional recovery |
| WO2006010587A1 (en) | 2004-07-24 | 2006-02-02 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds active on the sigma receptor for the treatment of mechanical allodynia |
| US7696199B2 (en) * | 2004-08-27 | 2010-04-13 | Laboratorios Del Dr. Esteve, S.A. | Sigma receptor inhibitors |
| US20090325975A1 (en) | 2005-07-15 | 2009-12-31 | Helmut H Buschmann | Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain |
| EP1761071A1 (de) * | 2005-08-29 | 2007-03-07 | Stueckler Gerd | Verfahren zur Aufnahme eines Bildes und Digitalkamera |
| EP2394646B1 (en) * | 2006-03-27 | 2018-07-25 | Wex Medical Limited | Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy |
-
2009
- 2009-02-17 ES ES09712762.5T patent/ES2665042T3/es active Active
- 2009-02-17 WO PCT/EP2009/001109 patent/WO2009103487A1/en not_active Ceased
- 2009-02-17 DK DK09712762.5T patent/DK2254579T3/en active
- 2009-02-17 RU RU2010138634/15A patent/RU2537226C2/ru not_active IP Right Cessation
- 2009-02-17 KR KR1020107020880A patent/KR20110008166A/ko not_active Ceased
- 2009-02-17 PL PL09712762T patent/PL2254579T3/pl unknown
- 2009-02-17 CN CN2009801055066A patent/CN101951908A/zh active Pending
- 2009-02-17 MX MX2010009026A patent/MX2010009026A/es active IP Right Grant
- 2009-02-17 PT PT97127625T patent/PT2254579T/pt unknown
- 2009-02-17 JP JP2010546270A patent/JP5859207B2/ja not_active Expired - Fee Related
- 2009-02-17 HU HUE09712762A patent/HUE036546T2/hu unknown
- 2009-02-17 CA CA2712640A patent/CA2712640A1/en not_active Abandoned
- 2009-02-17 EP EP09712762.5A patent/EP2254579B1/en not_active Not-in-force
- 2009-02-17 BR BRPI0908217-4A patent/BRPI0908217A2/pt not_active IP Right Cessation
- 2009-02-17 US US12/735,824 patent/US20110052723A1/en not_active Abandoned
- 2009-02-17 AU AU2009217031A patent/AU2009217031B2/en not_active Ceased
-
2017
- 2017-01-10 US US15/402,867 patent/US20170112829A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2665042T3 (es) | 2018-04-24 |
| DK2254579T3 (en) | 2018-04-09 |
| EP2254579B1 (en) | 2018-01-10 |
| JP5859207B2 (ja) | 2016-02-10 |
| US20170112829A1 (en) | 2017-04-27 |
| RU2010138634A (ru) | 2012-03-27 |
| PT2254579T (pt) | 2018-04-16 |
| CN101951908A (zh) | 2011-01-19 |
| EP2254579A1 (en) | 2010-12-01 |
| JP2011512338A (ja) | 2011-04-21 |
| US20110052723A1 (en) | 2011-03-03 |
| BRPI0908217A2 (pt) | 2015-08-25 |
| MX2010009026A (es) | 2010-09-24 |
| WO2009103487A1 (en) | 2009-08-27 |
| AU2009217031A1 (en) | 2009-08-27 |
| KR20110008166A (ko) | 2011-01-26 |
| HUE036546T2 (hu) | 2018-07-30 |
| AU2009217031B2 (en) | 2013-12-19 |
| RU2537226C2 (ru) | 2014-12-27 |
| CA2712640A1 (en) | 2009-08-27 |
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