PL171521B1 - Method of obtaining a novel fungicidal preparation and novel fungicidal preparation as such - Google Patents

Abstract

1. A method of producing a new fungicide which contains furanocoumarins, characteristic in that the array of furanocoumarins extracted from a plant material, particularly from Archangelica officinalis Hoffm or Heracelum sosnowskyi Manden and/or single furanocoumarins are dissolved in vegetable oil until the concentration of 0.05-10 parts by weight of furanocoumarins per 100 parts by weight of the solution is obtained, and the product is mixed with vaseline and/or eucerinum and/or lanolin and/or glycerol monostearate in the amount of 1-9 parts by weight of the oil solution, and preferably with aromas. 2. A method of producing a new fungicide which contains furanocoumarins, characteristic in that the array of furanocoumarins and/or single furanocoumarins extracted from a plant material, particularly from Archangelica officinalis Hoffm or Heracelum sosnowskyi Manden and/or single furanocoumarins, are mulled with a solid base in the form of an animal fat and/or vaseline and/or lanolin and/or eucerinum and/or glycerol monostearate in the following weight proportions: 0.05-10 parts of furanocoumarins and 80-99.5 parts of the base, preferably at 18-50 degrees C. Further, the following substances are added in portions to the mixture: vegetable oil and/or animal fat and/or mineral oil in the amount of 10-50 parts by weight, and preferably 0.05-20 parts by weight of Evening Primrose oil, and 0.01-0.05 parts by weight of aromas preferably in the form of perfume oils. 3. A new fungicide based on furanocoumarins, characteristic in that the array of furanocoumarins and single furanocoumarins extracted from a plant material, particularly from fruits of Archangelica officinalis Hoffm or Heracelum sosnowskyi Manden dissolved in a vegetable oil and/or animal fat and/or mineral oil, and an ointment base containing vaseline and/or eucerinum and/or glycerol monostearate and/or animal fat, preferably lanolin, and preferably containing Evening Primrose oil, in the following weight proportions: an array of furanocoumarins and/or single furanocoumarins - 0.05-10 parts by weight; vegetable oil and/or animal fat and/or mineral oil - 30-50 parts by weight; Evening Primrose oil - 0.05-20 parts by weight; an ointment base containing vaseline and/or eucerinum and/or glycerol monostearate and/or animal fat - 20-70 parts by weight; aromas, preferably perfume oils - 0.01-0.05 parts by weight.

Description

The subject of the invention is a method of obtaining a new fungicidal preparation and a new fungicidal preparation intended, in particular, for the treatment of nail and skin mycoses.

Contrary to the treatment of bacterial and viral infections, where significant progress is noticeable in the production of new generations of drugs and preparations, the treatment of mycoses is based on a relatively small amount of active substances effective against pathogenic fungal strains. Therefore, new effective drugs that act against pathogenic fungi are constantly being sought. Mycoses are social diseases that require long-term treatment. The causes of mycoses are, among others, intoxication of the environment, infection after treatment with antibiotics and lowering the body's natural immunity.

171 521

Synthetic drugs are relatively the most effective antifungal drugs. The most recent of this group include triazole compounds, including fuconazole, all yamin derivatives (naphthitin and terbinafine). As antifungal agents, iodine tinctures, precipitated sulfur, sodium thiosulfate, salicylic acid, boric acid and others are also used.

The use of synthetic drugs is often associated with a strong side effect, drug resistance and allergies. Drugs of natural origin, as a rule, have a lower biological activity, but do not show negative side effects and do not cause drug resistance in pathogenic strains.

It is known from the literature that some furanocoumarins have fungicidal and fungistatic effects (Alderson T, Scott B.R. Mutat. Res 9, 569, 1970).

The basic problem in the use of preparations containing furanocoumarins is their poor solubility in polar solvents and common ointment bases.

The invention solves the problem of obtaining new fungicidal preparations that are highly soluble in polar solvents and in typical ointment bases.

Surprisingly, it has been found that the use of natural oils of vegetable origin or animal fats containing glycerides of higher fatty acids for the dissolution of biologically active furanocoumarins, or of paraffinic-type mineral oils, such as paraffin oil, petroleum jelly and glycerol monostearate or their mixtures, ensures their good solubility.

The method of obtaining the new fungicidal preparation according to the invention consists in dissolving the furanocoumarin complex isolated from plant material, especially from angelica (Archangelica off Hoffm) or pine borscht (Heracelum sosnowskyi Manden) and / or individual furanocoumarins are dissolved in vegetable oil to a concentration of 0 , 05-10 parts by weight of furanocoumarins per 100 parts by weight of the solution, and then the obtained product is mixed with petroleum jelly and / or eucerin and / or lanolin and / or glycerol monostearate in an amount of 1-9 parts by weight per 1 part of the oil solution and preferably with the agents fragrances.

Alternatively, a fungicidal preparation according to the invention is obtained in that a complex of furanocoumarins and / or individual furanocoumarins isolated from plant material, in particular from angelica (Archangelica off Hoffm) or pine borscht (Heracelum sosnowskyi Manden) are rubbed with a solid substrate which is animal fat and / or petroleum jelly and / or lanolin and / or eucerin and / or glycerol monostearate in a proportion of 0.05-10 parts by weight furanocoumarin to 80-99.5 parts by weight of a solid base, preferably at a temperature of 18-50 ° C, after whereby vegetable oil and / or animal oil and / or mineral oil are added portionwise to the mixture in an amount of 10-50 parts by weight, based on the total weight, and preferably evening primrose oil in an amount of 0.05-20 parts by weight.

The invention further relates to a new fungicidal preparation.

The fungicidal preparation according to the invention comprises a complex of furanocoumarins and / or some of them isolated from plant material, in particular from angelica or pine borscht, dissolved in vegetable oil and / or mineral oil and / or animal fat mixed with a solid base which is petroleum jelly and / or eucerin and / or glycerol monosterate and / or animal fat, preferably with the addition of evening primrose oil and flavors, preferably essential oils such as e.g. eucalyptus, in the amounts by weight:

- furanocoumarin complex and / or single furanocoumarins - 0.05-10 parts

- vegetable oil and / or animal fat and / or mineral oil - 30-50 parts

- evening primrose oil - 0.05-20 parts

- ointment base which is petroleum jelly and / or eucerin and / or glycerol nionosterarin and / or animal fat - 27-7c honor

- fragrances - 0.01-0.05 parts

The fungicidal preparation according to the invention contains furanocumerins with concentrations allowing for effective treatment of onychomycosis of the skin, and the described solvents and ointment bases allow for obtaining concentrations of coumarin preparations exceeding the concentration of

171 521 homicidal (in vitro determined). The compositions and prescription compositions facilitate the penetration of the biologically active substance into the skin.

Example 1 100 g of linseed oil was mixed with a complex of furanocoumarins with the composition: 700 mg of imperatorin, 200 mg of bergoptene, 90 mg of xanthotoxin, 7 mg of isopimpinelin, 3 mg of pimpinelin. The mixture was heated in a water bath to 35 ° C and stirred until the furanocoumarins were completely dissolved. The obtained clear yellow solution was then mixed with lanolin in a weight ratio of 1: 1. The mixture was rubbed for 15 minutes. A uniform light mass was obtained.

Example n. A solution of furanocoumarins in linseed oil obtained as in Example 1 was mixed with petroleum jelly and evening primrose oil in a weight ratio of 30:60:10. A uniform light yellow mass was obtained. Then 1% of chamomile oil was added to the mixture.

Example III. 1 g of pure imperatorin was ground with 50 g of glycerol monosterarate, adding 40 g of linseed oil, and then 10 g of evening primrose oil. A homogeneous mass of yellow color was obtained.

Example IV. 50 g of pork lard was heated in a water bath to 50 ° C, and then 1 g of pure bergapten, 40 g of paraffin oil, 3 g of eucerin and 5 g of evening primrose oil were added, mixing the ingredients intensively. A uniform light yellow mass was obtained after cooling.

Publishing Department of the UP RP. Circulation of 90 copies. Price PLN 2.00

Claims (3)

Patent claims 1. A method of obtaining a new fungicidal preparation containing furanocoumarins, characterized in that the furanocoumarin complex isolated from plant material, especially from angelica (Archangelica off Hoffm) or pine borscht (Heracelum sosnowskyi Manden) and / or individual furanocoumarins, is dissolved in vegetable oil to obtain a concentration of 0.05-10 parts by weight of furanocoumarins per 100 parts by weight of the solution, and then the obtained product is mixed with petroleum jelly and / or eucerin and / or lanolin and / or glycerol monostearate in the amount of 1-9 parts by weight per 1 part of the oil solution and preferably with fragrances. The method of obtaining a new fungicidal preparation containing furanocoumarins, characterized in that the complex of furanocoumarins and / or individual furanocoumarins isolated from plant material, especially from angelica (Archangelica off Hoffm) or pine borscht (Heracelum sosnowskyi Manden), is grinded with a solid substrate which is animal fat and / or petroleum jelly and / or lanolin and / or eucerin and / or glycerol monostearate in the proportions by weight: 0.05-10 parts of fyranocoumarins and 80-99.5 parts of vehicle, preferably at a temperature of 18-50 ° C, then vegetable oil and / or animal fat and / or mineral oil are added in portions to the mixture in an amount of 10-50 parts by weight, and preferably evening primrose oil in an amount of 0.05-20 parts and perfumes in an amount of 0.01-0.05 parts, essential oils are preferably used as fragrances. 3. A new fungicidal preparation based on furanocoumarins, characterized in that it contains a complex of furanocoumarins or individual furanocoumarins, isolated from plant material, especially from angelica fruit (Archangelica off Hoffm) or pine borscht (Heracleum sosnowskyi Manden), dissolved in vegetable oil and / or animal fat and / or mineral oil and an ointment base containing petrolatum and / or eucerin and / or glycerol monostearate and / or animal fat, preferably lanolin or preferably evening primrose oil in the amounts by weight: - furanocoumarin syndrome and / or furaaokumaryaz drugs - vegetable oil and / or animal and / or mineral fat - evening primrose oil - ointment base which is petroleum jelly and / or eucerin and / or glycerol moaaaging and / or animal fat fragrances, preferably essential oils 0.05-parts 30-50 parts 0.05-20 parts 20-70 parts 0.01-0.05 parts