PL19498B3 - A method of producing homologs of iodomethylsulfonic acid and its salts. - Google Patents
A method of producing homologs of iodomethylsulfonic acid and its salts. Download PDFInfo
- Publication number
- PL19498B3 PL19498B3 PL19498A PL1949831A PL19498B3 PL 19498 B3 PL19498 B3 PL 19498B3 PL 19498 A PL19498 A PL 19498A PL 1949831 A PL1949831 A PL 1949831A PL 19498 B3 PL19498 B3 PL 19498B3
- Authority
- PL
- Poland
- Prior art keywords
- acid
- iodomethylsulfonic
- salts
- homologs
- producing
- Prior art date
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- 150000003839 salts Chemical class 0.000 title claims description 6
- RDFJFVXMRYVOAC-UHFFFAOYSA-N methiodal Chemical compound OS(=O)(=O)CI RDFJFVXMRYVOAC-UHFFFAOYSA-N 0.000 title claims description 5
- 238000000034 method Methods 0.000 title claims description 5
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical class I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 2
- 229940071870 hydroiodic acid Drugs 0.000 description 2
- 150000004694 iodide salts Chemical class 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- -1 amine salts Chemical class 0.000 description 1
- HMPHJJBZKIZRHG-UHFFFAOYSA-N chloromethanesulfonic acid Chemical compound OS(=O)(=O)CCl HMPHJJBZKIZRHG-UHFFFAOYSA-N 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- BTZNPZMHENLISZ-UHFFFAOYSA-N fluoromethanesulfonic acid Chemical compound OS(=O)(=O)CF BTZNPZMHENLISZ-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
Najdluzszy czas trwania patentu do 13 czerwca 1948 r.Patent Nr 18606 i jego patent dodat¬ kowy Nr 18992 chronia sposób wytwarza¬ nia kwasu jodometylosulfonowego, który polega na tern, ze kwas chlorometylosulfo- nowy, wzglednie bromo- lub fluorometylo- sulfonowy, doprowadza sie do reakcji po¬ dwójnej wymiany z jodkami potasowców lub wapniowców, wzglednie z innemi solami metalowemi lub aminowemi kwasu jodowo- dorowego, przyczem chlorowiec ulega wy¬ mianie na jod.Przy dalszem opracowaniu tego sposobu wykryto, ze mozna wytworzyc homologi kwasu jodometylosulfonowego sposobami wedlug patentów powyzszych, jesli dziala¬ niem soli kwasu jodowodorowego wyrrfienic chlorowiec na jod w homologach kwasów chlorowco-metylosulfonowych, wzglednie ich solach.Homologi kwasu jodometylosulfonowe¬ go, wzglednie jego sole, okazaly sie szcze¬ gólnie cennemi jako kontrastowe srodki rentgenowskie.Przyklad. 16,65 czesci wagowych a-chlo- roetylo-a-sulfonianu sodowego ogrzewa sie w naczyniu zamknietem z 16 czesciami wa- gowemi jodku sodowego w trzykrotnej ilo¬ sci wody w ciagu 8 godzin w temperaturze 180° -i- 190°. Mieszanine reakcyjna odpa¬ rowuje sie do sucha. Utworzona sól sodowakwasu u-jodoetylo-a-sulfonowego oczyszcza miast kwasów chlorowcomctylosulfono- sie zapomoca wielokrotnego przekrystalizo- wych, wzglednie ich soli, poddaje sie obrób- wywania z alkoholu. ce jodkami ich homologi. PLThe longest term of the patent, until June 13, 1948, Patent No. 18606 and its additional patent No. 18992 protect the method of producing iodomethylsulfonic acid, which consists in the fact that chloromethylsulfonic acid, or bromo- or fluoromethylsulfonic acid, is fed for the bi-exchange reaction with potassium or alkaline earth iodides, or with other metal or amine salts of hydroiodic acid, the halogen is exchanged into iodine. In further development of this method it was found that homologues of iodomethylsulfonic acid could be produced by methods according to the above patents If, by the action of the salt of hydroiodic acid, the halogen is converted to iodine in the halomethylsulfonic acid homologs or their salts, the homologues of iodomethylsulfonic acid, or its salts, have proved to be particularly valuable as X-ray contrast agents. 16.65 parts by weight of sodium α-chloroethyl α-sulphonate are heated in a sealed vessel with 16 parts by weight of sodium iodide in three times the amount of water for 8 hours at 180 ° -190 °. The reaction mixture is evaporated to dryness. The formed sodium salt of u-iodoethyl-a-sulfonic acid purifies instead of halomethylsulfonate by means of repeated recrystallization, or their salts, it is processed from alcohol. with iodides of their homologues. PL
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL19498B3 true PL19498B3 (en) | 1934-01-31 |
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