PL1716149T3 - Amorficzny kwas (6S)-folinowy do wytwarzania stabilnych wodnych roztworów (6S)-folinianu sodu lub potasu - Google Patents

Amorficzny kwas (6S)-folinowy do wytwarzania stabilnych wodnych roztworów (6S)-folinianu sodu lub potasu

Info

Publication number
PL1716149T3
PL1716149T3 PL05706514T PL05706514T PL1716149T3 PL 1716149 T3 PL1716149 T3 PL 1716149T3 PL 05706514 T PL05706514 T PL 05706514T PL 05706514 T PL05706514 T PL 05706514T PL 1716149 T3 PL1716149 T3 PL 1716149T3
Authority
PL
Poland
Prior art keywords
folinate
amorphous
potassium
sodium
aqueous solutions
Prior art date
Application number
PL05706514T
Other languages
English (en)
Inventor
Francese Giancarlo
Moreno Morosoli
Original Assignee
Cerbios Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cerbios Pharma Sa filed Critical Cerbios Pharma Sa
Publication of PL1716149T3 publication Critical patent/PL1716149T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL05706514T 2004-02-20 2005-02-18 Amorficzny kwas (6S)-folinowy do wytwarzania stabilnych wodnych roztworów (6S)-folinianu sodu lub potasu PL1716149T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH00285/04A CH696717A5 (de) 2004-02-20 2004-02-20 Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
EP05706514A EP1716149B1 (de) 2004-02-20 2005-02-18 Amorphe (6S)-Folinsäure zur Herstellung von stabilen wässrigen Lösungen von Natrium- oder Kalium (6S)-Folinat
PCT/CH2005/000092 WO2005080395A2 (de) 2004-02-20 2005-02-18 Verfahren zur herstellung von kristalliner (6rs)-n(5)-formyl-5,6,7,8-tetrahydrofolsäure

Publications (1)

Publication Number Publication Date
PL1716149T3 true PL1716149T3 (pl) 2013-05-31

Family

ID=34866025

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05706514T PL1716149T3 (pl) 2004-02-20 2005-02-18 Amorficzny kwas (6S)-folinowy do wytwarzania stabilnych wodnych roztworów (6S)-folinianu sodu lub potasu

Country Status (10)

Country Link
US (1) US20080153849A1 (pl)
EP (1) EP1716149B1 (pl)
JP (1) JP2007523095A (pl)
AU (1) AU2005215845B8 (pl)
CA (1) CA2554024C (pl)
CH (1) CH696717A5 (pl)
ES (1) ES2267421T3 (pl)
PL (1) PL1716149T3 (pl)
PT (1) PT1716149E (pl)
WO (1) WO2005080395A2 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1748704B (zh) * 2004-09-15 2011-05-04 尼普洛株式会社 注射用水溶液制剂及其稳定化方法
US20100047314A1 (en) * 2008-08-22 2010-02-25 Osteogenex Inc. Folinic acid derivatives for promoting bone growth
EP2502625A1 (en) 2011-03-21 2012-09-26 GMT Fine Chemicals SA Process for the preparation of crystalline levofolinic acid
CN111138434A (zh) * 2019-09-18 2020-05-12 南京海纳医药科技股份有限公司 一种左亚叶酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
CH673459A5 (pl) * 1987-05-15 1990-03-15 Eprova Ag
NL8901432A (nl) * 1989-06-06 1991-01-02 Pharmachemie Bv Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.
CH681303A5 (pl) * 1991-01-16 1993-02-26 Eprova Ag
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
CH687062A5 (de) * 1994-02-14 1996-09-13 Cerbios Pharma Sa Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl) * 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.

Also Published As

Publication number Publication date
AU2005215845B2 (en) 2008-08-14
AU2005215845B8 (en) 2008-08-28
CH696717A5 (de) 2007-10-31
WO2005080395A3 (de) 2006-02-16
ES2267421T1 (es) 2007-03-16
CA2554024A1 (en) 2005-09-01
US20080153849A1 (en) 2008-06-26
PT1716149E (pt) 2013-03-04
ES2267421T3 (es) 2013-04-16
WO2005080395A2 (de) 2005-09-01
CA2554024C (en) 2011-12-13
AU2005215845A1 (en) 2005-09-01
EP1716149A2 (de) 2006-11-02
JP2007523095A (ja) 2007-08-16
EP1716149B1 (de) 2012-12-12

Similar Documents

Publication Publication Date Title
IL226395A0 (en) A process for producing an aqueous chlorine solution for use as a bactericide
ZA200707652B (en) Aqueous solutions of optical brighteners
PH12014502593A1 (en) Crystalline forms of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl]-1-methyl-urea and salts thereof
GB0503533D0 (en) Evaporate for dilute aqueous solutions
EP1928413A4 (en) AQUEOUS FORMULATION OF hFSH
HK1156311A1 (en) Preparation of pyridonecarboxylic acid antibacterials
IL183591A0 (en) Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
GB0624963D0 (en) Derivatives of 188-Glycyrrhetinic Acid
AU2003209043A1 (en) Novel anhydrous amorphous forms of montelukast sodium salt
PL1937407T3 (pl) Roztwory bezwodnych soli lantanowców i ich otrzymywanie
EP1808412A4 (en) PROCESS FOR PURIFYING AQUEOUS CALINE SOLUTION
HK1073102A1 (en) Sulphonic acid salts of mandelic acid derivatives
EP2114140A4 (en) SALT, AQUEOUS LIQUID COMPOSITION WITH SALTS OF S - (+) - ABSCISINIC ACID AND METHOD FOR THE PRODUCTION THEREOF
PL1716149T3 (pl) Amorficzny kwas (6S)-folinowy do wytwarzania stabilnych wodnych roztworów (6S)-folinianu sodu lub potasu
EP1961751A4 (en) ACIDIC ACID SALT OF AN OPTICALLY ACTIVE DIHYDROPYRIDINE DERIVATIVE
EP2001856A4 (en) CRYSTALLINE FORMS OF N- {2-TERT-BUTYL-1 - [(4,4-DIFLUOROCYCLOHEXYL) METHYL] -1H-BENZIMIDAZOL-5-YL} ETHANESULFONAMIDE SALTS
GB2439472B (en) Process for the solidification and stabilization of concentrated aqueous sodium hydroxide solution
EP1886682A4 (en) PROCESS FOR THE PREPARATION OF AQUEOUS SOLUTION OF DORIPENEM
EP1831171A4 (en) PROCESS FOR THE PREPARATION OF NEW MONTELUKAST SODIUM AMORPHOUS
EP2319514A4 (en) STABLE AQUEOUS SOLUTION COMPOSITION COMPRISING A SULFONAMIDE COMPOUND
HK1144192A1 (en) Stable crystalline salt of (r)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester (r)-3--345- 1-[222]
ZA200805701B (en) Salts of styphnic acid
IL187660A0 (en) Process for the preparation of sulfonic acid salts of oxabispidines
EP1915995A4 (en) AQUEOUS SOLUTION PREPARATION CONTAINING CAMPTOTHECINES
HK1135676A1 (en) Methods for purifying an aqueous hydrochloric acid solution