PE20141553A1 - Compuestos de triazolopiridina como inhibidores de la ped10a - Google Patents
Compuestos de triazolopiridina como inhibidores de la ped10aInfo
- Publication number
- PE20141553A1 PE20141553A1 PE2014000366A PE2014000366A PE20141553A1 PE 20141553 A1 PE20141553 A1 PE 20141553A1 PE 2014000366 A PE2014000366 A PE 2014000366A PE 2014000366 A PE2014000366 A PE 2014000366A PE 20141553 A1 PE20141553 A1 PE 20141553A1
- Authority
- PE
- Peru
- Prior art keywords
- compounds
- heteroaryl
- alkyl
- aryl
- ped10a
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000008523 triazolopyridines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 ALKYL Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11181752 | 2011-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20141553A1 true PE20141553A1 (es) | 2014-10-30 |
Family
ID=46851999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000366A PE20141553A1 (es) | 2011-09-19 | 2012-09-17 | Compuestos de triazolopiridina como inhibidores de la ped10a |
Country Status (19)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013043518A1 (en) | 2011-09-22 | 2013-03-28 | Merck Sharp & Dohme Corp. | Imidazopyridyl compounds as aldosterone synthase inhibitors |
| US9193724B2 (en) | 2011-09-22 | 2015-11-24 | Merck Sharp & Dohme Corp. | Triazolopyridyl compounds as aldosterone synthase inhibitors |
| AR096118A1 (es) * | 2013-04-30 | 2015-12-09 | Hoffmann La Roche | Condensación de pirazol-amidas catalizadas con pd |
| TWI652014B (zh) | 2013-09-13 | 2019-03-01 | 美商艾佛艾姆希公司 | 雜環取代之雙環唑殺蟲劑 |
| US9879009B2 (en) | 2014-07-30 | 2018-01-30 | Mochida Pharmaceutical Co., Ltd. | Pyrazole derivative manufacturing method |
| CN107074844A (zh) * | 2014-07-30 | 2017-08-18 | 持田制药株式会社 | 吡唑衍生物的制造方法 |
| WO2016144351A1 (en) | 2015-03-11 | 2016-09-15 | E. I. Du Pont De Nemours And Company | Heterocycle-substituted bicyclic azole pesticides |
| EP3268359B1 (en) | 2015-03-12 | 2019-12-18 | FMC Corporation | Heterocycle-substituted bicyclic azole pesticides |
| US10800794B2 (en) | 2015-10-08 | 2020-10-13 | Fmc Corporation | Heterocycle-substituted bicyclic azole pesticides |
| KR102600330B1 (ko) | 2017-08-22 | 2023-11-10 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 헤테로시클렌 유도체 |
| ES2969738T3 (es) | 2019-05-27 | 2024-05-22 | Nihon Nohyaku Co Ltd | Compuesto heterocíclico condensado que tiene un átomo de nitrógeno como cabeza de puente o una sal del mismo, insecticida agrícola u hortícola que comprende el compuesto y método para usar el insecticida |
| AR119140A1 (es) | 2019-06-13 | 2021-11-24 | Pi Industries Ltd | Compuestos heterocíclicos fusionados y su uso como agentes de control de plagas |
| CN110396157B (zh) * | 2019-08-07 | 2021-07-30 | 广州市建筑科学研究院有限公司 | 缓释型聚羧酸纳米减水剂及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355653B1 (en) * | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
| JP2007508241A (ja) | 2003-07-31 | 2007-04-05 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | Ｐｄｅ１０ａ阻害剤を用いる糖尿病および関連障害の処置方法 |
| NL2000397C2 (nl) * | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
| JPWO2010035745A1 (ja) * | 2008-09-25 | 2012-02-23 | 杏林製薬株式会社 | ヘテロ環ビアリール誘導体及びそれらを有効成分とするｐｄｅ阻害剤 |
| WO2010059836A1 (en) * | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Substituted aza-bridged bicyclics for cardiovascular and cns disease |
| WO2010117926A1 (en) * | 2009-04-07 | 2010-10-14 | Schering Corporation | Substituted triazolopyridines and analogs thereof |
| KR101426624B1 (ko) * | 2009-09-24 | 2014-08-05 | 에프. 호프만-라 로슈 아게 | 포스포다이에스터라제 10a 억제제로서 이미다조피리딘 또는 이미다조피리미딘 유도체 |
| CN102696239B (zh) | 2009-11-24 | 2020-08-25 | 诺基亚技术有限公司 | 一种设备 |
| TWI485151B (zh) * | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| TW201200516A (en) * | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
| TWI487705B (zh) * | 2009-12-17 | 2015-06-11 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族芳基三唑衍生物 |
-
2012
- 2012-09-17 EP EP12759445.5A patent/EP2758396B1/en not_active Not-in-force
- 2012-09-17 PH PH1/2014/500499A patent/PH12014500499A1/en unknown
- 2012-09-17 ES ES12759445.5T patent/ES2626801T3/es active Active
- 2012-09-17 KR KR1020147009588A patent/KR101584925B1/ko not_active Expired - Fee Related
- 2012-09-17 PE PE2014000366A patent/PE20141553A1/es not_active Application Discontinuation
- 2012-09-17 UA UAA201404029A patent/UA108711C2/uk unknown
- 2012-09-17 JP JP2014531187A patent/JP2014526533A/ja active Pending
- 2012-09-17 EA EA201490599A patent/EA201490599A1/ru unknown
- 2012-09-17 BR BR112014006248A patent/BR112014006248A2/pt not_active IP Right Cessation
- 2012-09-17 CN CN201280045398.XA patent/CN103827114B/zh not_active Expired - Fee Related
- 2012-09-17 WO PCT/EP2012/068203 patent/WO2013041472A1/en not_active Ceased
- 2012-09-17 MX MX2014003025A patent/MX2014003025A/es active IP Right Grant
- 2012-09-17 AU AU2012311713A patent/AU2012311713A1/en not_active Abandoned
- 2012-09-17 SG SG11201400759RA patent/SG11201400759RA/en unknown
- 2012-09-17 CA CA2846758A patent/CA2846758C/en not_active Expired - Fee Related
-
2014
- 2014-03-05 CO CO14047250A patent/CO6900144A2/es unknown
- 2014-03-06 IL IL231403A patent/IL231403A0/en unknown
- 2014-03-17 CL CL2014000641A patent/CL2014000641A1/es unknown
- 2014-03-18 US US14/218,275 patent/US8946427B2/en not_active Expired - Fee Related
- 2014-12-16 US US14/572,312 patent/US9227970B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| UA108711C2 (uk) | 2015-05-25 |
| EP2758396B1 (en) | 2017-03-29 |
| US20140303141A1 (en) | 2014-10-09 |
| BR112014006248A2 (pt) | 2017-04-11 |
| AU2012311713A1 (en) | 2014-03-13 |
| US20150099735A1 (en) | 2015-04-09 |
| MX2014003025A (es) | 2014-05-28 |
| US9227970B2 (en) | 2016-01-05 |
| CL2014000641A1 (es) | 2014-11-14 |
| NZ621597A (en) | 2015-04-24 |
| JP2014526533A (ja) | 2014-10-06 |
| CN103827114A (zh) | 2014-05-28 |
| WO2013041472A1 (en) | 2013-03-28 |
| EA201490599A1 (ru) | 2014-07-30 |
| IL231403A0 (en) | 2014-04-30 |
| CA2846758A1 (en) | 2013-03-28 |
| ES2626801T3 (es) | 2017-07-26 |
| CN103827114B (zh) | 2016-08-24 |
| PH12014500499A1 (en) | 2014-04-14 |
| SG11201400759RA (en) | 2014-07-30 |
| KR101584925B1 (ko) | 2016-01-12 |
| CA2846758C (en) | 2017-09-12 |
| CO6900144A2 (es) | 2014-03-20 |
| US8946427B2 (en) | 2015-02-03 |
| KR20140075716A (ko) | 2014-06-19 |
| EP2758396A1 (en) | 2014-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |