PH19029A - Novel 4-aroylimidazolidin-2-ones and method of use - Google Patents

Novel 4-aroylimidazolidin-2-ones and method of use

Info

Publication number
PH19029A
PH19029A PH28076A PH28076A PH19029A PH 19029 A PH19029 A PH 19029A PH 28076 A PH28076 A PH 28076A PH 28076 A PH28076 A PH 28076A PH 19029 A PH19029 A PH 19029A
Authority
PH
Philippines
Prior art keywords
alkyl
piperazino
hydrogen
lower alkyl
aroylimidazolidin
Prior art date
Application number
PH28076A
Other languages
English (en)
Inventor
Richard Anselm Schnettler
Richard Cyrus Dage
Johann Martin Grisar
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PH19029A publication Critical patent/PH19029A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30Oxygen or sulfur atoms
    • C07D233/32One oxygen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30Oxygen or sulfur atoms
    • C07D233/32One oxygen atom
    • C07D233/38One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Supplying Of Containers To The Packaging Station (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fats And Perfumes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PH28076A 1981-11-04 1982-11-02 Novel 4-aroylimidazolidin-2-ones and method of use PH19029A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/317,963 US4410540A (en) 1981-11-04 1981-11-04 Cardiotonic 4-aroylimidazolidin-2-ones

Publications (1)

Publication Number Publication Date
PH19029A true PH19029A (en) 1985-12-06

Family

ID=23236021

Family Applications (1)

Application Number Title Priority Date Filing Date
PH28076A PH19029A (en) 1981-11-04 1982-11-02 Novel 4-aroylimidazolidin-2-ones and method of use

Country Status (18)

Country Link
US (1) US4410540A (ja)
EP (1) EP0079050B1 (ja)
JP (1) JPS5885865A (ja)
KR (1) KR880002708B1 (ja)
AT (1) ATE26443T1 (ja)
AU (1) AU552310B2 (ja)
CA (1) CA1175829A (ja)
DE (1) DE3275995D1 (ja)
DK (1) DK488482A (ja)
ES (1) ES8405374A1 (ja)
GB (1) GB2110669B (ja)
GR (1) GR77375B (ja)
IE (1) IE54265B1 (ja)
IL (1) IL67133A0 (ja)
NO (1) NO823648L (ja)
NZ (1) NZ202350A (ja)
PH (1) PH19029A (ja)
ZA (1) ZA827974B (ja)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4709043A (en) * 1984-07-09 1987-11-24 Schering A.G. Process for the preparation of imidazolonecarbonylarylimidazoles
US4999365A (en) * 1987-03-20 1991-03-12 Merrell Dow Pharmaceuticals Inc. Method of reducing reperfusion injury with imidazol-2-thiones
JP2002505683A (ja) * 1997-06-18 2002-02-19 シナプティック・ファーマスーティカル・コーポレーション 複素環置換されたピペリジン類及びその使用
US6159990A (en) 1997-06-18 2000-12-12 Synaptic Pharmaceutical Corporation Oxazolidinones as α1A receptor antagonists
WO2000078754A1 (en) * 1999-06-21 2000-12-28 University Of Maryland, Baltimore Thienylhydrazon with digitalis-like properties (positive inotropic effects)
US7091238B1 (en) 1999-06-21 2006-08-15 University Of Maryland Thienylhydrazon with digitalis-like properties (positive inotropic effects)
ES2157822B1 (es) * 1999-08-17 2002-04-16 Kylolab S L Procedimiento para la sintesis de 2-imidazolidinonas poli-sustituidas.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1184709A (fr) * 1957-09-21 1959-07-24 Cfmc Nouveaux dérivés imidazoliques, utilisables comme agents de protection contre les rayons ultra-violets et leurs procédés de fabrication
US3337580A (en) * 1964-12-31 1967-08-22 Robins Co Inc A H 1-hydrocarbon-3 aryl-4-substituted ethyl-2-imidazolidinones
NZ193935A (en) * 1979-06-18 1985-05-31 Richardson Merrell Inc 4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions
PH18106A (en) * 1981-02-18 1985-03-21 Merrell Dow Pharma Novel-4-aroylimidazol-2-ones

Also Published As

Publication number Publication date
ES517042A0 (es) 1984-06-16
IE822621L (en) 1983-05-04
KR880002708B1 (ko) 1988-12-26
GB2110669B (en) 1985-04-11
JPH0435465B2 (ja) 1992-06-11
AU552310B2 (en) 1986-05-29
GB2110669A (en) 1983-06-22
ES8405374A1 (es) 1984-06-16
ZA827974B (en) 1983-08-31
CA1175829A (en) 1984-10-09
ATE26443T1 (de) 1987-04-15
EP0079050B1 (en) 1987-04-08
DK488482A (da) 1983-05-05
IE54265B1 (en) 1989-08-02
KR840002362A (ko) 1984-06-25
US4410540A (en) 1983-10-18
GR77375B (ja) 1984-09-11
NO823648L (no) 1983-05-05
EP0079050A1 (en) 1983-05-18
IL67133A0 (en) 1983-03-31
NZ202350A (en) 1986-04-11
JPS5885865A (ja) 1983-05-23
AU9011182A (en) 1983-05-12
DE3275995D1 (de) 1987-05-14

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