PE20212073A1 - Modificacion de un anticuerpo para la union selectiva al tumor de cd47 - Google Patents
Modificacion de un anticuerpo para la union selectiva al tumor de cd47Info
- Publication number
- PE20212073A1 PE20212073A1 PE2021001666A PE2021001666A PE20212073A1 PE 20212073 A1 PE20212073 A1 PE 20212073A1 PE 2021001666 A PE2021001666 A PE 2021001666A PE 2021001666 A PE2021001666 A PE 2021001666A PE 20212073 A1 PE20212073 A1 PE 20212073A1
- Authority
- PE
- Peru
- Prior art keywords
- binds
- fab
- tumor
- antibody
- modification
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Esta referido a anticuerpos que comprenden al menos una parte de Fab que se une a CD47 y al menos una parte de Fab que se une al antigeno asociado al tumor (TAA) CD20; en donde la parte de Fab que se une a CD47 exhibe baja afinidad para CD47; y, en donde la parte de Fab que se une a CD20 exhibe alta afinidad para CD20; y en donde el anticuerpo se une de manera selectiva a CD47 y bloquea la interaccion de CD47 con SIRPalfa en celulas tumorales a la vez que no exhibe una union sustancial a CD47 en celulas normales. Estos anticuerpos se emplean en el tratamiento de neoplasias malignas hematologicas o de trastornos de linfocitos B en un paciente
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962830335P | 2019-04-05 | 2019-04-05 | |
PCT/US2020/026579 WO2020206255A1 (en) | 2019-04-05 | 2020-04-03 | Engineering of an antibody for tumor-selective binding of cd47 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20212073A1 true PE20212073A1 (es) | 2021-10-26 |
Family
ID=70457134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021001666A PE20212073A1 (es) | 2019-04-05 | 2020-04-03 | Modificacion de un anticuerpo para la union selectiva al tumor de cd47 |
Country Status (18)
Country | Link |
---|---|
US (2) | US20220162330A1 (es) |
EP (2) | EP3946633A1 (es) |
JP (2) | JP2022535324A (es) |
KR (2) | KR20210148290A (es) |
CN (2) | CN114667168A (es) |
AR (2) | AR118595A1 (es) |
AU (1) | AU2020252402A1 (es) |
BR (1) | BR112021019714A2 (es) |
CA (1) | CA3134964A1 (es) |
CL (1) | CL2021002608A1 (es) |
CO (1) | CO2021013836A2 (es) |
EA (1) | EA202192729A1 (es) |
IL (1) | IL286889A (es) |
MX (1) | MX2021012178A (es) |
PE (1) | PE20212073A1 (es) |
SG (1) | SG11202110736VA (es) |
TW (2) | TW202104260A (es) |
WO (2) | WO2020206255A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4376884A1 (en) * | 2021-07-30 | 2024-06-05 | Ludwig-Maximilians-Universität München | Anti-cd47 antibodies and use thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE13746964T2 (hu) | 2012-02-06 | 2020-01-28 | Inhibrx Inc | CD47 antitestek és alkalmazási eljárásaik |
ES2773107T3 (es) * | 2012-10-05 | 2020-07-09 | Kyowa Kirin Co Ltd | Composición de proteína heterodimérica |
ES2876009T3 (es) * | 2012-12-27 | 2021-11-11 | Chugai Pharmaceutical Co Ltd | Polipéptido heterodimerizado |
EP4137518A1 (en) * | 2013-02-06 | 2023-02-22 | Inhibrx, Inc. | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
US20160009824A1 (en) * | 2013-03-15 | 2016-01-14 | Merck Patent Gmbh | Tetravalent bispecific antibodies |
US10087257B2 (en) * | 2014-08-08 | 2018-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | SIRP alpha-antibody fusion proteins |
ES2751915T5 (es) * | 2014-08-15 | 2022-12-23 | Merck Patent Gmbh | Proteínas de fusión de inmunoglobulina con SIRP alfa |
WO2016109415A1 (en) | 2014-12-30 | 2016-07-07 | Celgene Corporation | Anti-cd47 antibodies and uses thereof |
CN114716552B (zh) * | 2016-01-11 | 2024-05-24 | 四十七公司 | 人源化、小鼠或嵌合抗cd47单克隆抗体 |
US11427632B2 (en) | 2016-07-06 | 2022-08-30 | Celgene Corporation | Antibodies with low immunogenicity and uses thereof |
EP3586872A4 (en) * | 2017-02-24 | 2020-12-30 | Chugai Seiyaku Kabushiki Kaisha | PHARMACEUTICAL COMPOSITION, ANTIG-BINDING MOLECULES, TREATMENT METHODS AND SCREENING METHODS |
US20200330590A1 (en) | 2017-03-27 | 2020-10-22 | Celgene Corporation | Methods and compositions for reduction of immunogenicity |
US11518810B2 (en) * | 2017-05-08 | 2022-12-06 | Shanghai Jmt-Bio Technology Co., Ltd. | Bispecific recombinant protein and use thereof |
-
2020
- 2020-04-01 TW TW109111389A patent/TW202104260A/zh unknown
- 2020-04-01 TW TW109111390A patent/TW202045550A/zh unknown
- 2020-04-03 WO PCT/US2020/026579 patent/WO2020206255A1/en active Application Filing
- 2020-04-03 EP EP20721358.8A patent/EP3946633A1/en active Pending
- 2020-04-03 WO PCT/US2020/026575 patent/WO2020206251A1/en active Search and Examination
- 2020-04-03 MX MX2021012178A patent/MX2021012178A/es unknown
- 2020-04-03 CN CN202080040804.8A patent/CN114667168A/zh active Pending
- 2020-04-03 AR ARP200100954A patent/AR118595A1/es unknown
- 2020-04-03 US US17/594,134 patent/US20220162330A1/en active Pending
- 2020-04-03 EA EA202192729A patent/EA202192729A1/ru unknown
- 2020-04-03 US US17/594,131 patent/US20220340675A1/en active Pending
- 2020-04-03 PE PE2021001666A patent/PE20212073A1/es unknown
- 2020-04-03 BR BR112021019714A patent/BR112021019714A2/pt unknown
- 2020-04-03 JP JP2021558656A patent/JP2022535324A/ja active Pending
- 2020-04-03 KR KR1020217035862A patent/KR20210148290A/ko unknown
- 2020-04-03 AR ARP200100953A patent/AR118594A1/es unknown
- 2020-04-03 JP JP2021558655A patent/JP2022528869A/ja active Pending
- 2020-04-03 KR KR1020217036137A patent/KR20210148317A/ko unknown
- 2020-04-03 CA CA3134964A patent/CA3134964A1/en active Pending
- 2020-04-03 AU AU2020252402A patent/AU2020252402A1/en active Pending
- 2020-04-03 CN CN202080040829.8A patent/CN114269435A/zh active Pending
- 2020-04-03 EP EP20722114.4A patent/EP3946634A1/en active Pending
- 2020-04-03 SG SG11202110736VA patent/SG11202110736VA/en unknown
-
2021
- 2021-10-01 IL IL286889A patent/IL286889A/en unknown
- 2021-10-05 CL CL2021002608A patent/CL2021002608A1/es unknown
- 2021-10-15 CO CONC2021/0013836A patent/CO2021013836A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
SG11202110736VA (en) | 2021-10-28 |
CL2021002608A1 (es) | 2022-06-10 |
EP3946633A1 (en) | 2022-02-09 |
WO2020206255A1 (en) | 2020-10-08 |
MX2021012178A (es) | 2021-11-04 |
JP2022528869A (ja) | 2022-06-16 |
EA202192729A1 (ru) | 2022-01-13 |
WO2020206251A1 (en) | 2020-10-08 |
IL286889A (en) | 2021-10-31 |
EP3946634A1 (en) | 2022-02-09 |
US20220340675A1 (en) | 2022-10-27 |
AU2020252402A1 (en) | 2021-11-18 |
KR20210148317A (ko) | 2021-12-07 |
CN114667168A (zh) | 2022-06-24 |
CN114269435A (zh) | 2022-04-01 |
KR20210148290A (ko) | 2021-12-07 |
TW202045550A (zh) | 2020-12-16 |
US20220162330A1 (en) | 2022-05-26 |
AR118595A1 (es) | 2021-10-20 |
BR112021019714A2 (pt) | 2021-12-14 |
TW202104260A (zh) | 2021-02-01 |
CA3134964A1 (en) | 2020-10-08 |
CO2021013836A2 (es) | 2022-03-29 |
AR118594A1 (es) | 2021-10-20 |
JP2022535324A (ja) | 2022-08-08 |
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