PL2240442T3 - Sposób wytwarzania przydatny w syntezie atorwastatyny - Google Patents
Sposób wytwarzania przydatny w syntezie atorwastatynyInfo
- Publication number
- PL2240442T3 PL2240442T3 PL08741152T PL08741152T PL2240442T3 PL 2240442 T3 PL2240442 T3 PL 2240442T3 PL 08741152 T PL08741152 T PL 08741152T PL 08741152 T PL08741152 T PL 08741152T PL 2240442 T3 PL2240442 T3 PL 2240442T3
- Authority
- PL
- Poland
- Prior art keywords
- atorvastatin
- synthesis
- preparation process
- process useful
- useful
- Prior art date
Links
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title 1
- 229960005370 atorvastatin Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020080000083A KR100850558B1 (ko) | 2008-01-02 | 2008-01-02 | 아토르바스타틴의 효율적인 제조방법 |
| EP08741152A EP2240442B1 (en) | 2008-01-02 | 2008-04-04 | Preparation process useful in synthesis of atorvastatin |
| PCT/KR2008/001902 WO2009084773A2 (en) | 2008-01-02 | 2008-04-04 | Preparation process useful in synthesis of atorvastatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2240442T3 true PL2240442T3 (pl) | 2012-11-30 |
Family
ID=39881235
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08741152T PL2240442T3 (pl) | 2008-01-02 | 2008-04-04 | Sposób wytwarzania przydatny w syntezie atorwastatyny |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8124790B2 (pl) |
| EP (1) | EP2240442B1 (pl) |
| JP (1) | JP2011515328A (pl) |
| KR (1) | KR100850558B1 (pl) |
| PL (1) | PL2240442T3 (pl) |
| WO (1) | WO2009084773A2 (pl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112851504B (zh) * | 2021-02-09 | 2022-10-14 | 山东艾孚特科技有限公司 | 一种异丁酰乙酸甲酯的合成方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4681893A (en) * | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
| US5003080A (en) * | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
| US5216174A (en) * | 1988-02-22 | 1993-06-01 | Warner-Lambert Co. | Process for trans-6-[12-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5124482A (en) * | 1988-02-22 | 1992-06-23 | Warner-Lambert Company | Process for trans-6-(2-substituted-pyrrol-1-yl)alkyl)pyran-2-one inhibitors of cholesterol synthesis |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| WO1998004543A1 (en) | 1996-07-29 | 1998-02-05 | Warner-Lambert Company | Improved process for the synthesis of protected esters of (s)-3,4-dihydroxybutyric acid |
| WO2002057229A1 (en) * | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
| EP1480943A2 (en) | 2002-11-15 | 2004-12-01 | Teva Pharmaceutical Industries Limited | Synthesis of 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids |
| AU2004317570B2 (en) * | 2004-03-17 | 2011-01-06 | Ranbaxy Laboratories Limited | Process for the production of atorvastatin calcium in amorphous form |
| CN1980890A (zh) * | 2004-05-31 | 2007-06-13 | 兰贝克赛实验室有限公司 | 阿托伐他汀的制备方法 |
| WO2006110918A1 (en) | 2005-04-13 | 2006-10-19 | Ambit Biosciences Corporation | Pyrrole compounds and uses thereof |
| ATE432276T1 (de) | 2005-09-09 | 2009-06-15 | Pfizer Science & Tech Ltd | Herstellung eines atorvastatin-zwischenprodukts |
| KR20080000083A (ko) * | 2006-06-26 | 2008-01-02 | 엘지.필립스 엘시디 주식회사 | 액정표시소자의 제조방법 |
-
2008
- 2008-01-02 KR KR1020080000083A patent/KR100850558B1/ko not_active Expired - Fee Related
- 2008-04-04 JP JP2010535864A patent/JP2011515328A/ja active Pending
- 2008-04-04 PL PL08741152T patent/PL2240442T3/pl unknown
- 2008-04-04 WO PCT/KR2008/001902 patent/WO2009084773A2/en not_active Ceased
- 2008-04-04 EP EP08741152A patent/EP2240442B1/en not_active Not-in-force
- 2008-04-04 US US12/734,500 patent/US8124790B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009084773A2 (en) | 2009-07-09 |
| EP2240442B1 (en) | 2012-06-20 |
| WO2009084773A3 (en) | 2010-02-18 |
| US20110112309A1 (en) | 2011-05-12 |
| KR100850558B1 (ko) | 2008-08-06 |
| EP2240442A2 (en) | 2010-10-20 |
| JP2011515328A (ja) | 2011-05-19 |
| US8124790B2 (en) | 2012-02-28 |
| EP2240442A4 (en) | 2011-01-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL208328A0 (en) | Methods to produce strechable products | |
| ZA201102510B (en) | Slurry process for synthesis of biophosphites | |
| ZA201101836B (en) | Process for the preparation of rufinamide | |
| ZA200905335B (en) | Process for the synthesis of agomelatine | |
| IL208792A0 (en) | Process for the preparation of amides | |
| IL226244A (en) | Methods for the synthesis of amine thiazolopyridine-2-ylaoxy-phenyl and thiazolopyrazine-2-ylaoxy-phenyl | |
| ZA201100123B (en) | Bromine-facilitated synthesis of fluoro-sulfur compounds | |
| EP2212251A4 (en) | PROCESS FOR THE PRODUCTION OF CLUSTERBOR | |
| PL2279175T3 (pl) | Sposób wytwarzania związków pośrednich naftalen-2-ylopirazol-3-onu użytecznych w syntezie inhibitorów receptorów sigma | |
| GB0817926D0 (en) | Articles of clothiing | |
| EG26332A (en) | Process for the preparation of benzonoprons | |
| ZA200905051B (en) | Process for the synthesis of agomelatine | |
| GB0819537D0 (en) | Method of product authentification | |
| IL183445A0 (en) | Continuous process of preparing bromopicrin | |
| EP2205524A4 (en) | METHODS OF MANUFACTURING CLUSTER BORON | |
| EP2205525A4 (en) | PROCESS FOR THE PREPARATION OF CLUSTERBORON | |
| IL210106A0 (en) | Methods of synthesis of morphinans | |
| IL208918A0 (en) | Methods of preparing substituted heterocycles-149 | |
| EP2240442A4 (en) | FOR THE SYNTHESIS OF ATORVASTATIN SUITABLE PRODUCTION PROCESS | |
| GB0823366D0 (en) | Synthesis | |
| PL2896614T3 (pl) | Sposoby i związki do wytwarzania normorfinanów | |
| EP2331490A4 (en) | PREPARATION OF DIBUTOXYMETHANE | |
| SI2504309T1 (sl) | Sinteza acetokslacetaldehida | |
| IL198572A0 (en) | Process for the preparation of tigecycline in the amorphous form | |
| IL213110A0 (en) | Process for the preparation of tetrazine derivatives |