PE20240069A1 - Compuestos heterociclicos capaces de activar sting - Google Patents
Compuestos heterociclicos capaces de activar stingInfo
- Publication number
- PE20240069A1 PE20240069A1 PE2023002941A PE2023002941A PE20240069A1 PE 20240069 A1 PE20240069 A1 PE 20240069A1 PE 2023002941 A PE2023002941 A PE 2023002941A PE 2023002941 A PE2023002941 A PE 2023002941A PE 20240069 A1 PE20240069 A1 PE 20240069A1
- Authority
- PE
- Peru
- Prior art keywords
- 6alkyl
- heterocyclic compounds
- compounds capable
- activating sting
- group
- Prior art date
Links
- 230000003213 activating effect Effects 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se refiere a un compuesto de Formula (I) en donde A es N o C, B es un grupo seleccionado de un heterociclilo monociclico de 5-7 miembros que tiene 1 o 2 atomos de N, un heterociclilo biciclico de 6 miembros que contiene 1 atomo de N, etc; D es un grupo seleccionado del grupo que consiste en un heterociclilo biciclico de 10 miembros que contiene 1 atomo de N, y benzodioxol; R1 se selecciona de H, C1-6alquilo, CF3, etc.; R2 se selecciona de H, C1-6alquilo, C1-6alquileno-OH; -C(O)OH, etc.; R3 es H o C1-6-alquilo; R4 es H, C1-3alquilo, NH2, etc.; R5 esta ausente o se selecciona de H, C1-6alquilo, S(O2)C1-6alquilo, etc.; R6 esta ausente o se selecciona de H, C1-6alquilo, =O y C(O)OH; o una sal de este; ademas, una combinacion que comprende uno o mas compuestos de Formula (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21171155 | 2021-04-29 | ||
| PCT/EP2022/061379 WO2022229341A1 (en) | 2021-04-29 | 2022-04-28 | Heterocyclic compounds capable of activating sting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20240069A1 true PE20240069A1 (es) | 2024-01-11 |
Family
ID=75825418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2023002941A PE20240069A1 (es) | 2021-04-29 | 2022-04-28 | Compuestos heterociclicos capaces de activar sting |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20220388986A1 (es) |
| EP (1) | EP4330250A1 (es) |
| JP (1) | JP2024514361A (es) |
| KR (1) | KR20240004646A (es) |
| CN (1) | CN117255784A (es) |
| AR (1) | AR125477A1 (es) |
| AU (1) | AU2022265323B2 (es) |
| BR (1) | BR112023017873A2 (es) |
| CA (1) | CA3214127A1 (es) |
| CL (1) | CL2023002959A1 (es) |
| CO (1) | CO2023014672A2 (es) |
| CR (1) | CR20230509A (es) |
| DO (1) | DOP2023000234A (es) |
| EC (1) | ECSP23069018A (es) |
| IL (1) | IL307977A (es) |
| PE (1) | PE20240069A1 (es) |
| TW (1) | TW202309031A (es) |
| WO (1) | WO2022229341A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024089155A1 (en) * | 2022-10-28 | 2024-05-02 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as sting antagonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR090151A1 (es) | 2012-03-07 | 2014-10-22 | Lilly Co Eli | Compuestos inhibidores de raf |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| TW202016151A (zh) | 2018-06-09 | 2020-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
| JP2021529833A (ja) * | 2018-07-03 | 2021-11-04 | アイエフエム デュー インコーポレイテッド | Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物 |
| TW202028212A (zh) | 2018-10-11 | 2020-08-01 | 日商小野藥品工業股份有限公司 | Ｓｔｉｎｇ促效化合物 |
| CN113563313B (zh) * | 2019-01-31 | 2022-11-04 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CN112521394A (zh) * | 2019-09-19 | 2021-03-19 | 中国药科大学 | 杂环酰胺类化合物、其可药用的盐及其制备方法和用途 |
| AU2020355343B2 (en) * | 2019-09-25 | 2023-11-30 | Pfizer Inc. | Polyheterocyclic modulators of STING (stimulator of interferon genes) |
| TW202128756A (zh) | 2019-10-02 | 2021-08-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於癌症治療之多重專一性結合蛋白 |
| CN112869927A (zh) | 2019-11-29 | 2021-06-01 | 百安健康复医疗（深圳）有限公司 | 用于治疗膝骨性关节炎的矫正器 |
-
2022
- 2022-04-27 US US17/730,395 patent/US20220388986A1/en active Pending
- 2022-04-28 IL IL307977A patent/IL307977A/en unknown
- 2022-04-28 CN CN202280030669.8A patent/CN117255784A/zh active Pending
- 2022-04-28 CR CR20230509A patent/CR20230509A/es unknown
- 2022-04-28 KR KR1020237040758A patent/KR20240004646A/ko unknown
- 2022-04-28 BR BR112023017873A patent/BR112023017873A2/pt unknown
- 2022-04-28 AR ARP220101113A patent/AR125477A1/es unknown
- 2022-04-28 PE PE2023002941A patent/PE20240069A1/es unknown
- 2022-04-28 WO PCT/EP2022/061379 patent/WO2022229341A1/en active Application Filing
- 2022-04-28 AU AU2022265323A patent/AU2022265323B2/en active Active
- 2022-04-28 TW TW111116155A patent/TW202309031A/zh unknown
- 2022-04-28 CA CA3214127A patent/CA3214127A1/en active Pending
- 2022-04-28 JP JP2023564644A patent/JP2024514361A/ja active Pending
- 2022-04-28 EP EP22727008.9A patent/EP4330250A1/en active Pending
-
2023
- 2023-09-13 EC ECSENADI202369018A patent/ECSP23069018A/es unknown
- 2023-10-03 CL CL2023002959A patent/CL2023002959A1/es unknown
- 2023-10-20 DO DO2023000234A patent/DOP2023000234A/es unknown
- 2023-10-30 CO CONC2023/0014672A patent/CO2023014672A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP4330250A1 (en) | 2024-03-06 |
| AU2022265323A1 (en) | 2023-09-14 |
| DOP2023000234A (es) | 2023-11-30 |
| WO2022229341A1 (en) | 2022-11-03 |
| CL2023002959A1 (es) | 2024-03-01 |
| IL307977A (en) | 2023-12-01 |
| US20220388986A1 (en) | 2022-12-08 |
| CO2023014672A2 (es) | 2023-11-10 |
| CA3214127A1 (en) | 2022-11-03 |
| ECSP23069018A (es) | 2023-10-31 |
| AU2022265323B2 (en) | 2024-05-16 |
| KR20240004646A (ko) | 2024-01-11 |
| TW202309031A (zh) | 2023-03-01 |
| CN117255784A (zh) | 2023-12-19 |
| AR125477A1 (es) | 2023-07-19 |
| JP2024514361A (ja) | 2024-04-01 |
| BR112023017873A2 (pt) | 2023-12-12 |
| CR20230509A (es) | 2023-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20210050A1 (es) | Nuevos compuestos de sulfonamida carboxamida | |
| CL2018003021A1 (es) | Compuestos heteroaril-1,2,4-triazol y heteroaril-tetrazol | |
| PE20210140A1 (es) | Moduladores de la proteina reguladora de conductancia transmembrana de la fibrosis quistica y metodos de uso | |
| PE20190260A1 (es) | Isoquinolin-3-il-carboxamidas, y preparacion y uso de las mismas | |
| PE20240069A1 (es) | Compuestos heterociclicos capaces de activar sting | |
| AR105459A1 (es) | Derivados de pirrolo[2,1-f][1,2,4]triazina útiles para tratar trastornos relacionados con kit y pdfgr | |
| AR065806A1 (es) | Derivados de quinolina, procesos para su preparacion, composiciones farmaceuticas que los contienen y usos para el tratamiento de la artritis reumatoidea. | |
| MX165852B (es) | Metodo para estabilizar una pelicula polimerica, revestimiento o articulo moldeado | |
| AR053228A1 (es) | Derivados de azol en calidad de inibidores de lipasas y fosfolipasas | |
| AR088449A1 (es) | Benzilindazoles sustituidos | |
| DOP2016000267A (es) | Composiciones estables de yodo no en complejo y métodos de uso | |
| AR108629A1 (es) | Derivados de tiazol microbiocidas | |
| AR052913A1 (es) | Pirazolopirimidinas | |
| AR051431A1 (es) | Compuestos de pirazolina substituidos, su preparacion y su uso como medicamentos | |
| PE20181924A1 (es) | Inhibidores de la arginasa y sus aplicaciones terapeuticas | |
| AR105893A1 (es) | Derivados del anillo (hetero) aromático sustituidos con carboxi como inhibidores de xantina oxidasa y del transportador 1 del anión urato | |
| AR112274A1 (es) | Compuestos bicíclicos de cetona y sus métodos de uso | |
| AR118724A1 (es) | Inhibidores de dihidroorotato deshidrogenasa | |
| AR077080A1 (es) | Compuestos de 2,3-dihidro-1h-indeno | |
| CL2019001041A1 (es) | Compuestos terapéuticos y métodos para utilizarlos. | |
| MD3438095T2 (ro) | Compus de piridazinonă sau sarea sa, și erbicid care îl conţine | |
| AR113842A1 (es) | Derivados de tiazol microbiocidas | |
| AR090376A1 (es) | Compuestos herbicidas | |
| PE20171257A1 (es) | Analogos de urea unidos sustituidos como moduladores de sirtuina | |
| AR124051A1 (es) | Compuestos herbicidas de n-heteroarilpirazol |