PL146831B1 - Method of obtaining novel alpha-/10-oxy-4h-benzo-/4,5/-cyclohapta/1,2-b/thiophen-4-ylidene/-carboxylic acids - Google Patents

Method of obtaining novel alpha-/10-oxy-4h-benzo-/4,5/-cyclohapta/1,2-b/thiophen-4-ylidene/-carboxylic acids Download PDF

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Publication number
PL146831B1
PL146831B1 PL24998084A PL24998084A PL146831B1 PL 146831 B1 PL146831 B1 PL 146831B1 PL 24998084 A PL24998084 A PL 24998084A PL 24998084 A PL24998084 A PL 24998084A PL 146831 B1 PL146831 B1 PL 146831B1
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Poland
Prior art keywords
ylidene
benzo
oxy
formula
thiophen
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PL24998084A
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Polish (pl)
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PL249980A1 (en
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Sandoz Ag
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Priority to PL24998084A priority Critical patent/PL146831B1/en
Publication of PL249980A1 publication Critical patent/PL249980A1/en
Publication of PL146831B1 publication Critical patent/PL146831B1/en

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Claims (2)

Zastrzezenia patentowe 1. Sposób wytwarzania nowych kwasów c£ -/10-oksy-4H-benzo/4,57cyklohepta/l,2-b7tiofen- -4-ylideno/-karboksylowych o wzorze 1, w którym R. oznacza atom wodoru lub rodnik C,. *-al- kilowy ewentualnie podstawiony rodnikiem fenylowym, Rp oznacza atom wodoru, a pierscien A jest niepodstawiony albo podstawiony ohlorowcem lub grupami hydroksylowymi, albo ich soli, znamienny tym, ze hydrolizuje sie ester kwasu c< -/10-oksy-4H-benzo/4,5/ cyklo- hepta/l,2-b7tiofen-4-ylideno/-karboksylowego o wzorze 1a, w którym R,. i R- maja znaczenie wyzej podane, a R* oznacza rodnik C^ .-alkilowy, po czym otrzymany kwas o<*_/io-oksy-4H-ben- zoAt57cyklohepta/l,2-b7-tiofen-4-ylideno/-karboksylowy o wzorze 1 wyodrebnia sie w postaci wolnej lub w postaci soli.Claims 1. Process for the preparation of new c6- (10-oxy-4H-benzo (4,57cyclohepta) 1,2-b7thiophen-4-ylidene) -carboxylic acids of formula 1, in which R. is a hydrogen atom or a radical C ,. * -alkyl optionally substituted with a phenyl radical, Rp is a hydrogen atom and ring A is unsubstituted or substituted by halogen or hydroxyl groups or their salts, characterized by the hydrolysis of the ester of the acid c? - / 10-oxy-4H-benzo (4,5) cyclohepta (1,2-b7thiophen-4-ylidene) -carboxylic acid of the formula la, wherein R i. and R- are as defined above, and R * is a C 1-6 -alkyl radical, then the obtained acid is <*> 10-oxy-4H-benzoAt57cyclohepta (1,2-b7-thiophen-4-ylidene) The carboxylic acid of formula I is isolated in free or salt form. 2. Sposób wedlug zastrz. 1, znamienny tym, ze hydrolizuje sie zwiazek o wzorze 1a, w którym R^ oznacza rodnik metylowy, R^ oznacza atom wodoru, a R, oznacza rod¬ nik C^-alkilowy i wyodrebnia sie otrzymany kwas /"lO-metoksy-4K-benzo/4f5/cyklohepta /i,2-b7tiofen-4-ylideno7-octowy w postaci wolnej lub w postaci soli.146 831 CR, HOOC WZOR1" CR, COOR, WZÓR 1a WZOR1" Pracownia Poligraficzna UP PRL. Naklad 100 egz. Cena 400 zl PL2. The method according to claim A compound according to claim 1, characterized in that a compound of formula 1a is hydrolyzed, in which R 2 is a methyl radical, R 2 is a hydrogen atom and R 1 is a C 1-4 alkyl radical and the obtained acid ("10-methoxy-4K) is isolated. -benzo / 4f5 / cyclohepta / i, 2-b7thiophene-4-ylidene-7-acetic in free form or in the form of salt.146 831 CR, HOOC WZOR1 "CR, COOR, WZÓR 1a WZOR1" Pracownia Poligraficzna UP PRL. Circulation 100 copies. Price PLN 400 PL
PL24998084A 1984-10-11 1984-10-11 Method of obtaining novel alpha-/10-oxy-4h-benzo-/4,5/-cyclohapta/1,2-b/thiophen-4-ylidene/-carboxylic acids PL146831B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL24998084A PL146831B1 (en) 1984-10-11 1984-10-11 Method of obtaining novel alpha-/10-oxy-4h-benzo-/4,5/-cyclohapta/1,2-b/thiophen-4-ylidene/-carboxylic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL24998084A PL146831B1 (en) 1984-10-11 1984-10-11 Method of obtaining novel alpha-/10-oxy-4h-benzo-/4,5/-cyclohapta/1,2-b/thiophen-4-ylidene/-carboxylic acids

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PL249980A1 PL249980A1 (en) 1986-08-26
PL146831B1 true PL146831B1 (en) 1989-03-31

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PL249980A1 (en) 1986-08-26

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