PH12014500289B1 - Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride - Google Patents
Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochlorideInfo
- Publication number
- PH12014500289B1 PH12014500289B1 PH1/2014/500289A PH12014500289A PH12014500289B1 PH 12014500289 B1 PH12014500289 B1 PH 12014500289B1 PH 12014500289 A PH12014500289 A PH 12014500289A PH 12014500289 B1 PH12014500289 B1 PH 12014500289B1
- Authority
- PH
- Philippines
- Prior art keywords
- isoquinolin
- yloxy
- piperidin
- hydrochloride
- crystalline solvates
- Prior art date
Links
- KMNVOGVCCZNVNU-UHFFFAOYSA-N 6-piperidin-4-yloxy-2h-isoquinolin-1-one;hydrochloride Chemical compound Cl.C=1C=C2C(=O)NC=CC2=CC=1OC1CCNCC1 KMNVOGVCCZNVNU-UHFFFAOYSA-N 0.000 title abstract 2
- 239000012453 solvate Substances 0.000 title abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11305890 | 2011-07-08 | ||
| EP11306033 | 2011-12-29 | ||
| PCT/EP2012/062431 WO2013007518A1 (en) | 2011-07-08 | 2012-06-27 | Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12014500289A1 PH12014500289A1 (en) | 2014-03-24 |
| PH12014500289B1 true PH12014500289B1 (en) | 2019-06-28 |
Family
ID=46397257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2014/500289A PH12014500289B1 (en) | 2011-07-08 | 2012-06-27 | Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride |
Country Status (22)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG2014007520A (en) * | 2011-07-08 | 2014-07-30 | Sanofi Sa | Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0107456A (pt) * | 2000-01-07 | 2002-10-08 | Transform Pharmaceuticals Inc | Formação de amostras, métodos de preparar uma formação de múltiplas formas sólidas de um composto de interesse, de triar uma pluralidade de formas sólidas de um composto de interesse e condições e/ou componentes para compatibilidade com uma ou mais formas sólidas selecionadas de um composto de interesse, de identificar formas sólidas ótimas de um composto de interesse e de determinar conjuntos de condições e/ou componentes para produzir formas sólidas de um composto de interesse, um conjunto de parâmetros de processamento e/ou componentes e as condições e/ou componentes que produzem um composto de interesse ou um seu derivado diastereomérico e sistema para identificar formas sólidas ótimas de um composto de interesse |
| CA2615577C (en) * | 2005-07-26 | 2014-09-09 | Sanofi-Aventis | Piperidinyl-substituted isoquinolone derivatives as rho-kinase inhibitors |
| TW200738682A (en) | 2005-12-08 | 2007-10-16 | Organon Nv | Isoquinoline derivatives |
| WO2007101242A1 (en) | 2006-02-28 | 2007-09-07 | Meadwestvaco Packaging Systems Llc | Carton for tapered and cylindrical articles and blank therefor |
| MY148902A (en) * | 2006-12-27 | 2013-06-14 | Sanofi Aventis | Substituted isoquinolines and their use as rho-kinase inhibitors |
| CN101616909B (zh) * | 2006-12-27 | 2013-09-11 | 塞诺菲-安万特股份有限公司 | 作为Rho-激酶抑制剂的被取代的异喹啉和异喹啉酮衍生物 |
| EP2240441B1 (en) | 2007-12-26 | 2015-06-03 | Sanofi | Process for the preparation of 6-substituted-1-(2h)-isoquinolinones |
| SG2014007520A (en) * | 2011-07-08 | 2014-07-30 | Sanofi Sa | Crystalline solvates of 6-(piperidin-4-yloxy)-2h-isoquinolin-1-one hydrochloride |
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2012
- 2012-06-27 SG SG2014007520A patent/SG2014007520A/en unknown
- 2012-06-27 CA CA2843773A patent/CA2843773C/en active Active
- 2012-06-27 HU HUE12730523A patent/HUE027309T2/en unknown
- 2012-06-27 EP EP12730523.3A patent/EP2729460B1/en active Active
- 2012-06-27 RU RU2014104358A patent/RU2619129C2/ru active
- 2012-06-27 ES ES12730523.3T patent/ES2568245T3/es active Active
- 2012-06-27 HR HRP20160356TT patent/HRP20160356T1/hr unknown
- 2012-06-27 DK DK12730523.3T patent/DK2729460T3/en active
- 2012-06-27 KR KR1020147003354A patent/KR102013566B1/ko active Active
- 2012-06-27 SI SI201230516A patent/SI2729460T1/sl unknown
- 2012-06-27 PL PL12730523T patent/PL2729460T3/pl unknown
- 2012-06-27 AU AU2012283276A patent/AU2012283276B2/en active Active
- 2012-06-27 PH PH1/2014/500289A patent/PH12014500289B1/en unknown
- 2012-06-27 JP JP2014517674A patent/JP6357100B2/ja active Active
- 2012-06-27 US US13/534,815 patent/US8710078B2/en active Active
- 2012-06-27 WO PCT/EP2012/062431 patent/WO2013007518A1/en active Application Filing
- 2012-06-27 IN IN817CHN2014 patent/IN2014CN00817A/en unknown
- 2012-06-27 CN CN201280043723.9A patent/CN103781778B/zh active Active
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2014
- 2014-02-05 CO CO14024164A patent/CO6870040A2/es not_active Application Discontinuation
- 2014-02-06 MA MA36739A patent/MA35340B1/fr unknown
- 2014-02-07 ZA ZA2014/00941A patent/ZA201400941B/en unknown
- 2014-04-04 US US14/245,451 patent/US20140221656A1/en not_active Abandoned
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2016
- 2016-04-12 CY CY20161100305T patent/CY1118326T1/el unknown