PH10667A - 3,3,7,7-bix-(alkylenedioxy)-3alpha-alkyl-6(3-oxobutyl)-perhydro-benz(e)indenes - Google Patents

3,3,7,7-bix-(alkylenedioxy)-3alpha-alkyl-6(3-oxobutyl)-perhydro-benz(e)indenes

Info

Publication number
PH10667A
PH10667A PH14967A PH14967A PH10667A PH 10667 A PH10667 A PH 10667A PH 14967 A PH14967 A PH 14967A PH 14967 A PH14967 A PH 14967A PH 10667 A PH10667 A PH 10667A
Authority
PH
Philippines
Prior art keywords
3alpha
bix
perhydro
indenes
oxobutyl
Prior art date
Application number
PH14967A
Other languages
English (en)
Inventor
G Saucy
J Scott
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PH10667A publication Critical patent/PH10667A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C07J15/005—Retrosteroids (9 beta 10 alfa)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH14967A 1968-11-22 1973-08-27 3,3,7,7-bix-(alkylenedioxy)-3alpha-alkyl-6(3-oxobutyl)-perhydro-benz(e)indenes PH10667A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77831468A 1968-11-22 1968-11-22

Publications (1)

Publication Number Publication Date
PH10667A true PH10667A (en) 1977-08-02

Family

ID=25112933

Family Applications (2)

Application Number Title Priority Date Filing Date
PH14967A PH10667A (en) 1968-11-22 1973-08-27 3,3,7,7-bix-(alkylenedioxy)-3alpha-alkyl-6(3-oxobutyl)-perhydro-benz(e)indenes
PH14968A PH11342A (en) 1968-11-22 1973-08-27 Novel substituted perhydro-benz(n)indenes

Family Applications After (1)

Application Number Title Priority Date Filing Date
PH14968A PH11342A (en) 1968-11-22 1973-08-27 Novel substituted perhydro-benz(n)indenes

Country Status (19)

Country Link
US (1) US3700661A (da)
JP (1) JPS5022031B1 (da)
AT (8) AT295757B (da)
BE (4) BE742089A (da)
BR (4) BR6914375D0 (da)
CA (2) CA918669A (da)
CH (10) CH537938A (da)
DE (3) DE1958601A1 (da)
DK (4) DK130117B (da)
ES (5) ES373751A1 (da)
FI (1) FI47572C (da)
FR (4) FR2024918A1 (da)
GB (9) GB1298216A (da)
IE (1) IE33651B1 (da)
IL (2) IL33369A (da)
NL (4) NL6917499A (da)
NO (1) NO133806C (da)
PH (2) PH10667A (da)
SE (5) SE376422B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984428A (en) * 1968-11-22 1976-10-05 Hoffmann-La Roche Inc. Isoxazolyl-substituted perhydrobenzindenes
US3991084A (en) * 1970-08-26 1976-11-09 Hoffmann-La Roche Inc. Steroid total synthesis process utilizing a cyanoalkyl A-ring precursor
US3994930A (en) * 1970-08-26 1976-11-30 Hoffmann-La Roche Inc. 6-(3-Cyanopropyl)-2-vinyl tetrahydropyran-2-ol and its tautomer
US3873562A (en) * 1972-06-05 1975-03-25 Hoffmann La Roche 1-(4-Isoxazolyl)-7-hydroxy-3-heptanones
US3873561A (en) * 1972-06-05 1975-03-25 Hoffmann La Roche 7-(4-Isoxazolyl)-5-oxo-heptanals
US3900491A (en) * 1972-06-05 1975-08-19 Hoffmann La Roche 1-(4-isoxazolyl)-7-hydroxy-2-hydroxyimino heptanes
US3994926A (en) * 1973-05-24 1976-11-30 Hoffmann-La Roche Inc. Aryl ketals of polycyclic oxo compounds and processes
US3855209A (en) * 1973-09-04 1974-12-17 Eastman Kodak Co Synthesis of indolininium methine dyes
US4054583A (en) * 1976-07-06 1977-10-18 Eli Lilly And Company Process for converting 2,7-dihydroxy-5-isopropylidene-9-substituted-2,6-methano-3,4,5,6-tetrahydro-2H-1-benzoxocin to trans-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo(b,d)pyran-9-one
US6030970A (en) * 1995-08-02 2000-02-29 Smithkline Beecham Corporation Endothelin receptor antagonists
ES2195002T3 (es) * 1995-08-02 2003-12-01 Smithkline Beecham Corp Antagonistas de los receptores de la endotelina.
WO1997028160A1 (en) * 1996-02-01 1997-08-07 Smithkline Beecham Corporation Endothelin receptor antagonists
US6174906B1 (en) 1999-10-01 2001-01-16 Smithkline Beecham Corporation Endothelin receptor antagonists

Also Published As

Publication number Publication date
FR2024919A1 (da) 1970-09-04
CH567490A5 (da) 1975-10-15
CA918669A (en) 1973-01-09
ES401968A1 (es) 1976-04-16
SE361887B (da) 1973-11-19
NO133806C (da) 1976-06-30
NL6917554A (da) 1970-05-26
CH537942A (de) 1973-07-31
DK129090B (da) 1974-08-19
GB1298218A (en) 1972-11-29
SE364715B (da) 1974-03-04
GB1298216A (en) 1972-11-29
CH574890A5 (da) 1976-04-30
DE1958600B2 (de) 1979-11-29
AT304772B (de) 1973-01-25
AT299463B (de) 1972-06-26
GB1298219A (en) 1972-11-29
BE742090A (da) 1970-05-25
CH567523A5 (da) 1975-10-15
NL6917557A (da) 1970-05-26
AT292695B (de) 1971-09-10
NL6917574A (da) 1970-05-26
BR6914372D0 (pt) 1973-02-08
IE33651B1 (en) 1974-09-18
CH529774A (de) 1972-10-31
DK126655B (da) 1973-08-06
US3700661A (en) 1972-10-24
ES373754A1 (es) 1972-04-01
FR2024920A1 (da) 1970-09-04
AT308981B (de) 1973-07-25
AT294331B (de) 1971-11-25
NL6917499A (da) 1970-05-26
SE376422B (da) 1975-05-26
FI47572B (da) 1973-10-01
ES373751A1 (es) 1972-02-01
IL33369A (en) 1973-10-25
DK130117B (da) 1974-12-23
CH578547A5 (da) 1976-08-13
DE1958601A1 (de) 1970-06-18
IL42366A0 (en) 1973-07-30
ES373752A1 (es) 1973-04-16
JPS5022031B1 (da) 1975-07-28
BR6914373D0 (pt) 1973-02-08
AT295757B (de) 1972-01-25
BE742088A (da) 1970-05-25
GB1298214A (en) 1972-11-29
FI47572C (fi) 1974-01-10
FR2030078A1 (da) 1970-10-30
DE1958600C3 (de) 1980-08-07
BR6914375D0 (pt) 1973-04-19
GB1298215A (en) 1972-11-29
CH568314A5 (da) 1975-10-31
GB1298212A (en) 1972-11-29
CH537938A (de) 1973-07-31
NO133806B (da) 1976-03-22
GB1298217A (en) 1972-11-29
BE742089A (da) 1970-05-25
DK127975B (da) 1974-02-11
PH11342A (en) 1977-11-02
DE1958608A1 (de) 1970-06-18
AT292694B (de) 1971-09-10
SE354657B (da) 1973-03-19
GB1298213A (en) 1972-11-29
ES373753A1 (es) 1973-04-16
IL33369A0 (en) 1970-01-29
AT294832B (de) 1971-12-10
GB1298211A (en) 1972-11-29
DK130117C (da) 1975-06-09
IE33651L (en) 1970-05-22
BR6914374D0 (pt) 1973-04-19
CH561192A5 (da) 1975-04-30
CH567489A5 (da) 1975-10-15
SE355801B (da) 1973-05-07
CA944770A (en) 1974-04-02
DE1958600A1 (de) 1970-07-09
FR2024918A1 (da) 1970-09-04
BE742087A (da) 1970-05-25

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