PL140583B1 - Process for manufacturing novel acylo-gamma-butyrolactones - Google Patents

Process for manufacturing novel acylo-gamma-butyrolactones

Info

Publication number
PL140583B1
PL140583B1 PL1984252289A PL25228984A PL140583B1 PL 140583 B1 PL140583 B1 PL 140583B1 PL 1984252289 A PL1984252289 A PL 1984252289A PL 25228984 A PL25228984 A PL 25228984A PL 140583 B1 PL140583 B1 PL 140583B1
Authority
PL
Poland
Prior art keywords
formula
group
carbon atoms
carbonyl
radical
Prior art date
Application number
PL1984252289A
Other languages
English (en)
Polish (pl)
Other versions
PL252289A1 (en
Original Assignee
Cassella Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19833322079 external-priority patent/DE3322079A1/de
Priority claimed from DE19843411850 external-priority patent/DE3411850A1/de
Application filed by Cassella Ag filed Critical Cassella Ag
Publication of PL252289A1 publication Critical patent/PL252289A1/xx
Publication of PL140583B1 publication Critical patent/PL140583B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL1984252289A 1983-06-20 1984-06-19 Process for manufacturing novel acylo-gamma-butyrolactones PL140583B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833322079 DE3322079A1 (de) 1983-06-20 1983-06-20 Tetrahydropyridazinonderivate, verfahren zu ihrer herstellung und ihre verwendung
DE19843411850 DE3411850A1 (de) 1984-03-30 1984-03-30 Tetrahydropyridazinone, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
PL252289A1 PL252289A1 (en) 1985-08-13
PL140583B1 true PL140583B1 (en) 1987-05-30

Family

ID=25811589

Family Applications (2)

Application Number Title Priority Date Filing Date
PL1984252289A PL140583B1 (en) 1983-06-20 1984-06-19 Process for manufacturing novel acylo-gamma-butyrolactones
PL24828584A PL248285A1 (en) 1983-06-20 1984-06-19 Process for preparing novel derivatives of tetrahydropyridazinone

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL24828584A PL248285A1 (en) 1983-06-20 1984-06-19 Process for preparing novel derivatives of tetrahydropyridazinone

Country Status (15)

Country Link
US (1) US4666902A (enExample)
EP (1) EP0129791A3 (enExample)
KR (1) KR850000431A (enExample)
AU (1) AU2951884A (enExample)
DD (1) DD223449A5 (enExample)
DK (1) DK298984A (enExample)
ES (1) ES8503339A1 (enExample)
FI (1) FI842459A7 (enExample)
GR (1) GR82281B (enExample)
HU (1) HUT34961A (enExample)
IL (1) IL72151A (enExample)
NO (1) NO842486L (enExample)
PH (1) PH21286A (enExample)
PL (2) PL140583B1 (enExample)
PT (1) PT78757B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6153270A (ja) * 1984-08-17 1986-03-17 チバ・ガイギー・アクチエンゲゼルシヤフト 置換ピリダジノン、その製造方法及び該化合物を含む医薬製剤
US4816454A (en) * 1984-09-21 1989-03-28 Cassella Aktiengesellschaft 4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
DE3531658A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
HU195645B (en) * 1985-10-30 1988-06-28 Gyogyszerkutato Intezet Process for preparing novel 3(2h)-pyridazinone derivatives and pharmaceutical compositions comprising the same
GB8603780D0 (en) * 1986-02-15 1986-03-19 Smith Kline French Lab Chemical compounds
DE3804490A1 (de) * 1988-02-12 1989-08-24 Heumann Pharma Gmbh & Co Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JP2717687B2 (ja) * 1988-02-13 1998-02-18 日本曹達株式会社 ピリダジノン誘導体及びその製造方法
AU621087B2 (en) * 1988-02-13 1992-03-05 Nippon Soda Co., Ltd. Pyridazinone derivatives
DE68924308T2 (de) * 1988-07-11 1996-04-04 Akzo Nobel Nv Pyridazinon-Derivate.
GB9015764D0 (en) * 1990-07-18 1990-09-05 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
HU209388B (en) * 1990-12-27 1994-05-30 Richter Gedeon Vegyeszet Process for producing new 3/2h/-pyridazinones and pharmaceutical compositions comprising same
DE19514568A1 (de) * 1995-04-20 1996-10-24 Merck Patent Gmbh Arylalkyl-pyridazinone
ES2393324T3 (es) 2004-05-14 2012-12-20 Emisphere Technologies, Inc. Compuestos y composiciones para administrar principios activos
EP2502918B1 (en) * 2006-07-25 2015-03-25 Cephalon, Inc. Pyridazinone Derivatives
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
AU2017251537B2 (en) 2016-04-15 2020-10-08 Abbvie Inc. Bromodomain inhibitors
WO2018086703A1 (en) 2016-11-11 2018-05-17 Bayer Pharma Aktiengesellschaft Dihydropyridazinones substituted with phenylureas
EP3746079A1 (en) 2018-01-31 2020-12-09 Bayer Aktiengesellschaft Antibody drug conjugates (adcs) with nampt inhibitors
WO2021013693A1 (en) 2019-07-23 2021-01-28 Bayer Pharma Aktiengesellschaft Antibody drug conjugates (adcs) with nampt inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4055644A (en) * 1970-11-12 1977-10-25 Sandoz, Inc. Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones
JPS5416485A (en) * 1977-07-08 1979-02-07 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivatives and their preparation
US4404203A (en) * 1981-05-14 1983-09-13 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
EP0094555A1 (de) * 1982-05-07 1983-11-23 Bernhard Dr. Kohl Substituierte 2-Pyrazolin-4-essigsäuren, ein Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende Mittel
FR2528837A1 (fr) * 1982-06-18 1983-12-23 Therapeutique Applic Sa Arylacetyl butanolides et leurs derives pyridazinones utilisables comme medicaments, et procedes pour leur fabrication
JPS5953479A (ja) * 1982-09-21 1984-03-28 Mitsui Toatsu Chem Inc ピリダジノン誘導体
US4521416A (en) * 1983-03-22 1985-06-04 Warner-Lambert Company 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones

Also Published As

Publication number Publication date
PL252289A1 (en) 1985-08-13
KR850000431A (ko) 1985-02-27
PH21286A (en) 1987-09-28
ES533538A0 (es) 1985-02-16
EP0129791A3 (de) 1987-06-10
FI842459L (fi) 1984-12-21
PT78757A (de) 1984-07-01
IL72151A (en) 1988-07-31
IL72151A0 (en) 1984-10-31
EP0129791A2 (de) 1985-01-02
PL248285A1 (en) 1985-07-16
US4666902A (en) 1987-05-19
FI842459A7 (fi) 1984-12-21
GR82281B (enExample) 1984-12-13
DK298984A (da) 1984-12-21
AU2951884A (en) 1985-06-13
FI842459A0 (fi) 1984-06-18
DK298984D0 (da) 1984-06-19
PT78757B (de) 1986-07-14
ES8503339A1 (es) 1985-02-16
HUT34961A (en) 1985-05-28
DD223449A5 (de) 1985-06-12
NO842486L (no) 1984-12-21

Similar Documents

Publication Publication Date Title
Yamaguchi et al. Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl) alkyl]-1 (2H)-phthalazinones
EP0159566B1 (en) Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient
EP0072942B1 (en) Pharmaceutically active (3-aminopropoxy)-bibenzyl derivatives
US4053474A (en) Pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine
NO842486L (no) Tetrahydropyridazinonderivater, fremgangsmaate til deres fremstilling og anvendelse
US5750560A (en) Therapeutic compositions based on 1,2-dithiole-3-thione derivatives
WO1983000865A1 (fr) Composes de benzothiazoline
CS195325B2 (en) Method of producing 4-aminoalkoxy-2/2h/pyranones 3-substituted and 5,6-condensed
US5120736A (en) 4-methyl-5-(2-(4-phenylpiperazin-1-yl)ethyl)thiazole derivatives their method of preparation and the pharmaceutical compositions in which they are present
HU193891B (en) Process for production of new derivatives of 1,2,4-triasole
CS214806B2 (en) Method of making the derivatives of the auron
PL123811B1 (en) Process for preparing novel derivatives of pyran-4-one
US3304303A (en) Pyrazole-carboxylic acid-hydrazides
SU428602A3 (ru) Способ получения основпозамещенных производных 1
Buu-Hoi et al. 2-Arylpyrrocolines and 2-arylpyrimidazoles
HU189666B (en) Process for producing thiopyrano-pyrimidine derivatives and acid additional salts
JPS584020B2 (ja) シンキナイソキノリンルイ
JPS6251672A (ja) 新規な２−（４−フエニル−１−ピペラジニルアルキル）アミノピリミジン誘導体及びその酸付加塩
PL88941B1 (en) Indolylacetic acid derivatives[us3812112a]
US3574213A (en) 4,6-di(lower alkyl) pyrimidin-2-yl phthalazine
US3810901A (en) 3-(coumarin-3-ylphenyl)-1,2,4-oxadiazol-5-yl ammonium salts
US3147276A (en) Pyrazolones
US3551502A (en) (2-propynyloxy)-beta-nitro-styrenes
US4904664A (en) Benzene compounds having two pyridazinone substituents
PL89285B1 (enExample)