WO2019059557A3 - Sglt-2 저해제 및 안지오텐신 수용체 차단제를 포함하는 의약 조성물 - Google Patents

Sglt-2 저해제 및 안지오텐신 수용체 차단제를 포함하는 의약 조성물 Download PDF

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Publication number
WO2019059557A3
WO2019059557A3 PCT/KR2018/010110 KR2018010110W WO2019059557A3 WO 2019059557 A3 WO2019059557 A3 WO 2019059557A3 KR 2018010110 W KR2018010110 W KR 2018010110W WO 2019059557 A3 WO2019059557 A3 WO 2019059557A3
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Prior art keywords
sglt
inhibitor
medicinal composition
receptor blocker
angiotensin receptor
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PCT/KR2018/010110
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English (en)
French (fr)
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WO2019059557A2 (ko
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김태훈
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오토텔릭바이오 주식회사
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Priority to MX2020003088A priority Critical patent/MX2020003088A/es
Priority to BR112020004107-6A priority patent/BR112020004107B1/pt
Priority to RU2020113679A priority patent/RU2778313C2/ru
Priority to US16/485,888 priority patent/US10980822B2/en
Priority to CN201880012039.1A priority patent/CN110520133A/zh
Priority to JP2020517135A priority patent/JP6993502B2/ja
Publication of WO2019059557A2 publication Critical patent/WO2019059557A2/ko
Publication of WO2019059557A3 publication Critical patent/WO2019059557A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

유효성분으로서 당뇨병 치료제 및 고혈압 치료제를 포함하는 의약 조성물이 제공된다.
PCT/KR2018/010110 2017-09-19 2018-08-31 Sglt-2 저해제 및 안지오텐신 수용체 차단제를 포함하는 의약 조성물 WO2019059557A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MX2020003088A MX2020003088A (es) 2017-09-19 2018-08-31 Composicion medicinal que comprende el inhibidor del sglt2 y el antagonista del receptor de angiotensina.
BR112020004107-6A BR112020004107B1 (pt) 2017-09-19 2018-08-31 Composição medicinal compreendendo inibidor de sglt-2 e bloqueador do receptor de angiotensina
RU2020113679A RU2778313C2 (ru) 2017-09-19 2018-08-31 Лекарственная композиция, включающая ингибитор sglt-2 и блокатор рецептора ангиотензина
US16/485,888 US10980822B2 (en) 2017-09-19 2018-08-31 Medicinal composition comprising SGLT-2 inhibitor and angiotensin receptor blocker
CN201880012039.1A CN110520133A (zh) 2017-09-19 2018-08-31 包含钠-葡萄糖协同转运蛋白-2抑制剂及血管紧张素受体阻滞剂的医药组合物
JP2020517135A JP6993502B2 (ja) 2017-09-19 2018-08-31 Ｓｇｌｔ－２阻害剤とアンジオテンシン受容体拮抗薬を含む医薬組成物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2017-0120311 2017-09-19
KR20170120311 2017-09-19
KR1020180075025A KR101943382B1 (ko) 2017-09-19 2018-06-28 Sglt-2 저해제 및 안지오텐신 수용체 차단제를 포함하는 의약 조성물
KR10-2018-0075025 2018-06-28

Publications (2)

Publication Number Publication Date
WO2019059557A2 WO2019059557A2 (ko) 2019-03-28
WO2019059557A3 true WO2019059557A3 (ko) 2019-05-09

Family

ID=65323033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/010110 WO2019059557A2 (ko) 2017-09-19 2018-08-31 Sglt-2 저해제 및 안지오텐신 수용체 차단제를 포함하는 의약 조성물

Country Status (6)

Country Link
US (1) US10980822B2 (ko)
JP (1) JP6993502B2 (ko)
KR (1) KR101943382B1 (ko)
CN (1) CN110520133A (ko)
MX (1) MX2020003088A (ko)
WO (1) WO2019059557A2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021000139A2 (pt) 2018-07-19 2021-04-06 Astrazeneca Ab Métodos de tratamento da hfpef empregando dapagliflozina e composições compreendendo a mesma
US10973836B2 (en) 2019-08-30 2021-04-13 Astrazeneca Ab Methods of treating heart failure with reduced ejection fraction
WO2021176096A1 (en) * 2020-03-05 2021-09-10 Krka, D.D., Novo Mesto Pharmaceutical composition comprising sglt2 inhibitor
KR20230057388A (ko) * 2020-08-17 2023-04-28 티엔진 크레아트론 바이오테크놀로지 컴파니 리미티드 Sglt-2 억제제와 안지오텐신 수용체 길항제의 조성물 및 이의 용도
CN115894454A (zh) * 2021-09-06 2023-04-04 天地恒一制药股份有限公司 坎地沙坦的复合物，及其制备方法与应用
CN118251223A (zh) * 2021-10-27 2024-06-25 株式会社迈蒂泰克 包含血管紧张素受体阻断剂和sglt2抑制剂的复合组合物
KR20230091684A (ko) * 2021-12-16 2023-06-23 주식회사 종근당 다파글리플로진과 시타글립틴을 포함하며, 정제사이즈 축소를 통해 복용편의성이 향상된 약제학적 복합제제 및 이의 제조방법
KR20240099022A (ko) * 2022-12-20 2024-06-28 주식회사 티에치팜 나트륨 포도당 운반체-2 저해제 및 안지오텐신 ⅱ 수용체 차단제를 함유하는 경구용 약학 제제
WO2024136185A1 (ko) * 2022-12-20 2024-06-27 주식회사 티에치팜 나트륨 포도당 운반체-2 저해제 및 안지오텐신 ⅱ 수용체 차단제를 함유하는 심혈관 질환 예방 또는 치료용 약학적 조성물

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KR20070098811A (ko) * 2005-01-07 2007-10-05 다이쇼 세이야꾸 가부시끼가이샤 1-티오-ｄ-글루시톨 유도체
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KR20150046125A (ko) * 2012-08-30 2015-04-29 다이쇼 세이야꾸 가부시끼가이샤 Sglt2 저해약과 항고혈압약의 조합

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KR20070098811A (ko) * 2005-01-07 2007-10-05 다이쇼 세이야꾸 가부시끼가이샤 1-티오-ｄ-글루시톨 유도체
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Also Published As

Publication number Publication date
WO2019059557A2 (ko) 2019-03-28
JP2020534347A (ja) 2020-11-26
JP6993502B2 (ja) 2022-01-13
RU2020113679A3 (ko) 2021-10-20
MX2020003088A (es) 2020-08-17
US10980822B2 (en) 2021-04-20
US20200054656A1 (en) 2020-02-20
CN110520133A (zh) 2019-11-29
KR101943382B1 (ko) 2019-01-29
RU2020113679A (ru) 2021-10-20
BR112020004107A2 (pt) 2020-09-24

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