PE20240367A1 - Forma cristalina iv del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma - Google Patents
Forma cristalina iv del compuesto agonista de receptor de melanocortina y metodo de preparacion para la mismaInfo
- Publication number
- PE20240367A1 PE20240367A1 PE2023001516A PE2023001516A PE20240367A1 PE 20240367 A1 PE20240367 A1 PE 20240367A1 PE 2023001516 A PE2023001516 A PE 2023001516A PE 2023001516 A PE2023001516 A PE 2023001516A PE 20240367 A1 PE20240367 A1 PE 20240367A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- crystalline form
- receptor agonist
- melanocortin receptor
- agonist compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940117029 Melanocortin receptor agonist Drugs 0.000 title 1
- 239000000336 melanocortin receptor agonist Substances 0.000 title 1
- 102000001796 Melanocortin 4 receptors Human genes 0.000 abstract 2
- 108010021436 Type 4 Melanocortin Receptor Proteins 0.000 abstract 2
- WFKAJVHLWXSISD-UHFFFAOYSA-N isobutyramide Chemical compound CC(C)C(N)=O WFKAJVHLWXSISD-UHFFFAOYSA-N 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229940047889 isobutyramide Drugs 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
SE REFIERE A LA FORMA CRISTALINA IV DEL HIDRATO DE CLORHIDRATO DE N-((3S,5S)-1-((3S,4R)-1-(TER-BUTIL)-4-(4-CLOROFENIL)PIRROLIDIN-3-CARBONIL)-5-(MORFOLIN-4-CARBONIL)-PIRROLIDIN-3-IL)-N-((1S,4R)-4-METILCICLOHEXIL)ISOBUTIRAMIDA CUYO PATRON DE DIFRACCION DE POLVO DE RAYOS X PRESENTA PICOS CARACTERISTICOS CON LOS SIGUIENTES ANGULOS DE DIFRACCION (VALORES 2THETA) DE: 7.76±0.2°, 9.69±0.2°, 10.12±0.2°, 10.63±0.2°, 11.93±0.2°, 12.72±0.2°, 14.57±0.2°, 16.07±0.2°, 17.65±0.2°, 18.24±0.2°, 19.10±0.2°, 19.62±0.2°, 20.09±0.2°, 21.19±0.2°, 21.62±0.2°, 22.02±0.2°, 22.25±0.2°, 22.61±0.2°, 23.59±0.2°, 24.26±0.2°, 24.78±0.2°, 25.29±0.2°, 26.15±0.2°, 28.52±0.2°, 29.38±0.2° y 29.98±0.2°. TAMBIEN SE REFIERE A UN METODO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA QUE LO COMPRENDE. DICHO COMPUESTO ES AGONISTA DEL RECEPTOR DE MELANOCORTINA-4 (MC4R) SIENDO UTIL EN EL TRATAMIENTO DE OBESIDAD, DIABETES.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20200142400 | 2020-10-29 | ||
| PCT/KR2021/015475 WO2022092914A1 (ko) | 2020-10-29 | 2021-10-29 | 멜라노코르틴 수용체 작용제 화합물의 결정형 ⅳ 및 이의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20240367A1 true PE20240367A1 (es) | 2024-03-04 |
Family
ID=81384123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023001516A PE20240367A1 (es) | 2020-10-29 | 2021-10-29 | Forma cristalina iv del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20240010633A1 (es) |
| EP (1) | EP4219475A4 (es) |
| JP (1) | JP2023548161A (es) |
| KR (1) | KR20220057473A (es) |
| CN (1) | CN116507614A (es) |
| AU (1) | AU2021367714B2 (es) |
| CA (1) | CA3195328A1 (es) |
| CL (1) | CL2023001225A1 (es) |
| CO (1) | CO2023006521A2 (es) |
| IL (1) | IL302429A (es) |
| MX (1) | MX2023004731A (es) |
| PE (1) | PE20240367A1 (es) |
| WO (1) | WO2022092914A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112021022497A2 (pt) * | 2019-11-07 | 2022-05-17 | Lg Chemical Ltd | Composto, composição farmacêutica, uso da composição farmacêutica, e, métodos para prevenir ou tratar obesidade, diabetes, inflamação e disfunção erétil |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2377369A1 (en) * | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
| WO2002059107A1 (en) * | 2001-01-23 | 2002-08-01 | Eli Lilly And Company | Substituted piperidines/piperazines as melanocortin receptor agonists |
| AR044510A1 (es) | 2003-04-14 | 2005-09-14 | Merck & Co Inc | Procedimiento e intermedios para preparar acidos carboxilicos de pirrolidina |
| TWI341835B (en) * | 2003-11-12 | 2011-05-11 | Lg Life Sciences Ltd | Melanocortin receptor agonists |
| TWI332501B (en) | 2006-07-14 | 2010-11-01 | Lg Life Sciences Ltd | Melanocortin receptor agonists |
| UA99555C2 (en) * | 2008-11-12 | 2012-08-27 | Элджи Лайф Саенсез Лтд. | Melanocortin receptor agonists |
| BR112019016488B1 (pt) | 2017-02-08 | 2022-11-16 | Tilray, Inc | Método e aparato para processamento de cannabis com energia radiante de baixa pressão |
| BR112021022497A2 (pt) * | 2019-11-07 | 2022-05-17 | Lg Chemical Ltd | Composto, composição farmacêutica, uso da composição farmacêutica, e, métodos para prevenir ou tratar obesidade, diabetes, inflamação e disfunção erétil |
-
2021
- 2021-10-29 JP JP2023526431A patent/JP2023548161A/ja active Pending
- 2021-10-29 CN CN202180073211.6A patent/CN116507614A/zh active Pending
- 2021-10-29 WO PCT/KR2021/015475 patent/WO2022092914A1/ko active Application Filing
- 2021-10-29 KR KR1020210146191A patent/KR20220057473A/ko active IP Right Grant
- 2021-10-29 AU AU2021367714A patent/AU2021367714B2/en active Active
- 2021-10-29 CA CA3195328A patent/CA3195328A1/en active Pending
- 2021-10-29 EP EP21886908.9A patent/EP4219475A4/en active Pending
- 2021-10-29 IL IL302429A patent/IL302429A/en unknown
- 2021-10-29 PE PE2023001516A patent/PE20240367A1/es unknown
- 2021-10-29 MX MX2023004731A patent/MX2023004731A/es unknown
- 2021-10-29 US US18/251,111 patent/US20240010633A1/en active Pending
-
2023
- 2023-04-27 CL CL2023001225A patent/CL2023001225A1/es unknown
- 2023-05-17 CO CONC2023/0006521A patent/CO2023006521A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220057473A (ko) | 2022-05-09 |
| JP2023548161A (ja) | 2023-11-15 |
| EP4219475A1 (en) | 2023-08-02 |
| CL2023001225A1 (es) | 2023-11-03 |
| CA3195328A1 (en) | 2022-05-05 |
| CN116507614A (zh) | 2023-07-28 |
| EP4219475A4 (en) | 2024-03-13 |
| WO2022092914A1 (ko) | 2022-05-05 |
| CO2023006521A2 (es) | 2023-08-18 |
| MX2023004731A (es) | 2023-05-10 |
| AU2021367714A1 (en) | 2023-06-01 |
| US20240010633A1 (en) | 2024-01-11 |
| IL302429A (en) | 2023-06-01 |
| AU2021367714B2 (en) | 2024-01-25 |
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