PE20190221A1 - CARRYMYCIN BIOSYNTHETIC GENES GROUP - Google Patents

CARRYMYCIN BIOSYNTHETIC GENES GROUP

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Publication number
PE20190221A1
PE20190221A1 PE2018001213A PE2018001213A PE20190221A1 PE 20190221 A1 PE20190221 A1 PE 20190221A1 PE 2018001213 A PE2018001213 A PE 2018001213A PE 2018001213 A PE2018001213 A PE 2018001213A PE 20190221 A1 PE20190221 A1 PE 20190221A1
Authority
PE
Peru
Prior art keywords
orf
gene
biosynthetic genes
carrymycin
synthesis
Prior art date
Application number
PE2018001213A
Other languages
Spanish (es)
Inventor
Yiguang Wang
Yang Jang
Xiaofeng Zhao
Weiqing He
Jianlu Dai
Original Assignee
Shenyang Fuyang Pharmaceutical Tech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenyang Fuyang Pharmaceutical Tech Co Ltd filed Critical Shenyang Fuyang Pharmaceutical Tech Co Ltd
Publication of PE20190221A1 publication Critical patent/PE20190221A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01064—Testosterone 17-beta-dehydrogenase (NADP+) (1.1.1.64)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01188—Prostaglandin-F synthase (1.1.1.188)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01008—Acyl-CoA dehydrogenase (NADP+) (1.3.1.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01013—Glycine N-acyltransferase (2.3.1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02007—Glutathione thiolesterase (3.1.2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02003—Dihydroorotase (3.5.2.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente descripcion proporciona una agrupacion de genes biosinteticos de carrimicina. La agrupacion de genes biosinteticos comprende 44 marcos abiertos de lectura de genes (orf), es decir, 5 orfs (orf10-14) que codifican la policetido sintasa, 9 orf (orf1 , 4-6, 15 y 36-39) relacionados con la unidad de extension de la sintesis de policetonas y con la modificacion, 16 orf (orf9, 16-22, 24, 26, 28, 29, 33-35 y 41) relacionados con la sintesis de glicosilos, 6 orf (orf7, 8, 30-32 y 40) relacionados con la transferencia de glicosilo, 2 orf (orf3 y 25) relacionados con la resistencia, 4 orf (orf2, 23, 27 y 42) posiblemente relacionados con la regulacion, un orf de gen marcador de resistencia tsr (orf43) y un orf de gen de 4"-micarosa glucosido isovaleril transferasa (orf44)The present description provides a grouping of carrimycin biosynthetic genes. The biosynthetic gene cluster comprises 44 gene open reading frames (orf), that is, 5 orfs (orf10-14) encoding polyketide synthase, 9 orf (orf1, 4-6, 15 and 36-39) related to the extension unit of the polyketone synthesis and with the modification, 16 orf (orf9, 16-22, 24, 26, 28, 29, 33-35 and 41) related to the synthesis of glycosyl, 6 orf (orf7, 8 , 30-32 and 40) related to glycosyl transfer, 2 orf (orf3 and 25) related to resistance, 4 orf (orf2, 23, 27 and 42) possibly related to regulation, a resistance marker gene orf tsr (orf43) and a 4 "-microse glucoside isovaleryl transferase gene orf (orf44)

PE2018001213A 2015-12-31 2016-11-24 CARRYMYCIN BIOSYNTHETIC GENES GROUP PE20190221A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201511028754.9A CN105505954B (en) 2015-12-31 2015-12-31 Rokitamycin biological synthesis gene cluster
PCT/CN2016/107039 WO2017114034A1 (en) 2015-12-31 2016-11-24 Carrimycin biosynthetic gene cluster

Publications (1)

Publication Number Publication Date
PE20190221A1 true PE20190221A1 (en) 2019-02-13

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ID=55714247

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PE2018001213A PE20190221A1 (en) 2015-12-31 2016-11-24 CARRYMYCIN BIOSYNTHETIC GENES GROUP

Country Status (20)

Country Link
US (1) US10858659B2 (en)
EP (1) EP3385386B3 (en)
JP (1) JP6882330B2 (en)
KR (1) KR20180093083A (en)
CN (2) CN105505954B (en)
AU (1) AU2016383270A1 (en)
BR (1) BR112018013309A2 (en)
CA (1) CA3009706A1 (en)
CL (1) CL2018001796A1 (en)
CO (1) CO2018007130A2 (en)
DK (1) DK3385386T6 (en)
ES (1) ES2812256T7 (en)
MY (1) MY193028A (en)
PE (1) PE20190221A1 (en)
PH (1) PH12018501393A1 (en)
PL (1) PL3385386T6 (en)
RU (1) RU2719189C2 (en)
UA (1) UA124058C2 (en)
WO (1) WO2017114034A1 (en)
ZA (1) ZA201804397B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106916835B (en) * 2015-12-24 2022-08-12 武汉合生科技有限公司 Biosynthetic gene cluster of compounds and application thereof
CN105505954B (en) * 2015-12-31 2019-01-22 沈阳福洋医药科技有限公司 Rokitamycin biological synthesis gene cluster
RU2746047C1 (en) 2017-04-06 2021-04-06 Шенянг Фуянг Фармасьютекал Технолоджи Ко., Лтд. The use of carrimycin and its pharmaceutically acceptable salts for the production of medicines for treatment and / or tumor prevention
CN111349595A (en) * 2018-12-20 2020-06-30 沈阳福洋医药科技有限公司 Spiramycin-producing strain, rokitamycin-producing strain, construction method, application and method for improving product yield
CN111197019B (en) * 2020-01-10 2022-04-15 安徽大学 Method for improving yield of erythromycin through saccharopolyspora erythraea SACE _1906 gene approach
CN114517175B (en) * 2020-11-20 2024-04-09 上海医药工业研究院 Genetically engineered bacterium and application thereof

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CN1058295C (en) * 1997-06-03 2000-11-08 中国医学科学院医药生物技术研究所 Biomycin producing method utilizing gene engineering technology
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CN105505954B (en) 2015-12-31 2019-01-22 沈阳福洋医药科技有限公司 Rokitamycin biological synthesis gene cluster

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Publication number Publication date
CN105505954B (en) 2019-01-22
PL3385386T6 (en) 2021-04-19
JP6882330B2 (en) 2021-06-02
ZA201804397B (en) 2019-09-25
PH12018501393A1 (en) 2019-02-27
US10858659B2 (en) 2020-12-08
RU2018125487A3 (en) 2020-02-14
MY193028A (en) 2022-09-23
PL3385386T3 (en) 2020-11-30
RU2719189C2 (en) 2020-04-17
WO2017114034A1 (en) 2017-07-06
CL2018001796A1 (en) 2018-09-28
EP3385386A4 (en) 2018-10-10
CN105505954A (en) 2016-04-20
ES2812256T3 (en) 2021-03-16
CN107868789A (en) 2018-04-03
CN107868789B (en) 2020-11-17
DK3385386T3 (en) 2020-08-31
KR20180093083A (en) 2018-08-20
EP3385386B1 (en) 2020-05-27
ES2812256T7 (en) 2021-09-22
DK3385386T6 (en) 2021-02-08
AU2016383270A1 (en) 2018-07-26
RU2018125487A (en) 2020-01-31
BR112018013309A2 (en) 2018-12-11
UA124058C2 (en) 2021-07-14
EP3385386B3 (en) 2020-11-18
EP3385386A1 (en) 2018-10-10
JP2019500903A (en) 2019-01-17
US20190093112A1 (en) 2019-03-28
CA3009706A1 (en) 2017-07-06
CO2018007130A2 (en) 2018-07-19

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