PL2064337T3 - Oparty na FACS i białku reporterowym układ do wysokowydajnego opracowywania białek terapeutycznych - Google Patents

Oparty na FACS i białku reporterowym układ do wysokowydajnego opracowywania białek terapeutycznych

Info

Publication number
PL2064337T3
PL2064337T3 PL07838397T PL07838397T PL2064337T3 PL 2064337 T3 PL2064337 T3 PL 2064337T3 PL 07838397 T PL07838397 T PL 07838397T PL 07838397 T PL07838397 T PL 07838397T PL 2064337 T3 PL2064337 T3 PL 2064337T3
Authority
PL
Poland
Prior art keywords
facs
based system
high throughput
therapeutic proteins
reporter protein
Prior art date
Application number
PL07838397T
Other languages
English (en)
Inventor
Christine Demaria
Scott Estes
Kenneth P Karey
Victor Cairns
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of PL2064337T3 publication Critical patent/PL2064337T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70592—CD52
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
PL07838397T 2006-09-20 2007-09-18 Oparty na FACS i białku reporterowym układ do wysokowydajnego opracowywania białek terapeutycznych PL2064337T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84622306P 2006-09-20 2006-09-20
US84770506P 2006-09-27 2006-09-27
PCT/US2007/020180 WO2008036255A2 (en) 2006-09-20 2007-09-18 A facs-and reporter protein-based system for high throughput development of therapeutic proteins
EP07838397A EP2064337B1 (en) 2006-09-20 2007-09-18 A facs-and reporter protein-based system for high throughput development of therapeutic proteins

Publications (1)

Publication Number Publication Date
PL2064337T3 true PL2064337T3 (pl) 2012-12-31

Family

ID=39201056

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07838397T PL2064337T3 (pl) 2006-09-20 2007-09-18 Oparty na FACS i białku reporterowym układ do wysokowydajnego opracowywania białek terapeutycznych

Country Status (7)

Country Link
US (1) US20090239235A1 (pl)
EP (1) EP2064337B1 (pl)
AR (1) AR062916A1 (pl)
ES (1) ES2388003T3 (pl)
PL (1) PL2064337T3 (pl)
PT (1) PT2064337E (pl)
WO (1) WO2008036255A2 (pl)

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EP2404869A1 (en) * 2010-07-06 2012-01-11 Ammonia Casale S.A. Process for producing ammonia synthesis gas
US8918181B2 (en) 2010-11-16 2014-12-23 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treatment of dry eye
US9821159B2 (en) 2010-11-16 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
WO2014165124A1 (en) 2013-03-12 2014-10-09 Oculeve, Inc. Implant delivery devices, systems, and methods
WO2014172693A2 (en) 2013-04-19 2014-10-23 Oculeve, Inc. Nasal stimulation devices and methods
AU2015223184B2 (en) 2014-02-25 2020-07-02 Oculeve, Inc. Polymer formulations for nasolacrimal stimulation
AU2015292278B2 (en) 2014-07-25 2020-04-09 Oculeve, Inc. Stimulation patterns for treating dry eye
WO2016065211A1 (en) 2014-10-22 2016-04-28 Oculeve, Inc. Contact lens for increasing tear production
MX2017005204A (es) 2014-10-22 2017-12-14 Oculeve Inc Dispositivos y métodos de estimulación para tratar el ojo seco.
CN107427601B (zh) 2015-03-27 2021-08-31 3M创新有限公司 纤维蛋白组合物、方法和伤口用制品
EP4530350A3 (en) * 2015-10-09 2025-06-25 Genzyme Corporation Improved flare (flow cytometry attenuated reporter expression) technology for rapid bulk sorting
US10426958B2 (en) 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
WO2017192572A1 (en) 2016-05-02 2017-11-09 Oculeve, Inc. Intranasal stimulation for treatment of meibomian gland disease and blepharitis
WO2018067622A1 (en) 2016-10-05 2018-04-12 3M Innovative Properties Company Fibrinogen composition, method and wound articles
US11827754B2 (en) 2016-10-05 2023-11-28 3M Innovative Properties Company Fibrin composition comprising carrier material, method and wound articles
SG11201903018WA (en) * 2016-10-07 2019-05-30 Genzyme Corp Early post-transfection isolation of cells (epic) for biologics production
JP2020500609A (ja) 2016-12-02 2020-01-16 オキュリーブ， インコーポレイテッド ドライアイ予測及び治療勧告のための装置及び方法
KR20230109683A (ko) 2020-11-19 2023-07-20 젠자임 코포레이션 유세포 분석 감쇠 리포터 발현(플레어) 다중 리포터 시스템 및 이의 사용 방법

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US4937190A (en) * 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
EP1012268A4 (en) * 1997-02-25 2001-11-28 Qbi Entpr Ltd IRES SEQUENCES WITH HIGH TRANSLATION EFFICIENCY AND EXPRESSION VECTORS CONTAINING THEM
GB9815909D0 (en) * 1998-07-21 1998-09-16 Btg Int Ltd Antibody preparation
WO2001057212A1 (en) * 2000-02-02 2001-08-09 Iconix Pharmaceuticals, Inc. Rapid, parallel identification of cell lines
US6833254B2 (en) * 2001-03-01 2004-12-21 The Regents Of The University Of California Method to identify IRES elements
DE10143237A1 (de) * 2001-09-04 2003-03-20 Icon Genetics Ag Herstellung künstlicher interner ribosomaler Eingangsstellenelemente (Ires-Elemente)
DE10143238A1 (de) * 2001-09-04 2003-03-20 Icon Genetics Ag Identifizierung eukaryotischer interner Ribosomen-Eingangsstellen (IRES)-Elemente
US7119187B2 (en) * 2002-07-09 2006-10-10 National Health Research Institutes Internal ribosome entry site of the labial gene for protein expression
EP3346010A1 (en) * 2003-06-24 2018-07-11 Genzyme Corporation Novel beta-actin and rps21 promoters and uses thereof
JP5291341B2 (ja) * 2004-11-08 2013-09-18 クロマジェニックス ベー ヴェー タンパク質を高レベルで発現する宿主細胞の選定
SI1809750T1 (sl) * 2004-11-08 2012-08-31 Chromagenics Bv Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina

Also Published As

Publication number Publication date
WO2008036255A3 (en) 2008-07-24
EP2064337B1 (en) 2012-07-18
PT2064337E (pt) 2012-07-26
US20090239235A1 (en) 2009-09-24
WO2008036255A2 (en) 2008-03-27
AR062916A1 (es) 2008-12-17
ES2388003T3 (es) 2012-10-05
EP2064337A2 (en) 2009-06-03

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