PH27334A - 1-3-Disubstituted pyrrolidines - Google Patents
1-3-Disubstituted pyrrolidinesInfo
- Publication number
- PH27334A PH27334A PH38535A PH38535A PH27334A PH 27334 A PH27334 A PH 27334A PH 38535 A PH38535 A PH 38535A PH 38535 A PH38535 A PH 38535A PH 27334 A PH27334 A PH 27334A
- Authority
- PH
- Philippines
- Prior art keywords
- disubstituted pyrrolidines
- pyrrolidines
- disubstituted
- Prior art date
Links
- 150000003235 pyrrolidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3812989 | 1988-04-19 | ||
| DE3835291A DE3835291A1 (de) | 1988-04-19 | 1988-10-15 | 1,3-disubstituierte pyrrolidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH27334A true PH27334A (en) | 1993-06-08 |
Family
ID=25867140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH38535A PH27334A (en) | 1988-04-19 | 1989-04-19 | 1-3-Disubstituted pyrrolidines |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5037841A (forum.php) |
| EP (1) | EP0338331B1 (forum.php) |
| JP (1) | JPH01311059A (forum.php) |
| KR (1) | KR900016123A (forum.php) |
| AU (1) | AU625817B2 (forum.php) |
| DE (2) | DE3835291A1 (forum.php) |
| DK (1) | DK186489A (forum.php) |
| ES (1) | ES2045229T3 (forum.php) |
| GR (1) | GR3006744T3 (forum.php) |
| IE (1) | IE62064B1 (forum.php) |
| IL (1) | IL89973A (forum.php) |
| NZ (1) | NZ228766A (forum.php) |
| PH (1) | PH27334A (forum.php) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5231184A (en) * | 1987-11-23 | 1993-07-27 | Janssen Pharmaceutica N.V. | Pridazinamine derivatives |
| US5274097A (en) * | 1988-04-19 | 1993-12-28 | Bayer Aktiengesellschaft | 1,3-disubstituted pyrrolidines |
| US5232978A (en) * | 1988-12-23 | 1993-08-03 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1-(2-arylethyl)-pyrrolidines |
| DE68918832T2 (de) * | 1988-12-28 | 1995-02-09 | Suntory Ltd | Benzoxazepinderivate. |
| US4937235A (en) * | 1989-01-23 | 1990-06-26 | American Cyanamid Company | 3- or 4-substituted oxotremorine derivatives |
| US5281601A (en) * | 1989-12-12 | 1994-01-25 | Pfizer Inc. | Muscarinic receptor antagonists |
| US5948793A (en) * | 1992-10-09 | 1999-09-07 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release |
| US5914328A (en) * | 1992-10-09 | 1999-06-22 | Abbott Laboratories | Heterocyclic ether compounds useful in controlling neurotransmitter release |
| US5874429A (en) * | 1993-12-24 | 1999-02-23 | Suntory Limited | Benzothiazine derivative |
| EP0686632B1 (en) * | 1993-12-24 | 2003-08-06 | Daiichi Suntory Pharma Co., Ltd. | Benzothiazine derivative |
| US6001827A (en) * | 1993-12-24 | 1999-12-14 | Suntory Limited | Benzothiazine derivative |
| CN1148853A (zh) * | 1994-03-31 | 1997-04-30 | 日本化学医药株式会社 | 亚烷基二胺衍生物 |
| US5472958A (en) * | 1994-08-29 | 1995-12-05 | Abbott Laboratories | 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| JPH0977742A (ja) * | 1995-09-12 | 1997-03-25 | Kyorin Pharmaceut Co Ltd | 新規なベンズアミド誘導体 |
| US6437138B1 (en) | 1996-06-06 | 2002-08-20 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
| US6133253A (en) * | 1996-12-10 | 2000-10-17 | Abbott Laboratories | 3-Pyridyl enantiomers and their use as analgesics |
| EP0863136B1 (en) * | 1997-02-25 | 2003-09-24 | Akzo Nobel N.V. | Derivatives of azetidine and pyrrolidine |
| EP1357121A1 (en) | 1997-11-05 | 2003-10-29 | Neurosearch A/S | Azaring-ether deritatives and their use as nicotinic ach receptor modulators |
| KR100498268B1 (ko) * | 1997-12-09 | 2005-11-01 | 주식회사 엘지생활건강 | 피롤리돈계 양쪽성 계면활성제 |
| KR100523184B1 (ko) | 1998-02-26 | 2005-10-24 | 악조 노벨 엔.브이. | 아제티딘 및 피롤리딘의 유도체 |
| US6462091B1 (en) | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
| ES2203239T3 (es) | 1998-12-23 | 2004-04-01 | G.D. Searle Llc | Combinaciones de inhibidores de la proteina de transferencia de ester de colesterilo y de agentes secuestrantes de acidos biliares para indicaciones cardiovasculares. |
| EP1140189B1 (en) | 1998-12-23 | 2003-05-14 | G.D. Searle LLC. | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
| CZ20012341A3 (cs) | 1998-12-23 | 2001-12-12 | G. D. Searle Llc Corparate Patent Department | Kombinace inhibitorů transferoního proteinu cholesterylesterů a derivátů kyseliny fibrové pro kardiovaskulární indikace |
| PL348609A1 (en) | 1998-12-23 | 2002-06-03 | Searle Llc | Combinations of ileal bile acid transport inhibitors and bile acid sequestring agents for cardiovascular indications |
| JP2002533408A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびニコチン酸誘導体の組み合わせ |
| MXPA01006471A (es) | 1998-12-23 | 2004-03-10 | Searle Llc | Combinaciones de inhibidores de transporte de acido biliar ileal e inhibidores de proteina de transferencia de ester colesterilio cpara indicaciones cardiovasculares. |
| US6833370B1 (en) * | 1999-05-21 | 2004-12-21 | Abbott Laboratories | Heterocycle substituted aminoazacycles useful as central nervous system agents |
| EP1286984A2 (en) | 2000-03-10 | 2003-03-05 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| WO2002036560A1 (en) * | 2000-10-30 | 2002-05-10 | Warner-Lambert Company Llc | Aminoalkylpyrrolidine serotonin receptor ligands and compositions, their pharmaceutical uses, and methods for their synthesis |
| AR035235A1 (es) * | 2001-04-20 | 2004-05-05 | Wyeth Corp | Derivados heterocicliloxi-,-tioxi- y -aminobenzazol como ligandos de 5-hidroxitriptamina-6, un procedimiento para su preparacion, composicion farmaceutica, y el uso de dichos derivados para la manufactura de un medicamento |
| IL158448A0 (en) | 2001-04-20 | 2004-05-12 | Wyeth Corp | Heterocyclylalkoxy- alkylthio-and-alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| JP2005518347A (ja) | 2001-11-02 | 2005-06-23 | ジー．ディー． サール エルエルシー | 頂端ナトリウム共依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物 |
| MXPA04006255A (es) | 2002-01-17 | 2004-09-27 | Pharmacia Corp | Compuestos novedosos de alquil/aril hidroxi o ceto tiepina como inhibidores del transporte del acido biliar codependiente del sodio apical y la captacion de taurocolato. |
| GB0402101D0 (en) * | 2004-01-30 | 2004-03-03 | Novartis Ag | Organic compounds |
| CA2573190A1 (en) * | 2004-07-09 | 2006-01-26 | Medisyn Technologies, Inc. | Mt477 and related compounds for the treatment of various cancers |
| JP4167297B2 (ja) * | 2005-08-23 | 2008-10-15 | 株式会社カネカ | ３−アラルキルオキシピロリジン誘導体の製造法 |
| EP1950198B1 (en) * | 2005-10-31 | 2014-08-06 | Toray Fine Chemicals Co., Ltd. | Process for production of benzyloxypyrrolidine derivative, and process for production of hydrochloride salt powder of optically active benzyloxypyrrolidine derivative |
| JP5004067B2 (ja) * | 2005-10-31 | 2012-08-22 | 東レ・ファインケミカル株式会社 | ベンジルオキシ含窒素環状化合物の製造法 |
| JP5004073B2 (ja) * | 2006-06-13 | 2012-08-22 | 東レ・ファインケミカル株式会社 | 光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体及びその製造法 |
| JP5444535B2 (ja) * | 2007-06-05 | 2014-03-19 | インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー | 皮質カテコールアミン作動性神経伝達の調節物質としての新規な二置換フェニルピロリジン |
| TWI438190B (zh) * | 2008-07-24 | 2014-05-21 | Theravance Inc | ３－（苯氧基苯基甲基）吡咯啶化合物 |
| MX2011005088A (es) | 2008-11-14 | 2011-06-01 | Theravance Inc | Proceso para preparar compuestos de 4-[2-(2-fluorofenoximetil)feni l]piperidina. |
| EP2419405A1 (en) * | 2009-04-15 | 2012-02-22 | Theravance, Inc. | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| EP2454234B1 (en) * | 2009-07-13 | 2018-04-11 | Theravance Biopharma R&D IP, LLC | 3-phenoxymethylpyrrolidine compounds |
| US8273786B2 (en) * | 2009-07-21 | 2012-09-25 | Theravance, Inc. | 3-phenoxymethylpyrrolidine compounds |
| EP2523945A1 (en) * | 2010-01-11 | 2012-11-21 | Theravance, Inc. | 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors |
| US8530663B2 (en) * | 2010-03-22 | 2013-09-10 | Theravance, Inc. | 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds |
| US8471040B2 (en) | 2010-10-11 | 2013-06-25 | Theravance, Inc. | Serotonin reuptake inhibitors |
| US8501964B2 (en) | 2010-12-03 | 2013-08-06 | Theravance, Inc. | Serotonin reuptake inhibitors |
| EP2870144B1 (en) | 2012-07-03 | 2017-04-19 | Heptares Therapeutics Limited | Orexin receptor antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821387A (en) * | 1965-10-23 | 1974-06-28 | Robins Co Inc A H | The treatment of parkinsonism with 3-(omega-substituted alkyl)-indoles |
| US3577415A (en) * | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-substituted phenoxypyrrolidines |
| US3577432A (en) * | 1968-12-23 | 1971-05-04 | Robins Co Inc A H | 1-substituted-3-phenoxypyrrolidines |
| NL7304089A (forum.php) * | 1972-03-30 | 1973-10-02 | ||
| DE3717561A1 (de) * | 1987-05-25 | 1988-12-08 | Thomae Gmbh Dr K | Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| PH23283A (en) * | 1986-02-26 | 1989-06-30 | Eisai Co Ltd | Piperidine derivative, pharmaceutical composition containing the same and method of use thereof |
| CH668424A5 (de) * | 1986-06-26 | 1988-12-30 | Lonza Ag | 4-benzyloxy-3-pyrrolin-2-on-l-yl-acetamid, dessen herstellung und verwendung. |
-
1988
- 1988-10-15 DE DE3835291A patent/DE3835291A1/de not_active Withdrawn
-
1989
- 1989-04-06 EP EP89106023A patent/EP0338331B1/de not_active Expired - Lifetime
- 1989-04-06 ES ES89106023T patent/ES2045229T3/es not_active Expired - Lifetime
- 1989-04-06 DE DE8989106023T patent/DE58902481D1/de not_active Expired - Lifetime
- 1989-04-12 US US07/336,977 patent/US5037841A/en not_active Expired - Fee Related
- 1989-04-14 AU AU33059/89A patent/AU625817B2/en not_active Ceased
- 1989-04-17 NZ NZ228766A patent/NZ228766A/en unknown
- 1989-04-17 IL IL89973A patent/IL89973A/xx not_active IP Right Cessation
- 1989-04-18 JP JP1096549A patent/JPH01311059A/ja active Pending
- 1989-04-18 IE IE124089A patent/IE62064B1/en not_active IP Right Cessation
- 1989-04-18 KR KR1019890005201A patent/KR900016123A/ko not_active Ceased
- 1989-04-18 DK DK186489A patent/DK186489A/da not_active Application Discontinuation
- 1989-04-19 PH PH38535A patent/PH27334A/en unknown
-
1993
- 1993-01-07 GR GR930400009T patent/GR3006744T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ228766A (en) | 1991-09-25 |
| DK186489D0 (da) | 1989-04-18 |
| EP0338331B1 (de) | 1992-10-21 |
| KR900016123A (ko) | 1990-11-12 |
| ES2045229T3 (es) | 1994-01-16 |
| AU3305989A (en) | 1989-10-26 |
| GR3006744T3 (forum.php) | 1993-06-30 |
| IL89973A (en) | 1993-01-31 |
| JPH01311059A (ja) | 1989-12-15 |
| EP0338331A1 (de) | 1989-10-25 |
| IE891240L (en) | 1989-10-19 |
| DE3835291A1 (de) | 1989-11-02 |
| DE58902481D1 (de) | 1992-11-26 |
| DK186489A (da) | 1989-10-20 |
| US5037841A (en) | 1991-08-06 |
| IL89973A0 (en) | 1989-12-15 |
| AU625817B2 (en) | 1992-07-16 |
| IE62064B1 (en) | 1994-12-14 |
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