PH12020550660A1 - Cultivation of placenta to isolate exosomes - Google Patents

Cultivation of placenta to isolate exosomes

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Publication number
PH12020550660A1
PH12020550660A1 PH12020550660A PH12020550660A PH12020550660A1 PH 12020550660 A1 PH12020550660 A1 PH 12020550660A1 PH 12020550660 A PH12020550660 A PH 12020550660A PH 12020550660 A PH12020550660 A PH 12020550660A PH 12020550660 A1 PH12020550660 A1 PH 12020550660A1
Authority
PH
Philippines
Prior art keywords
placenta
exosomes
cultivation
isolate
isolate exosomes
Prior art date
Application number
PH12020550660A
Other languages
English (en)
Inventor
Qian Ye
Original Assignee
Celularity Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celularity Inc filed Critical Celularity Inc
Publication of PH12020550660A1 publication Critical patent/PH12020550660A1/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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PH12020550660A 2017-11-16 2020-05-15 Cultivation of placenta to isolate exosomes PH12020550660A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762587335P 2017-11-16 2017-11-16
PCT/US2018/061697 WO2019099955A1 (en) 2017-11-16 2018-11-16 Cultivation of placenta to isolate exosomes

Publications (1)

Publication Number Publication Date
PH12020550660A1 true PH12020550660A1 (en) 2021-04-26

Family

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Application Number Title Priority Date Filing Date
PH12020550660A PH12020550660A1 (en) 2017-11-16 2020-05-15 Cultivation of placenta to isolate exosomes

Country Status (14)

Country Link
US (2) US20190307686A1 (enExample)
EP (1) EP3710575A1 (enExample)
JP (2) JP2021503301A (enExample)
KR (1) KR20200083596A (enExample)
CN (2) CN111433352A (enExample)
AU (1) AU2018370157A1 (enExample)
CA (1) CA3082880A1 (enExample)
EA (1) EA202091219A1 (enExample)
MA (1) MA51649A (enExample)
MX (1) MX2020005100A (enExample)
PH (1) PH12020550660A1 (enExample)
SG (1) SG11202004523SA (enExample)
WO (1) WO2019099955A1 (enExample)
ZA (1) ZA202002775B (enExample)

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US12569517B2 (en) 2019-02-07 2026-03-10 Direct Biologics, Llc Method for treating osteoarthritis with mesenchymal stem cell exosomes
CA3142020A1 (en) * 2019-06-19 2020-12-24 Celularity Inc. Exosomes for disease treatment
US12213995B2 (en) 2019-07-18 2025-02-04 Direct Biologics, Llc Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
EP4065690A4 (en) 2019-11-29 2022-10-05 Rutgers, the State University of New Jersey METHODS OF ISOLATING UMBRELLA PLASMA PRODUCTS, TISSUE AND CELL EXOSOMES AND COMPOSITIONS AND METHODS OF USE THEREOF
KR102615824B1 (ko) * 2020-03-18 2023-12-21 가톨릭대학교 산학협력단 제대혈 혈장 엑소좀 모방체 제작 및 이의 상처치료 용도
EP4136456A1 (en) * 2020-04-17 2023-02-22 Therawis Diagnostics GmbH Method for enriching exosomes
KR20230004709A (ko) * 2020-04-22 2023-01-06 다이렉트 바이오로직스 엘엘씨 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물
US20230183809A1 (en) * 2020-04-22 2023-06-15 Exostem Biotec Ltd. Extracellular vesicles for treatment and diagnosis
KR102317052B1 (ko) * 2020-05-04 2021-10-25 주식회사 티에스셀바이오 태반 유래의 세포외 소포의 항염증 항바이러스 효과 조성물
TW202146034A (zh) * 2020-05-05 2021-12-16 美國商加速生物科學有限公司 包含有分泌蛋白體的藥學與化妝品組成物
WO2021235176A1 (ja) * 2020-05-22 2021-11-25 学校法人麻布獣医学園 アレルゲン不活化剤の評価方法及びアレルゲン不活化剤の評価キット
KR102316777B1 (ko) * 2020-06-26 2021-10-25 주식회사 씨케이엑소젠 엑소좀 생산 조절 세포, 이를 포함하는 조성물, 이로부터 얻은 엑소좀 및 엑소좀 생산 방법
US20230248773A1 (en) * 2020-07-09 2023-08-10 Exo Biologics Sa Extracellular Vesicles and Compositions Thereof
CN112903999A (zh) * 2021-01-20 2021-06-04 蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院） 一种用于纳米流式细胞仪检测的外泌体的制备方法及应用
US12226438B2 (en) * 2021-06-18 2025-02-18 Hilltop BioSciences, Inc. System and method for therapeutic compositions from a plurality of different birth tissues and exosomes
CN113633758B (zh) * 2021-07-29 2025-06-17 复旦大学附属肿瘤医院 一种负载膜结合型肿瘤坏死因子相关凋亡诱导配体和小分子抗肿瘤药物的复合外泌体
JP7044429B1 (ja) * 2021-12-20 2022-03-30 株式会社 バイオミメティクスシンパシーズ 腫瘍を縮小、又は消失させるための組成物
CN121013983A (zh) 2023-04-25 2025-11-25 瑟拉维斯诊断有限责任公司 用于检测和定量外泌体的方法
CN117987350B (zh) * 2024-04-03 2024-06-21 优智嘉(天津)生物科技有限公司 一种人胎盘绒毛外泌体快速提取试剂盒、提取方法、胎盘外泌体及应用
US12502407B2 (en) 2024-04-25 2025-12-23 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles
CN119842608B (zh) * 2025-03-18 2025-07-22 博雅干细胞科技有限公司细胞科技分公司 一种提高脐带血来源nk细胞杀伤力的方法及其应用

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